{"id":"https://openalex.org/W1964507233","doi":"https://doi.org/10.1186/1471-2199-9-46","title":"Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue","display_name":"Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1964507233","doi":"https://doi.org/10.1186/1471-2199-9-46","mag":"1964507233","pmid":"https://pubmed.ncbi.nlm.nih.gov/18460208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2396658"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2199-9-46","doi":"https://doi.org/10.1186/1471-2199-9-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2199-9-46","pdf_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-9-46","source":{"id":"https://openalex.org/S73477903","display_name":"BMC Molecular Biology","issn_l":"1471-2199","issn":["1471-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-9-46","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015850991","display_name":"D.T.R. Coulson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David TR Coulson","raw_affiliation_strings":["Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK. d.coulson@qub.ac.uk","Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK. d.coulson@qub.ac.uk","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033335372","display_name":"Simon Brockbank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Simon Brockbank","raw_affiliation_strings":["Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048053821","display_name":"Joseph G. Quinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Joseph G Quinn","raw_affiliation_strings":["Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suzanne Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Suzanne Murphy","raw_affiliation_strings":["Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111403478","display_name":"Rivka Ravid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268717","display_name":"Netherlands Brain Bank","ror":"https://ror.org/01vkgxq49","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4405268717"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rivka Ravid","raw_affiliation_strings":["Netherlands Brain Bank, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Brain Bank, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405268717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110308192","display_name":"G. Brent Irvine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"G Brent Irvine","raw_affiliation_strings":["Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105780181","display_name":"Janet A. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Janet A Johnston","raw_affiliation_strings":["Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, BT9 7BL, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK","institution_ids":["https://openalex.org/I126231945"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015850991","https://openalex.org/A5033335372","https://openalex.org/A5048053821","https://openalex.org/A5105780181","https://openalex.org/A5110308192","https://openalex.org/A5111403478"],"corresponding_institution_ids":["https://openalex.org/I126231945","https://openalex.org/I4405268717"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.8976,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.95110145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"46","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reference-genes","display_name":"reference genes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/rt-qpcr-normalization","display_name":"qRT-PCR normalization","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-expression-stability","display_name":"gene expression stability","score":0.8059999942779541},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.902999997138977},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":1.0},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9120000004768372},{"id":"https://openalex.org/keywords/medial-temporal-gyrus","display_name":"medial temporal gyrus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genorm","display_name":"geNorm","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.6660000085830688},{"id":"https://openalex.org/keywords/14-3-3","display_name":"14-3-3\u03b6","score":0.6779999732971191},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.5960000157356262},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2779148672","wikidata":"https://www.wikidata.org/wiki/Q25326537","display_name":"Reference genes","level":4,"score":0.9036338925361633},{"id":"https://openalex.org/C2779620337","wikidata":"https://www.wikidata.org/wiki/Q14907256","display_name":"SDHA","level":4,"score":0.8018549084663391},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7726459503173828},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6467805504798889},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5860893726348877},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5138938426971436},{"id":"https://openalex.org/C134792803","wikidata":"https://www.wikidata.org/wiki/Q424886","display_name":"Glyceraldehyde 3-phosphate dehydrogenase","level":4,"score":0.4764150381088257},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4357852339744568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3993597626686096},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3932662606239319}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1186/1471-2199-9-46","doi":"https://doi.org/10.1186/1471-2199-9-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2199-9-46","pdf_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-9-46","source":{"id":"https://openalex.org/S73477903","display_name":"BMC Molecular Biology","issn_l":"1471-2199","issn":["1471-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Molecular Biology","raw_type":"journal-article"},{"id":"pmid:18460208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18460208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2396658","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2396658/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Mol Biol","raw_type":"Text"},{"id":"pmh:oai:pure.knaw.nl:openaire_cris_publications/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400439","display_name":"KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Coulson, D T R, Brockbank, S, Quinn, J G, Murphy, S, Ravid, R, Irvine, G B & Johnston, J A 2008, 'Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue.', BMC Molecular Biology, vol. 9, pp. 46. https://doi.org/10.1186/1471-2199-9-46","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.215.2141","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.215.2141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1471-2199-9-46.pdf","raw_type":"text"},{"id":"pmh:knaw:oai:pure.knaw.nl:publications/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Molecular Biology, 9. BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3fea885b58044bb38c8818c68b3cb54d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3fea885b58044bb38c8818c68b3cb54d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Molecular Biology, Vol 9, Iss 1, p 46 (2008)","raw_type":"article"},{"id":"pmh:oai:pure.knaw.nl:publications/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11755/4fa3d609-bdfb-438b-a86f-5cc6f18cd81c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401286","display_name":"KNAW research portal (Royal Academy of Art and Sciences (KNAW))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Coulson, D T R, Brockbank, S, Quinn, J G, Murphy, S, Ravid, R, Irvine, G B & Johnston, J A 2008, 'Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue.', BMC Molecular Biology, vol. 9, pp. 46. https://doi.org/10.1186/1471-2199-9-46","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/2bf28868-2149-4cea-8e58-650552b9f4ea","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/2bf28868-2149-4cea-8e58-650552b9f4ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Coulson, D, Brockbank, S, Quinn, J, Murphy, S, Ravid, R, Irvine, G & Johnston, J 2008, 'Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue.', BMC Molecular Biology, vol. 9, 46, pp. 46. https://doi.org/10.1186/1471-2199-9-46","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2199-9-46","doi":"https://doi.org/10.1186/1471-2199-9-46","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2199-9-46","pdf_url":"https://bmcmolbiol.biomedcentral.com/counter/pdf/10.1186/1471-2199-9-46","source":{"id":"https://openalex.org/S73477903","display_name":"BMC Molecular Biology","issn_l":"1471-2199","issn":["1471-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964507233.pdf","grobid_xml":"https://content.openalex.org/works/W1964507233.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W946191294","https://openalex.org/W1559908984","https://openalex.org/W1577577364","https://openalex.org/W1696199194","https://openalex.org/W1771725737","https://openalex.org/W1958919568","https://openalex.org/W1979456591","https://openalex.org/W1983241347","https://openalex.org/W1986080495","https://openalex.org/W1994761764","https://openalex.org/W2001526641","https://openalex.org/W2019825825","https://openalex.org/W2033219421","https://openalex.org/W2039478554","https://openalex.org/W2057464020","https://openalex.org/W2059875787","https://openalex.org/W2061348306","https://openalex.org/W2087123651","https://openalex.org/W2097266643","https://openalex.org/W2099824652","https://openalex.org/W2105423509","https://openalex.org/W2107277218","https://openalex.org/W2112982595","https://openalex.org/W2123621585","https://openalex.org/W2126835198","https://openalex.org/W2127535576","https://openalex.org/W2131987407","https://openalex.org/W2143146123","https://openalex.org/W2154273881","https://openalex.org/W2154598572","https://openalex.org/W2160619422","https://openalex.org/W2164578725"],"related_works":["https://openalex.org/W2082658803","https://openalex.org/W7095489419","https://openalex.org/W2551568843","https://openalex.org/W7097102565","https://openalex.org/W7221947364","https://openalex.org/W2023475518","https://openalex.org/W2017101849","https://openalex.org/W3154748009","https://openalex.org/W7127590507","https://openalex.org/W2154127252"],"abstract_inverted_index":{"BACKGROUND:":[0],"Studies":[1],"of":[2,14,17,47,72,114,155,189,199,222,231,242],"gene":[3,43,237],"expression":[4,71,112,176,238],"in":[5,80,94,149,187,192,206,239],"post":[6,95],"mortem":[7,96],"human":[8],"brain":[9,97,240],"can":[10],"contribute":[11],"to":[12,41,64,86,182],"understanding":[13],"the":[15,111,184,229],"pathophysiology":[16],"neurodegenerative":[18],"diseases,":[19],"including":[20],"Alzheimer's":[21],"disease":[22,25,194,208],"(AD),":[23],"Parkinson's":[24],"(PD)":[26],"and":[27,143,151,246],"dementia":[28],"with":[29,101,164],"Lewy":[30],"bodies":[31],"(DLB).":[32],"Quantitative":[33],"real-time":[34],"PCR":[35],"(RT":[36],"qPCR)":[37],"is":[38,53,78],"often":[39],"used":[40,63,75],"analyse":[42],"expression.":[44],"The":[45,107,196],"validity":[46],"results":[48],"obtained":[49],"using":[50,168,180],"RT":[51,66,169,232],"qPCR":[52,67,170,233],"reliant":[54],"on":[55],"accurate":[56,203],"data":[57,204,234],"normalization.":[58],"Reference":[59],"genes":[60,77,90,186,200],"are":[61],"generally":[62],"normalize":[65],"data.":[68],"Given":[69],"that":[70],"some":[73],"commonly":[74],"reference":[76,89,117],"altered":[79],"certain":[81],"conditions,":[82],"this":[83],"study":[84,109,218],"aimed":[85],"establish":[87],"which":[88,224],"were":[91],"stably":[92],"expressed":[93],"tissue":[98,241],"from":[99],"individuals":[100],"AD,":[102,157,243],"PD":[103],"or":[104],"DLB.":[105],"RESULTS:":[106],"present":[108],"investigated":[110],"stability":[113,177,191],"8":[115],"candidate":[116,185],"genes,":[118],"(ubiquitin":[119],"C":[120],"[UBC],":[121],"tyrosine-3-monooxygenase":[122],"[YWHAZ],":[123],"RNA":[124],"polymerase":[125],"II":[126],"polypeptide":[127],"[RP":[128],"II],":[129],"hydroxymethylbilane":[130],"synthase":[131],"[HMBS],":[132],"TATA":[133],"box":[134],"binding":[135],"protein":[136],"[TBP],":[137],"beta-2-microglobulin":[138],"[B2M],":[139],"glyceraldehyde-3-phosphate":[140],"dehydrogenase":[141,145],"[GAPDH],":[142],"succinate":[144],"complex-subunit":[146],"A,":[147],"[SDHA])":[148],"cerebellum":[150],"medial":[152],"temporal":[153],"gyrus":[154],"6":[156,158,160],"PD,":[159,244],"DLB":[161,245],"subjects,":[162],"along":[163],"5":[165],"matched":[166],"controls":[167],"(TaqMan(R)":[171],"Gene":[172,175],"Expression":[173],"Assays).":[174],"was":[178,210],"analysed":[179],"geNorm":[181],"rank":[183],"order":[188],"decreasing":[190],"each":[193,207],"group.":[195],"optimal":[197],"number":[198],"recommended":[201],"for":[202,228],"normalization":[205,230],"state":[209],"determined":[211],"by":[212],"pairwise":[213],"variation":[214],"analysis.":[215],"CONCLUSION:":[216],"This":[217],"identified":[219],"validated":[220],"sets":[221],"mRNAs":[223],"would":[225],"be":[226],"appropriate":[227],"when":[235],"studying":[236],"control":[247],"subjects.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}