{"id":"https://openalex.org/W1964493098","doi":"https://doi.org/10.1046/j.1524-4741.1999.98103.x","title":"Tubular Carcinoma of the Breast: Immunohistochemical and DNA Flow Cytometric Profile","display_name":"Tubular Carcinoma of the Breast: Immunohistochemical and DNA Flow Cytometric Profile","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W1964493098","doi":"https://doi.org/10.1046/j.1524-4741.1999.98103.x","mag":"1964493098","pmid":"https://pubmed.ncbi.nlm.nih.gov/11348296"},"language":"en","primary_location":{"id":"doi:10.1046/j.1524-4741.1999.98103.x","doi":"https://doi.org/10.1046/j.1524-4741.1999.98103.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1524-4741.1999.98103.x","pdf_url":null,"source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Maria Fasano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Fasano","raw_affiliation_strings":["Departments of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111675666","display_name":"Eleftherios C. Vamvakas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleftherios Vamvakas","raw_affiliation_strings":["Departments of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070339286","display_name":"Yara Delgado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yara Delgado","raw_affiliation_strings":["Departments of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006640724","display_name":"Giorgio Inghirami","orcid":"https://orcid.org/0000-0001-5566-0864","observed_orcids":["https://orcid.org/0000-0001-5566-0864","https://orcid.org/0000-0002-5298-6516"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giorgio Inghirami","raw_affiliation_strings":["Departments of Pathology,","Kaplan Comprehensive Cancer Center,\u2028New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology,","institution_ids":[]},{"raw_affiliation_string":"Kaplan Comprehensive Cancer Center,\u2028New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110094265","display_name":"Julie S. Mitnick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Mitnick","raw_affiliation_strings":["Radiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089426711","display_name":"Daniel F. Roses","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Roses","raw_affiliation_strings":["Kaplan Comprehensive Cancer Center,\u2028New York University Medical Center, New York, New York","Surgery, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaplan Comprehensive Cancer Center,\u2028New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Surgery, and the","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111948169","display_name":"Helen D. Feiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Helen Feiner","raw_affiliation_strings":["Departments of Pathology,","Kaplan Comprehensive Cancer Center,\u2028New York University Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology,","institution_ids":[]},{"raw_affiliation_string":"Kaplan Comprehensive Cancer Center,\u2028New York University Medical Center, New York, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111948169"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":null,"fwci":0.3777,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54066812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"4","first_page":"252","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.1965000033378601,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubular-carcinoma","display_name":"tubular carcinoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/s-phase-fraction","display_name":"S-phase fraction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/mib-1","display_name":"MIB-1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9649999737739563},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7030537128448486},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6994912028312683},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.6075662970542908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5771108865737915},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5420539975166321},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.509558916091919},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.48994866013526917},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.4829544425010681},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.43000197410583496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4001927375793457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39080092310905457},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3474622964859009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33444106578826904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07914844155311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1524-4741.1999.98103.x","doi":"https://doi.org/10.1046/j.1524-4741.1999.98103.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1524-4741.1999.98103.x","pdf_url":null,"source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},{"id":"pmid:11348296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11348296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The breast journal","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/121771","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/121771","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W42647492","https://openalex.org/W1493891029","https://openalex.org/W1981648386","https://openalex.org/W2010871781","https://openalex.org/W2037539424","https://openalex.org/W2065036744","https://openalex.org/W2071126964","https://openalex.org/W2071525349","https://openalex.org/W2076147080","https://openalex.org/W2079655977","https://openalex.org/W2091945437","https://openalex.org/W2111703821","https://openalex.org/W2162975775","https://openalex.org/W2401916340","https://openalex.org/W2413187173","https://openalex.org/W2432475235"],"related_works":["https://openalex.org/W2004383886","https://openalex.org/W4407082798","https://openalex.org/W2010775670","https://openalex.org/W4388139160","https://openalex.org/W2100003382","https://openalex.org/W4200117958","https://openalex.org/W2415134309","https://openalex.org/W2323862740","https://openalex.org/W1980312171","https://openalex.org/W2056261186"],"abstract_inverted_index":{"Molecular":[0],"markers":[1,64],"of":[2,7,24,52,65,100],"ordinary":[3],"invasive":[4],"ductal":[5],"carcinoma":[6],"the":[8,62],"breast":[9,25],"have":[10,45],"been":[11,19],"extensively":[12],"studied":[13],"and":[14,74,81,85,89,94,132],"their":[15,152],"prognostic":[16],"significance":[17],"has":[18,29],"assessed.":[20],"A":[21],"common":[22],"variant":[23],"cancer,":[26],"tubular":[27,43,53,68,101,140],"carcinoma,":[28],"an":[30,108],"excellent":[31],"prognosis":[32],"as":[33],"judged":[34],"from":[35],"several":[36],"clinicopathologic":[37],"studies.":[38],"One":[39],"would":[40],"assume":[41],"that":[42],"carcinomas":[44,54,69,102,141],"\"favorable\"":[46],"molecular":[47,58,63,144],"markers,":[48],"however,":[49],"published":[50],"series":[51],"do":[55],"not":[56,135],"include":[57],"markers.":[59],"We":[60],"describe":[61],"39":[66],"consecutive":[67],"collected":[70],"between":[71],"January":[72],"1995":[73],"July":[75],"1997.":[76],"DNA":[77,104],"ploidy,":[78],"S-phase,":[79],"estrogen":[80],"progesterone":[82],"receptor":[83],"(ER":[84],"PR,":[86],"respectively)":[87],"expression,":[88],"immunoreactivity":[90],"for":[91],"MIB-1,":[92],"p53,":[93],"erbB2":[95,137],"were":[96,103,114,118,129],"evaluated.":[97],"Seventy-two":[98],"percent":[99],"diploid,":[105],"49%":[106],"had":[107,122],"S-phase":[109],"less":[110,123],"than":[111,124],"5%,":[112],"95%":[113],"ER":[115],"positive,":[116,120],"69%":[117],"PR":[119],"88%":[121],"10%":[125],"MIB-1-positive":[126],"cells,":[127],"97%":[128,133],"p53":[130],"negative,":[131],"did":[134],"overexpress":[136],"protein.":[138],"Thus":[139],"exhibit":[142],"favorable":[143],"characteristics,":[145],"which":[146],"may":[147],"play":[148],"a":[149],"role":[150],"in":[151],"good":[153],"prognosis.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
