{"id":"https://openalex.org/W1964450992","doi":"https://doi.org/10.1016/0920-9964(89)90034-0","title":"The efficacy of the D2 and 5-HT2 antagonist risperidone (R 64 766) in the treatment of chronic psychosis","display_name":"The efficacy of the D2 and 5-HT2 antagonist risperidone (R 64 766) in the treatment of chronic psychosis","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W1964450992","doi":"https://doi.org/10.1016/0920-9964(89)90034-0","mag":"1964450992","pmid":"https://pubmed.ncbi.nlm.nih.gov/2484825"},"language":"en","primary_location":{"id":"doi:10.1016/0920-9964(89)90034-0","doi":"https://doi.org/10.1016/0920-9964(89)90034-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0920-9964(89)90034-0","pdf_url":null,"source":{"id":"https://openalex.org/S144105592","display_name":"Schizophrenia Research","issn_l":"0920-9964","issn":["0920-9964","1573-2509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071466711","display_name":"Jos\u00e9Francisco Castel\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9Francisco Castel\u00e3o","raw_affiliation_strings":["Casa de Sa\u00fcde do Telhal, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Casa de Sa\u00fcde do Telhal, Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111402383","display_name":"Lu\u00eds Ferreira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis Ferreira","raw_affiliation_strings":["Casa de Sa\u00fcde do Telhal, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Casa de Sa\u00fcde do Telhal, Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016248472","display_name":"Yves G. Gelders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096407","display_name":"Hospital de Magalh\u00e3es Lemos","ror":"https://ror.org/00teeat87","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210096407"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Yves G. Gelders","raw_affiliation_strings":["Hospital Magalh\u00e3es Lemos, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Magalh\u00e3es Lemos, Porto, Portugal","institution_ids":["https://openalex.org/I4210096407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109072975","display_name":"S. Heylen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stef L.E. Heylen","raw_affiliation_strings":["Department of Clinical Research and Development, Janssen Research Foundation, B-2340 Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research and Development, Janssen Research Foundation, B-2340 Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016248472"],"corresponding_institution_ids":["https://openalex.org/I4210096407"],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":4.2271,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.94165796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"4-5","first_page":"411","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.9085222482681274},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7638219594955444},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.608554482460022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5187826156616211},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.4736313223838806},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4167037010192871},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32971811294555664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3077118396759033},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.2950071394443512},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05399513244628906}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0920-9964(89)90034-0","doi":"https://doi.org/10.1016/0920-9964(89)90034-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0920-9964(89)90034-0","pdf_url":null,"source":{"id":"https://openalex.org/S144105592","display_name":"Schizophrenia Research","issn_l":"0920-9964","issn":["0920-9964","1573-2509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia Research","raw_type":"journal-article"},{"id":"pmid:2484825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2484825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schizophrenia research","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W61661494","https://openalex.org/W1809659791","https://openalex.org/W1833805811","https://openalex.org/W1954888178","https://openalex.org/W1966155579","https://openalex.org/W1974668241","https://openalex.org/W1997636185","https://openalex.org/W2020669188","https://openalex.org/W2020844317","https://openalex.org/W2032162247","https://openalex.org/W2038742808","https://openalex.org/W2043356853","https://openalex.org/W2061560549","https://openalex.org/W2062646524","https://openalex.org/W2065410209","https://openalex.org/W2065432160","https://openalex.org/W2065758955","https://openalex.org/W2071991156","https://openalex.org/W2083191848","https://openalex.org/W2086063725","https://openalex.org/W2091190659","https://openalex.org/W2092047534","https://openalex.org/W2162836351","https://openalex.org/W2165379748","https://openalex.org/W2174686149","https://openalex.org/W2339803239","https://openalex.org/W2421317886","https://openalex.org/W2462547594","https://openalex.org/W6638236662","https://openalex.org/W6703674147"],"related_works":["https://openalex.org/W2094367989","https://openalex.org/W2412644250","https://openalex.org/W2045765028","https://openalex.org/W1974864624","https://openalex.org/W2044278535","https://openalex.org/W2030880979","https://openalex.org/W2092618357","https://openalex.org/W2144513312","https://openalex.org/W2159165479","https://openalex.org/W2146438680"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}