{"id":"https://openalex.org/W1964552605","doi":"https://doi.org/10.1159/000329120","title":"Inhibitory Effects of Rosiglitazone on Lipopolysaccharide-Induced Inflammation in a Murine Model and HK-2 Cells","display_name":"Inhibitory Effects of Rosiglitazone on Lipopolysaccharide-Induced Inflammation in a Murine Model and HK-2 Cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1964552605","doi":"https://doi.org/10.1159/000329120","mag":"1964552605","pmid":"https://pubmed.ncbi.nlm.nih.gov/21734368"},"language":"en","primary_location":{"id":"doi:10.1159/000329120","doi":"https://doi.org/10.1159/000329120","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000329120","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067869059","display_name":"W.M. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W.M. Wang","raw_affiliation_strings":["Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, PR China","Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080050123","display_name":"H. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Chen","raw_affiliation_strings":["Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026822437","display_name":"Fang Zhong","orcid":"https://orcid.org/0000-0002-3165-6884","observed_orcids":["https://orcid.org/0000-0002-3165-6884"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"F. Zhong","raw_affiliation_strings":["Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047527341","display_name":"Ying Lu","orcid":"https://orcid.org/0000-0002-3545-1026","observed_orcids":["https://orcid.org/0000-0002-3545-1026"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Lu","raw_affiliation_strings":["Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101836793","display_name":"Lu Han","orcid":"https://orcid.org/0000-0002-1753-0732","observed_orcids":["https://orcid.org/0000-0002-1753-0732","https://orcid.org/0000-0002-6119-4895"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Han","raw_affiliation_strings":["Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046658767","display_name":"N. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"N. Chen","raw_affiliation_strings":["Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4712,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.60196895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"2","first_page":"152","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":1.0},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9419999718666077},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gw9662","display_name":"GW9662","score":0.8849999904632568},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.47699999809265137},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.9863694906234741},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7490307092666626},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6848363280296326},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6543418765068054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.641486406326294},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5439900755882263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.53230881690979},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.502990186214447},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4568316638469696},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4333462715148926},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43130743503570557},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34650760889053345}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000329120","doi":"https://doi.org/10.1159/000329120","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000329120","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},{"id":"pmid:21734368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21734368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nephrology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1639924204","https://openalex.org/W1812285428","https://openalex.org/W1951826532","https://openalex.org/W1965772617","https://openalex.org/W1981283273","https://openalex.org/W1990641914","https://openalex.org/W1997608954","https://openalex.org/W2016361851","https://openalex.org/W2018308218","https://openalex.org/W2031032207","https://openalex.org/W2034107476","https://openalex.org/W2034649412","https://openalex.org/W2035838779","https://openalex.org/W2036010496","https://openalex.org/W2046833545","https://openalex.org/W2047852384","https://openalex.org/W2048615690","https://openalex.org/W2061257823","https://openalex.org/W2068245632","https://openalex.org/W2068675523","https://openalex.org/W2074740965","https://openalex.org/W2099925178","https://openalex.org/W2101329987","https://openalex.org/W2102634499","https://openalex.org/W2103353049","https://openalex.org/W2109336702","https://openalex.org/W2119745892","https://openalex.org/W2128573668","https://openalex.org/W2134215445","https://openalex.org/W2134339804","https://openalex.org/W2144829836","https://openalex.org/W2146942873","https://openalex.org/W2148962636","https://openalex.org/W2158362986","https://openalex.org/W2165199383","https://openalex.org/W2165640401","https://openalex.org/W2194254893"],"related_works":["https://openalex.org/W2126085844","https://openalex.org/W2041969270","https://openalex.org/W2014113220","https://openalex.org/W1965765907","https://openalex.org/W1965393911","https://openalex.org/W2889248919","https://openalex.org/W2077738040","https://openalex.org/W2116160593","https://openalex.org/W2068121938","https://openalex.org/W2108672863"],"abstract_inverted_index":{"BACKGROUND:":[0],"Inflammation":[1],"may":[2],"play":[3],"an":[4],"important":[5],"role":[6],"in":[7,106,143,172,181,244],"the":[8,15,32,45,57,80,114,136,147,173,182,224],"pathogenesis":[9],"of":[10,14,34,39,47,59,226,229],"kidney":[11,52,221],"disease.":[12],"Agonists":[13],"peroxisome":[16],"proliferator-activated":[17],"receptor-\u03b3":[18],"(PPAR-\u03b3),":[19],"such":[20],"as":[21,193,195],"rosiglitazone,":[22],"have":[23],"been":[24],"recently":[25],"demonstrated":[26],"to":[27,43,55,135],"regulate":[28],"inflammation":[29,53,222],"by":[30,209],"modulating":[31],"production":[33],"inflammatory":[35],"mediators.":[36],"The":[37],"purpose":[38],"this":[40],"study":[41],"was":[42],"examine":[44],"effects":[46,206],"rosiglitazone":[48,112,142,186,218],"on":[49],"lipopolysaccharide":[50],"(LPS)-induced":[51],"and":[54,93,95,118,128,154,165,190,198,232],"explore":[56],"mechanism":[58],"its":[60],"renoprotection.":[61],"METHODS:":[62],"Mice":[63],"were":[64,98,102,131,169,207],"treated":[65,109],"with":[66,68,72,110,121,141,217],"LPS":[67,137,174],"or":[69],"without":[70],"pretreatment":[71,140,216],"rosiglitazone.":[73],"Blood":[74],"urea":[75],"nitrogen":[76],"(BUN),":[77],"creatinine":[78],"levels,":[79],"urinary":[81],"albumin-to-creatinine":[82],"ratio,":[83],"macrophage":[84,150],"infiltration,":[85,151],"monocyte":[86],"chemoattractant":[87],"protein-1":[88],"(MCP-1)":[89],"expression,":[90,92],"PPAR-\u03b3":[91,96,115,129,163,200],"NF-\u03baB":[94,126,155,196,233],"activity":[97,127,156],"investigated.":[99,132],"HK-2":[100,184,246],"cells":[101],"maintained":[103],"under":[104],"defined":[105],"vitro":[107],"conditions,":[108],"either":[111],"and/or":[113],"antagonist":[116],"GW9662,":[117],"then":[119],"stimulated":[120],"LPS.":[122],"MCP-1,":[123,188],"IL-8,":[124],"IL-6,":[125],"expression":[130,164,192,201],"RESULTS:":[133],"Compared":[134],"only":[138,175],"group,":[139],"vivo":[144],"significantly":[145,171],"attenuated":[146],"BUN":[148],"levels":[149],"MCP-1":[152,230],"overexpression":[153],"(p":[157,177,202],"<":[158,178,203],"0.05).":[159,179,204],"Rosiglitazone":[160,235],"also":[161],"restored":[162],"protein":[166],"activity,":[167],"which":[168],"reduced":[170],"group":[176],"Furthermore,":[180],"LPS-stimulated":[183],"cells,":[185],"downregulated":[187],"IL-8":[189],"IL-6":[191],"well":[194],"activation":[197,225],"increased":[199],"These":[205,212],"diminished":[208],"GW9662.":[210],"CONCLUSION:":[211],"results":[213],"showed":[214],"that":[215],"could":[219],"attenuate":[220],"through":[223],"PPAR-\u03b3,":[227],"suppression":[228],"overproduction":[231],"activation.":[234],"had":[236],"a":[237,241],"protective":[238],"effect":[239],"via":[240],"PPAR-\u03b3-dependent":[242],"pathway":[243],"LPS-treated":[245],"cells.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}