{"id":"https://openalex.org/W1964445501","doi":"https://doi.org/10.1039/c2ob25100k","title":"The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments","display_name":"The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1964445501","doi":"https://doi.org/10.1039/c2ob25100k","mag":"1964445501","pmid":"https://pubmed.ncbi.nlm.nih.gov/22504866"},"language":"en","primary_location":{"id":"doi:10.1039/c2ob25100k","doi":"https://doi.org/10.1039/c2ob25100k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c2ob25100k","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016051848","display_name":"Ian Paterson","orcid":"https://orcid.org/0000-0002-8861-9136","observed_orcids":["https://orcid.org/0000-0002-8861-9136"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ian Paterson","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk","University Chemical Laboratory University of Cambridge Lensfield Road Cambridge CB2 1EW UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University Chemical Laboratory University of Cambridge Lensfield Road Cambridge CB2 1EW UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088141048","display_name":"Edward A. Anderson","orcid":"https://orcid.org/0000-0002-4149-0494","observed_orcids":["https://orcid.org/0000-0002-4149-0494"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edward A. Anderson","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089034933","display_name":"Stephen M. Dalby","orcid":"https://orcid.org/0000-0002-9953-6432","observed_orcids":["https://orcid.org/0000-0002-9953-6432"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen M. Dalby","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101055593","display_name":"Jong Ho Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jong Ho Lim","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046365595","display_name":"Philip Maltas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip Maltas","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054695305","display_name":"Olivier Loiseleur","orcid":"https://orcid.org/0000-0002-1012-4299","observed_orcids":["https://orcid.org/0000-0002-1012-4299"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olivier Loiseleur","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039778021","display_name":"Julien Genovino","orcid":"https://orcid.org/0000-0001-5879-2491","observed_orcids":["https://orcid.org/0000-0001-5879-2491"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julien Genovino","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054310923","display_name":"Christian Moessner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christian Moessner","raw_affiliation_strings":["University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016051848"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":2.0502,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.85002576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"30","first_page":"5861","last_page":"5861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.421099990606308,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.421099990606308,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.06390000134706497,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/stereoselective-synthesis","display_name":"stereoselective synthesis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/modular-synthesis","display_name":"modular synthesis","score":0.5180000066757202},{"id":"https://openalex.org/keywords/marine-sponge-natural-products","display_name":"marine sponge natural products","score":0.7379999756813049},{"id":"https://openalex.org/keywords/sharpless-asymmetric-dihydroxylation","display_name":"Sharpless asymmetric dihydroxylation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/vinyl-iodides","display_name":"vinyl iodides","score":0.7409999966621399},{"id":"https://openalex.org/keywords/vinylstannanes","display_name":"vinylstannanes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tetrahydropyran","display_name":"tetrahydropyran","score":0.7200000286102295},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.784529447555542},{"id":"https://openalex.org/C2776626252","wikidata":"https://www.wikidata.org/wiki/Q752651","display_name":"Sharpless asymmetric dihydroxylation","level":4,"score":0.7696807384490967},{"id":"https://openalex.org/C2777728192","wikidata":"https://www.wikidata.org/wiki/Q412815","display_name":"Tetrahydropyran","level":3,"score":0.6659424304962158},{"id":"https://openalex.org/C61156836","wikidata":"https://www.wikidata.org/wiki/Q494392","display_name":"Aldol reaction","level":3,"score":0.58082115650177},{"id":"https://openalex.org/C2777731525","wikidata":"https://www.wikidata.org/wiki/Q421103","display_name":"Acetal","level":2,"score":0.5498752593994141},{"id":"https://openalex.org/C2777897746","wikidata":"https://www.wikidata.org/wiki/Q417040","display_name":"Stannane","level":2,"score":0.5446897745132446},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5104019045829773},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.4628559648990631},{"id":"https://openalex.org/C2780588603","wikidata":"https://www.wikidata.org/wiki/Q3589015","display_name":"Enyne","level":3,"score":0.44186514616012573},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.41847991943359375},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.37253129482269287},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33499258756637573},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.27240923047065735},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24247828125953674},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.10956436395645142},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07549473643302917},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000480","descriptor_name":"Alkynes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014753","descriptor_name":"Vinyl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017971","descriptor_name":"Tin Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060326","descriptor_name":"Chemistry Techniques, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c2ob25100k","doi":"https://doi.org/10.1039/c2ob25100k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c2ob25100k","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},{"id":"pmid:22504866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22504866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G611800245","display_name":null,"funder_award_id":"EP/C541677/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1504523189","https://openalex.org/W1553908537","https://openalex.org/W1963809796","https://openalex.org/W1964719724","https://openalex.org/W1967000579","https://openalex.org/W1967266228","https://openalex.org/W1967717771","https://openalex.org/W1972554674","https://openalex.org/W1974258770","https://openalex.org/W1977602563","https://openalex.org/W1977915889","https://openalex.org/W1978890358","https://openalex.org/W1979144561","https://openalex.org/W1979813798","https://openalex.org/W1981130165","https://openalex.org/W1983555000","https://openalex.org/W1986233198","https://openalex.org/W1987695251","https://openalex.org/W1993289104","https://openalex.org/W1994524513","https://openalex.org/W1997458480","https://openalex.org/W2002050138","https://openalex.org/W2003210432","https://openalex.org/W2006552313","https://openalex.org/W2010113191","https://openalex.org/W2010871897","https://openalex.org/W2017055412","https://openalex.org/W2021821023","https://openalex.org/W2024748066","https://openalex.org/W2025315437","https://openalex.org/W2026926851","https://openalex.org/W2030055085","https://openalex.org/W2030862186","https://openalex.org/W2033224436","https://openalex.org/W2035014780","https://openalex.org/W2036931279","https://openalex.org/W2038723338","https://openalex.org/W2038798777","https://openalex.org/W2041769371","https://openalex.org/W2043629214","https://openalex.org/W2045463233","https://openalex.org/W2048407273","https://openalex.org/W2054378884","https://openalex.org/W2057157158","https://openalex.org/W2057164485","https://openalex.org/W2057332886","https://openalex.org/W2057628256","https://openalex.org/W2062731956","https://openalex.org/W2071098418","https://openalex.org/W2072626598","https://openalex.org/W2081966254","https://openalex.org/W2082746388","https://openalex.org/W2084699035","https://openalex.org/W2090557812","https://openalex.org/W2092683059","https://openalex.org/W2100959093","https://openalex.org/W2105718579","https://openalex.org/W2105879297","https://openalex.org/W2109261012","https://openalex.org/W2110506537","https://openalex.org/W2112200517","https://openalex.org/W2115681043","https://openalex.org/W2120562087","https://openalex.org/W2121755458","https://openalex.org/W2122749807","https://openalex.org/W2126022387","https://openalex.org/W2132137399","https://openalex.org/W2135193488","https://openalex.org/W2140559850","https://openalex.org/W2141443110","https://openalex.org/W2141474275","https://openalex.org/W2151485760","https://openalex.org/W2155372433","https://openalex.org/W2155588097","https://openalex.org/W2156997087","https://openalex.org/W2160041016","https://openalex.org/W2161550840","https://openalex.org/W2165408960","https://openalex.org/W2166739408","https://openalex.org/W2169295501","https://openalex.org/W2313545838","https://openalex.org/W2814316800","https://openalex.org/W2949199729","https://openalex.org/W2949452828","https://openalex.org/W2949524828","https://openalex.org/W2949560289","https://openalex.org/W2949648871","https://openalex.org/W2950017324","https://openalex.org/W2950598269","https://openalex.org/W2951407685","https://openalex.org/W2951585006","https://openalex.org/W2951633443","https://openalex.org/W2951938555","https://openalex.org/W2952434506","https://openalex.org/W2953011238","https://openalex.org/W2953167919","https://openalex.org/W4250839705","https://openalex.org/W7213332644"],"related_works":["https://openalex.org/W1977602563","https://openalex.org/W1967266228","https://openalex.org/W2117582597","https://openalex.org/W2814316800","https://openalex.org/W2951938555","https://openalex.org/W2141443110","https://openalex.org/W2038559364","https://openalex.org/W2036735568","https://openalex.org/W2115555537","https://openalex.org/W2160041016"],"abstract_inverted_index":{"Due":[0],"to":[1,123,131,143,156],"a":[2,59,87,95,128,137,164,168],"combination":[3],"of":[4,34,58,61,71,74,119,173,192],"their":[5,17],"promising":[6],"anticancer":[7],"properties,":[8],"limited":[9],"supply":[10],"from":[11,199],"the":[12,32,42,47,54,72,100,125,133,145,158,193],"marine":[13],"sponge":[14],"source":[15],"and":[16,24,102,136,147],"unprecedented":[18],"molecular":[19],"architecture,":[20],"spirastrellolides":[21],"represent":[22],"attractive":[23],"challenging":[25],"synthetic":[26],"targets.":[27],"A":[28,36,111],"modular":[29],"strategy":[30],"for":[31,41,190],"synthesis":[33,73],"spirastrellolide":[35],"methyl":[37],"ester,":[38],"which":[39,174],"allowed":[40],"initial":[43],"stereochemical":[44],"uncertainties":[45],"in":[46,65],"assigned":[48],"structure":[49],"was":[50,84,115,175,197],"adopted,":[51],"based":[52],"on":[53,94],"envisaged":[55],"sequential":[56],"coupling":[57,152],"series":[60],"suitably":[62,107],"functionalised":[63],"fragments;":[64],"this":[66],"first":[67],"paper,":[68],"full":[69],"details":[70],"these":[75],"fragments":[76],"are":[77],"described.":[78],"The":[79,183],"pivotal":[80],"C26-C40":[81,159],"DEF":[82,160],"bis-spiroacetal":[83],"assembled":[85],"by":[86,117],"double":[88],"Sharpless":[89],"asymmetric":[90],"dihydroxylation/acetalisation":[91],"cascade":[92],"process":[93],"linear":[96],"diene":[97],"intermediate,":[98],"configuring":[99],"C31":[101],"C35":[103],"acetal":[104],"centres":[105],"under":[106],"mild":[108],"acidic":[109],"conditions.":[110],"C1-C16":[112],"alkyne":[113],"fragment":[114,188],"constructed":[116],"application":[118],"an":[120,178],"oxy-Michael":[121],"reaction":[122],"introduce":[124],"A-ring":[126],"tetrahydropyran,":[127],"Sakurai":[129],"allylation":[130],"install":[132],"C9":[134],"hydroxyl,":[135],"1,4-syn":[138],"boron":[139],"aldol/directed":[140],"reduction":[141],"sequence":[142],"establish":[144],"C11":[146],"C13":[148],"stereocentres.":[149],"Two":[150],"different":[151],"strategies":[153],"were":[154],"investigated":[155],"elaborate":[157],"fragment,":[161],"involving":[162],"either":[163],"C17-C25":[165],"sulfone":[166],"or":[167],"C17-C24":[169],"vinyl":[170,186],"iodide,":[171],"each":[172],"prepared":[176,198],"using":[177],"Evans":[179],"glycolate":[180],"aldol":[181],"reaction.":[182],"remaining":[184],"C43-C47":[185],"stannane":[187],"required":[189],"introduction":[191],"unsaturated":[194],"side":[195],"chain":[196],"(R)-malic":[200],"acid.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}