{"id":"https://openalex.org/W1964536962","doi":"https://doi.org/10.1016/j.clim.2008.08.016","title":"The innate immune response in ischemic acute kidney injury","display_name":"The innate immune response in ischemic acute kidney injury","publication_year":2008,"publication_date":"2008-10-15","ids":{"openalex":"https://openalex.org/W1964536962","doi":"https://doi.org/10.1016/j.clim.2008.08.016","mag":"1964536962","pmid":"https://pubmed.ncbi.nlm.nih.gov/18922742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646108"},"language":"en","primary_location":{"id":"doi:10.1016/j.clim.2008.08.016","doi":"https://doi.org/10.1016/j.clim.2008.08.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2008.08.016","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646108","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024213022","display_name":"Hye Ryoun Jang","orcid":"https://orcid.org/0000-0001-9856-6341","observed_orcids":["https://orcid.org/0000-0001-9856-6341"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye Ryoun Jang","raw_affiliation_strings":["Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025048132","display_name":"Hamid Rabb","orcid":"https://orcid.org/0000-0002-4761-1103","observed_orcids":["https://orcid.org/0000-0002-4761-1103"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hamid Rabb","raw_affiliation_strings":["Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Department of Medicine, Johns Hopkins University School of Medicine, Ross Building, Room 965, 720 Rutland Avenue, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025048132"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":2.7109,"has_fulltext":false,"cited_by_count":352,"citation_normalized_percentile":{"value":0.93213573,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"130","issue":"1","first_page":"41","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.7850000262260437},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9980000257492065},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":1.0},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":1.0},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9179999828338623},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.8820000290870667},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8231607675552368},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7671083211898804},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6859098076820374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6685065031051636},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6612923741340637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6298279762268066},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5980006456375122},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5785528421401978},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49714425206184387},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4378223419189453},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4191967248916626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1167711615562439}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.clim.2008.08.016","doi":"https://doi.org/10.1016/j.clim.2008.08.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2008.08.016","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:18922742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18922742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology (Orlando, Fla.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2646108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2646108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646108","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5812112042","display_name":"T cell modulation of renal ischemia reperfusion injury.","funder_award_id":"R01DK054770","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W23360501","https://openalex.org/W1487452928","https://openalex.org/W1502124510","https://openalex.org/W1511030747","https://openalex.org/W1548761095","https://openalex.org/W1575309759","https://openalex.org/W1752304426","https://openalex.org/W1842545013","https://openalex.org/W1932854388","https://openalex.org/W1940749453","https://openalex.org/W1947658782","https://openalex.org/W1965737875","https://openalex.org/W1967313614","https://openalex.org/W1968265929","https://openalex.org/W1968709826","https://openalex.org/W1969126678","https://openalex.org/W1969751051","https://openalex.org/W1973281835","https://openalex.org/W1981033024","https://openalex.org/W1983113400","https://openalex.org/W1984974003","https://openalex.org/W1989478136","https://openalex.org/W1991782173","https://openalex.org/W1994510935","https://openalex.org/W1997867159","https://openalex.org/W1999755139","https://openalex.org/W2001579081","https://openalex.org/W2007929302","https://openalex.org/W2015179134","https://openalex.org/W2015213347","https://openalex.org/W2015746497","https://openalex.org/W2017405235","https://openalex.org/W2019690943","https://openalex.org/W2021114973","https://openalex.org/W2023300193","https://openalex.org/W2023956699","https://openalex.org/W2026959355","https://openalex.org/W2027809685","https://openalex.org/W2027917795","https://openalex.org/W2028628211","https://openalex.org/W2028965877","https://openalex.org/W2034745503","https://openalex.org/W2037034589","https://openalex.org/W2043551147","https://openalex.org/W2045871570","https://openalex.org/W2046149192","https://openalex.org/W2046586570","https://openalex.org/W2051968073","https://openalex.org/W2053793434","https://openalex.org/W2059456964","https://openalex.org/W2060206045","https://openalex.org/W2061907788","https://openalex.org/W2062229313","https://openalex.org/W2066697125","https://openalex.org/W2067709564","https://openalex.org/W2073220544","https://openalex.org/W2075416546","https://openalex.org/W2076189699","https://openalex.org/W2076565680","https://openalex.org/W2077196241","https://openalex.org/W2080393507","https://openalex.org/W2082333641","https://openalex.org/W2086417798","https://openalex.org/W2086723409","https://openalex.org/W2094742966","https://openalex.org/W2095486060","https://openalex.org/W2106507564","https://openalex.org/W2108935165","https://openalex.org/W2109531941","https://openalex.org/W2109995603","https://openalex.org/W2110229188","https://openalex.org/W2110899107","https://openalex.org/W2112309389","https://openalex.org/W2122918206","https://openalex.org/W2123698136","https://openalex.org/W2132580725","https://openalex.org/W2133186273","https://openalex.org/W2134085807","https://openalex.org/W2135218578","https://openalex.org/W2141781896","https://openalex.org/W2143461874","https://openalex.org/W2144000554","https://openalex.org/W2145103027","https://openalex.org/W2149576310","https://openalex.org/W2151181348","https://openalex.org/W2158358030","https://openalex.org/W2160908214","https://openalex.org/W2163986317","https://openalex.org/W2164655249","https://openalex.org/W2165192883","https://openalex.org/W2168194514","https://openalex.org/W2168893141","https://openalex.org/W2170392635","https://openalex.org/W2211459284","https://openalex.org/W2215726651","https://openalex.org/W2415856485","https://openalex.org/W2987693786","https://openalex.org/W4236514815","https://openalex.org/W4299584742","https://openalex.org/W6716592605"],"related_works":["https://openalex.org/W2162724808","https://openalex.org/W1972498265","https://openalex.org/W2944020574","https://openalex.org/W2137639174","https://openalex.org/W2621553746","https://openalex.org/W1986240011","https://openalex.org/W3030961331","https://openalex.org/W2895365495","https://openalex.org/W1518961143","https://openalex.org/W2158674216"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
