{"id":"https://openalex.org/W1964535009","doi":"https://doi.org/10.1371/journal.pone.0063571","title":"Characterization and Pharmacological Properties of a Novel Multifunctional Kunitz Inhibitor from Erythrina velutina Seeds","display_name":"Characterization and Pharmacological Properties of a Novel Multifunctional Kunitz Inhibitor from Erythrina velutina Seeds","publication_year":2013,"publication_date":"2013-05-28","ids":{"openalex":"https://openalex.org/W1964535009","doi":"https://doi.org/10.1371/journal.pone.0063571","mag":"1964535009","pmid":"https://pubmed.ncbi.nlm.nih.gov/23737945","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666885"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0063571","doi":"https://doi.org/10.1371/journal.pone.0063571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0063571","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063571&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063571&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063872688","display_name":"Richele Jana\u00edna de Ara\u00fajo Machado","orcid":"https://orcid.org/0000-0003-2321-4020","observed_orcids":["https://orcid.org/0000-0003-2321-4020","https://orcid.org/0000-0002-1213-7560"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Richele J. A. Machado","raw_affiliation_strings":["Laborat\u00f3rio de Qu\u00edmica e Fun\u00e7\u00e3o de Prote\u00ednas Bioativas, Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica e Fun\u00e7\u00e3o de Prote\u00ednas Bioativas, Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017655268","display_name":"Norberto de K\u00e1ssio Vieira Monteiro","orcid":"https://orcid.org/0000-0002-5847-5733","observed_orcids":["https://orcid.org/0000-0002-5847-5733"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Norberto K. V. Monteiro","raw_affiliation_strings":["Departamento de Nutri\u00e7\u00e3o, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Nutri\u00e7\u00e3o, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085458408","display_name":"Ludovico Migliolo","orcid":"https://orcid.org/0000-0002-6606-2189","observed_orcids":["https://orcid.org/0000-0002-6606-2189","https://orcid.org/0000-0001-9100-3175"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ludovico Migliolo","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051878782","display_name":"Osmar Nascimento Silva","orcid":"https://orcid.org/0000-0003-2148-131X","observed_orcids":["https://orcid.org/0000-0003-2148-131X"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Osmar N. Silva","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005809759","display_name":"Michele F. S. Pinto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Michele F. S. Pinto","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107859216","display_name":"Adeliana S. Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adeliana S. Oliveira","raw_affiliation_strings":["Laborat\u00f3rio de Qu\u00edmica e Fun\u00e7\u00e3o de Prote\u00ednas Bioativas, Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica e Fun\u00e7\u00e3o de Prote\u00ednas Bioativas, Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036861140","display_name":"Oct\u00e1vio Luiz Franco","orcid":"https://orcid.org/0000-0001-9546-0525","observed_orcids":["https://orcid.org/0000-0001-9546-0525"]},"institutions":[{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Oct\u00e1vio L. Franco","raw_affiliation_strings":["Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de An\u00e1lises Prote\u00f4micas e Bioqu\u00edmicas, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias G\u00eanomicas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I24871856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002164754","display_name":"Sumika Kiyota","orcid":"https://orcid.org/0000-0002-0658-3775","observed_orcids":["https://orcid.org/0000-0002-0658-3775"]},"institutions":[{"id":"https://openalex.org/I134493880","display_name":"Instituto Biol\u00f3gico","ror":"https://ror.org/05p4qy423","country_code":"BR","type":"facility","lineage":["https://openalex.org/I134493880"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sumika Kiyota","raw_affiliation_strings":["Laborat\u00f3rio de Bioqu\u00edmica de Prote\u00ednas e Pept\u00eddeos, Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biol\u00f3gico, S\u00e3o Paulo, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Bioqu\u00edmica de Prote\u00ednas e Pept\u00eddeos, Centro de Pesquisa e Desenvolvimento de Sanidade Animal, Instituto Biol\u00f3gico, S\u00e3o Paulo, Brasil","institution_ids":["https://openalex.org/I134493880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007484652","display_name":"Marcelo P. Bemquerer","orcid":"https://orcid.org/0000-0002-9740-5818","observed_orcids":["https://orcid.org/0000-0002-9740-5818"]},"institutions":[{"id":"https://openalex.org/I4405284811","display_name":"Embrapa Recursos Gen\u00e9ticos e Biotecnologia","ror":"https://ror.org/047y8rp84","country_code":"BR","type":"government","lineage":["https://openalex.org/I199691007","https://openalex.org/I4405284811"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo P. Bemquerer","raw_affiliation_strings":["Laborat\u00f3rio de Espectrometria de Massa, Embrapa Recursos Gen\u00e9ticos e Biotecnologia, Bras\u00edlia, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Espectrometria de Massa, Embrapa Recursos Gen\u00e9ticos e Biotecnologia, Bras\u00edlia, Brasil","institution_ids":["https://openalex.org/I4405284811"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013389654","display_name":"Adriana Ferreira Uch\u00f4a","orcid":"https://orcid.org/0000-0002-3822-6502","observed_orcids":["https://orcid.org/0000-0002-3822-6502"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana F. Uchoa","raw_affiliation_strings":["Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biologia Celular e Gen\u00e9tica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007277259","display_name":"Ana Heloneida de Ara\u00fajo Morais","orcid":"https://orcid.org/0000-0002-6460-911X","observed_orcids":["https://orcid.org/0000-0002-6460-911X"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana H. A. Morais","raw_affiliation_strings":["Departamento de Nutri\u00e7\u00e3o, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Nutri\u00e7\u00e3o, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078237945","display_name":"Elizeu Antunes dos Santos","orcid":"https://orcid.org/0000-0003-4372-2161","observed_orcids":["https://orcid.org/0000-0003-4372-2161"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elizeu A. Santos","raw_affiliation_strings":["Laborat\u00f3rio de Qu\u00edmica e Fun\u00e7\u00e3o de Prote\u00ednas Bioativas, Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica e Fun\u00e7\u00e3o de Prote\u00ednas Bioativas, Departamento de Bioqu\u00edmica, Centro de Bioci\u00eancias, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil","institution_ids":["https://openalex.org/I35046152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036861140"],"corresponding_institution_ids":["https://openalex.org/I24871856"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1251,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.74906213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"e63571","last_page":"e63571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kunitz-trypsin-inhibitor","display_name":"Kunitz trypsin inhibitor","score":0.968999981880188},{"id":"https://openalex.org/keywords/erythrina-velutina","display_name":"Erythrina velutina","score":0.9559999704360962},{"id":"https://openalex.org/keywords/leguminous-seeds","display_name":"leguminous seeds","score":0.8560000061988831},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/inhibitor-purification","display_name":"inhibitor purification","score":0.5759999752044678},{"id":"https://openalex.org/keywords/primary-structure","display_name":"primary structure","score":0.5009999871253967},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.8560000061988831},{"id":"https://openalex.org/keywords/factor-xa-inhibition","display_name":"factor Xa inhibition","score":0.871999979019165},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/anticoagulant-activity","display_name":"anticoagulant activity","score":0.968999981880188},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9100000262260437},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.968999981880188},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.7557461261749268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6493052244186401},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5725806355476379},{"id":"https://openalex.org/C2778401398","wikidata":"https://www.wikidata.org/wiki/Q383836","display_name":"Chymotrypsin","level":4,"score":0.5106895565986633},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.45094963908195496},{"id":"https://openalex.org/C2776351012","wikidata":"https://www.wikidata.org/wiki/Q7848794","display_name":"Trypsin inhibitor","level":4,"score":0.43590739369392395},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26478442549705505}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004895","descriptor_name":"Erythrina","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014361","descriptor_name":"Trypsin Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014361","descriptor_name":"Trypsin Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014361","descriptor_name":"Trypsin Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0063571","doi":"https://doi.org/10.1371/journal.pone.0063571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0063571","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063571&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2670321","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3666885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23737945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23737945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3666885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3666885/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:repositorio.ufrn.br:123456789/58137","doi":null,"is_oa":true,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063571.","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:www.alice.cnptia.embrapa.br:doc/980468","doi":null,"is_oa":true,"landing_page_url":"http://www.alice.cnptia.embrapa.br/alice/handle/doc/980468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:EMBRAPA","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:2110136","doi":null,"is_oa":true,"landing_page_url":"http://www.alice.cnptia.embrapa.br/alice/handle/doc/980468","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da EMBRAPA","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:3d6afa934fdb40c7957a3ab751b00452","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d6afa934fdb40c7957a3ab751b00452","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 5, p e63571 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/707538","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Characterization_and_Pharmacological_Properties_of_a_Novel_Multifunctional_Kunitz_Inhibitor_from_Erythrina_velutina_Seeds/707538","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0063571","doi":"https://doi.org/10.1371/journal.pone.0063571","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0063571","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063571&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323350","display_name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","ror":"https://ror.org/04djvx395"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964535009.pdf","grobid_xml":"https://content.openalex.org/works/W1964535009.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W69656279","https://openalex.org/W109515511","https://openalex.org/W183273430","https://openalex.org/W1198401078","https://openalex.org/W1485616585","https://openalex.org/W1500259476","https://openalex.org/W1545039766","https://openalex.org/W1553729882","https://openalex.org/W1606631580","https://openalex.org/W1939586679","https://openalex.org/W1941984374","https://openalex.org/W1964742940","https://openalex.org/W1964772974","https://openalex.org/W1965545332","https://openalex.org/W1968909431","https://openalex.org/W1970214497","https://openalex.org/W1979838917","https://openalex.org/W1986165905","https://openalex.org/W1986461318","https://openalex.org/W1990802251","https://openalex.org/W1997235075","https://openalex.org/W1999593853","https://openalex.org/W1999631604","https://openalex.org/W2000294310","https://openalex.org/W2000593246","https://openalex.org/W2004044422","https://openalex.org/W2004466038","https://openalex.org/W2005250977","https://openalex.org/W2008491437","https://openalex.org/W2009975233","https://openalex.org/W2010290832","https://openalex.org/W2015875563","https://openalex.org/W2018289835","https://openalex.org/W2022413893","https://openalex.org/W2023979264","https://openalex.org/W2028612430","https://openalex.org/W2029619625","https://openalex.org/W2035163939","https://openalex.org/W2037405497","https://openalex.org/W2038546354","https://openalex.org/W2038711669","https://openalex.org/W2040029103","https://openalex.org/W2046740769","https://openalex.org/W2046809087","https://openalex.org/W2048877036","https://openalex.org/W2049276855","https://openalex.org/W2049321670","https://openalex.org/W2052949037","https://openalex.org/W2054022176","https://openalex.org/W2066512868","https://openalex.org/W2072232259","https://openalex.org/W2078594804","https://openalex.org/W2081867057","https://openalex.org/W2083968990","https://openalex.org/W2085711698","https://openalex.org/W2087740401","https://openalex.org/W2090999898","https://openalex.org/W2092229008","https://openalex.org/W2100837269","https://openalex.org/W2101454811","https://openalex.org/W2103196178","https://openalex.org/W2106882534","https://openalex.org/W2112198510","https://openalex.org/W2122934196","https://openalex.org/W2128635872","https://openalex.org/W2132206417","https://openalex.org/W2133937719","https://openalex.org/W2135385800","https://openalex.org/W2141693585","https://openalex.org/W2146425047","https://openalex.org/W2155737125","https://openalex.org/W2156465746","https://openalex.org/W2157282632","https://openalex.org/W2158714788","https://openalex.org/W2167424604","https://openalex.org/W2170427573","https://openalex.org/W2188487519","https://openalex.org/W2314501441","https://openalex.org/W2399485886","https://openalex.org/W2419166597","https://openalex.org/W2890792574","https://openalex.org/W4212788522"],"related_works":["https://openalex.org/W1968909431","https://openalex.org/W2022637110","https://openalex.org/W2312151449","https://openalex.org/W4386592863","https://openalex.org/W2021170239","https://openalex.org/W2883874612","https://openalex.org/W2005250977","https://openalex.org/W3101077837","https://openalex.org/W2902523758","https://openalex.org/W2416375552"],"abstract_inverted_index":{"Inhibitors":[0],"of":[1,27,64,129,136,149,249,252,262],"peptidases":[2],"isolated":[3],"from":[4,33],"leguminous":[5],"seeds":[6,36],"have":[7],"been":[8],"studied":[9],"for":[10,95,171],"their":[11],"pharmacological":[12],"properties.":[13,176],"The":[14,58,77,98,240],"present":[15],"study":[16],"focused":[17],"on":[18,183],"purification,":[19],"biochemical":[20],"characterization":[21],"and":[22,24,52,84,92,105,132,156,174,206,213,227,234,237,267],"anti-inflammatory":[23,173,212],"anticoagulant":[25,214],"evaluation":[26],"a":[28,68,116,140,199,246,258],"novel":[29],"Kunitz":[30,253],"trypsin":[31,82,104,126],"inhibitor":[32,60,78,190],"Erythrina":[34],"velutina":[35],"(EvTI).":[37],"Trypsin":[38],"inhibitors":[39,254],"were":[40,108,220],"purified":[41,59],"by":[42,48,103,111,139,202,230],"ammonium":[43],"sulfate":[44],"(30-60%),":[45],"fractionation":[46],"followed":[47],"Trypsin-Sepharose":[49],"affinity":[50],"chromatography":[51],"reversed-phase":[53],"high":[54],"performance":[55],"liquid":[56],"chromatography.":[57],"showed":[61,80,179],"molecular":[62],"mass":[63,113],"19,210.48":[65],"Da.":[66],"Furthermore,":[67],"second":[69],"isoform":[70],"with":[71,127],"19,228.16":[72],"Da":[73],"was":[74,88,93,169,191],"also":[75,152],"observed.":[76],"that":[79],"highest":[81],"specificity":[83],"enhanced":[85],"recovery":[86],"yield":[87],"named":[89],"EvTI":[90,99,121,151,168,178,215,223],"(P2)":[91],"selected":[94],"further":[96,109],"analysis.":[97],"peptide":[100],"fragments,":[101],"generated":[102],"pepsin":[106],"digestion,":[107],"analyzed":[110],"MALDI-ToF-ToF":[112],"spectrometry,":[114],"allowing":[115],"partial":[117],"primary":[118],"structure":[119],"elucidation.":[120],"exhibited":[122],"inhibitory":[123],"activity":[124,148],"against":[125],"IC50":[128],"2.2\u00d710(-8)":[130],"mol.L(-1)":[131],"constant":[133],"inhibition":[134],"(Ki)":[135],"1.0\u00d710(-8)":[137],"mol.L(-1),":[138],"non-competitive":[141],"mechanism.":[142],"In":[143],"addition":[144],"to":[145,193,211,245],"inhibit":[146,162],"the":[147,189,195,250],"trypsin,":[150],"inhibited":[153,224],"factor":[154],"Xa":[155],"neutrophil":[157],"elastase,":[158],"but":[159],"do":[160],"not":[161],"thrombin,":[163],"chymotrypsin":[164],"or":[165],"peptidase":[166],"3.":[167],"investigated":[170],"its":[172],"anti-coagulant":[175],"Firstly,":[177],"no":[180],"cytotoxic":[181],"effect":[182],"human":[184],"peripheral":[185],"blood":[186,265],"cells.":[187],"Nevertheless,":[188],"able":[192],"prolong":[194],"clotting":[196],"time":[197],"in":[198,204,207,255,264],"dose-dependent":[200],"manner":[201],"using":[203],"vitro":[205],"vivo":[208],"models.":[209],"Due":[210],"properties,":[216],"two":[217],"sepsis":[218,256],"models":[219],"here":[221],"challenged.":[222],"leukocyte":[225],"migration":[226],"specifically":[228],"acted":[229],"inhibiting":[231],"TNF-\u03b1":[232],"release":[233],"stimulating":[235],"IFN-\u03b1":[236],"IL-12":[238],"synthesis.":[239],"data":[241],"presented":[242],"clearly":[243],"contribute":[244],"better":[247],"understanding":[248],"use":[251],"as":[257],"bioactive":[259],"agent":[260],"capable":[261],"interfering":[263],"coagulation":[266],"inflammation.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
