{"id":"https://openalex.org/W1964435637","doi":"https://doi.org/10.1161/01.res.74.6.1121","title":"Methylene blue reverses endotoxin-induced hypotension.","display_name":"Methylene blue reverses endotoxin-induced hypotension.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W1964435637","doi":"https://doi.org/10.1161/01.res.74.6.1121","mag":"1964435637","pmid":"https://pubmed.ncbi.nlm.nih.gov/8187278"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.74.6.1121","doi":"https://doi.org/10.1161/01.res.74.6.1121","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.74.6.1121","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.74.6.1121","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.74.6.1121","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048859763","display_name":"John F. Keaney","orcid":"https://orcid.org/0000-0002-0866-1837","observed_orcids":["https://orcid.org/0000-0002-0866-1837"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Keaney","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Mass","J F KeaneyJr Department of Medicine, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"J F KeaneyJr Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056497705","display_name":"Juan Carlos Puyana","orcid":"https://orcid.org/0000-0003-4284-4693","observed_orcids":["https://orcid.org/0000-0003-4284-4693"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Puyana","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Mass","J C Puyana Department of Medicine, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"J C Puyana Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Francis","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Mass","S Francis Department of Medicine, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"S Francis Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J F Loscalzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Loscalzo","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Mass","J F Loscalzo Department of Medicine, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"J F Loscalzo Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060088000","display_name":"Jonathan S. Stamler","orcid":"https://orcid.org/0000-0002-6866-1572","observed_orcids":["https://orcid.org/0000-0002-6866-1572"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Stamler","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Mass","J S Stamler Department of Medicine, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"J S Stamler Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":null,"display_name":"J Loscalzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Loscalzo","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Mass","J Loscalzo Department of Medicine, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"J Loscalzo Department of Medicine, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":8.5692,"has_fulltext":true,"cited_by_count":107,"citation_normalized_percentile":{"value":0.98299955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"74","issue":"6","first_page":"1121","last_page":"1125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.996999979019165},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.6710000038146973},{"id":"https://openalex.org/keywords/s-nitrosothiols","display_name":"S-nitrosothiols","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.8925175666809082},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.7488514184951782},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.7093871235847473},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6054835319519043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5668991208076477},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5520421266555786},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5361307859420776},{"id":"https://openalex.org/C2778827303","wikidata":"https://www.wikidata.org/wiki/Q7558945","display_name":"Soluble guanylyl cyclase","level":4,"score":0.5075629949569702},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.47112345695495605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4231465458869934},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4193218946456909},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40823668241500854},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.39625298976898193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3708377480506897},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.28198376297950745},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.28037023544311523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18196329474449158},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.17441809177398682},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.74.6.1121","doi":"https://doi.org/10.1161/01.res.74.6.1121","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.74.6.1121","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.74.6.1121","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:8187278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8187278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"mag:3146139680","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/res.74.6.8187278","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation Research","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.res.74.6.1121","doi":"https://doi.org/10.1161/01.res.74.6.1121","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.74.6.1121","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.74.6.1121","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2134540356","display_name":null,"funder_award_id":"HL43344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3880250282","display_name":null,"funder_award_id":"HL-40411","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G554591323","display_name":"PROTHROMBOTIC EFFECTS OF LIPOPROTEIN","funder_award_id":"R01HL043344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6273422239","display_name":"PLATELETS, PLATELET AGGREGATES &PLASMINOGEN ACTIVATION","funder_award_id":"R01HL040411","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G688846317","display_name":null,"funder_award_id":"HL-48743","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8284249587","display_name":"Arterial Dysfunction: Basic and Clinical Mechanisms","funder_award_id":"P01HL048743","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964435637.pdf","grobid_xml":"https://content.openalex.org/works/W1964435637.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W43833714","https://openalex.org/W1516582678","https://openalex.org/W1541963905","https://openalex.org/W1594268419","https://openalex.org/W1675755394","https://openalex.org/W1903381892","https://openalex.org/W1907994445","https://openalex.org/W1922132784","https://openalex.org/W1987499931","https://openalex.org/W1995907867","https://openalex.org/W2000075945","https://openalex.org/W2002192155","https://openalex.org/W2010489806","https://openalex.org/W2017663495","https://openalex.org/W2021117769","https://openalex.org/W2024283446","https://openalex.org/W2031383268","https://openalex.org/W2035988892","https://openalex.org/W2037768305","https://openalex.org/W2040893865","https://openalex.org/W2041358315","https://openalex.org/W2044263892","https://openalex.org/W2044918962","https://openalex.org/W2058056447","https://openalex.org/W2059141308","https://openalex.org/W2059379142","https://openalex.org/W2072204309","https://openalex.org/W2081759103","https://openalex.org/W2093220509","https://openalex.org/W2093518775","https://openalex.org/W2121105123","https://openalex.org/W2122717768","https://openalex.org/W2126215854","https://openalex.org/W2151820575","https://openalex.org/W2171686436","https://openalex.org/W2258411363","https://openalex.org/W2263056392","https://openalex.org/W2319070317","https://openalex.org/W2334629896","https://openalex.org/W2408905379","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2065693083","https://openalex.org/W2087266923","https://openalex.org/W2093890269","https://openalex.org/W2080202928","https://openalex.org/W1531042322","https://openalex.org/W2022306974","https://openalex.org/W2061525475","https://openalex.org/W4391879459","https://openalex.org/W2043126816","https://openalex.org/W2027390756"],"abstract_inverted_index":{"Hypotension":[0],"in":[1,31,73,79,124,151,180,218],"septic":[2,183,231],"shock":[3,30],"is":[4,187],"a":[5,76,120,223],"reflection":[6],"of":[7,24,43,65,113,155,192,198,211,216,230],"unregulated":[8],"nitric":[9],"oxide":[10],"(NO)":[11],"production":[12],"and":[13,49,60,68,116,135,196,221],"vascular":[14],"smooth":[15],"muscle":[16],"guanylyl":[17],"cyclase":[18],"activation.":[19],"We":[20],"examined":[21],"the":[22,62,228],"effect":[23,186],"methylene":[25,71,164,174,208],"blue":[26,72,110,165,175],"on":[27],"lipopolysaccharide":[28],"(LPS)-induced":[29],"anesthetized":[32],"rabbits.":[33],"Shock":[34],"was":[35,90],"induced":[36],"with":[37,153,182,189,207],"150":[38],"micrograms/kg":[39],"LPS":[40,105],"after":[41,61,104,149],"measurement":[42],"mean":[44,80,85,125,146],"arterial":[45,81,88,126,147,178],"pressure,":[46],"platelet":[47],"cGMP,":[48],"total":[50,157,199],"plasma":[51,156,200],"NO":[52,158,201,212,217],"(nitrogen":[53],"monoxide+S-nitrosothiol)":[54],"content.":[55,202],"Measurements":[56],"were":[57],"repeated":[58],"before":[59],"intravenous":[63],"administration":[64],"1,":[66,114],"5,":[67,115],"10":[69,117],"mg/kg":[70,118],"response":[74],"to":[75,98,128,227],"55%":[77],"reduction":[78],"pressure.":[82],"At":[83],"baseline,":[84],"+/-":[86,92,100,130,133,137],"SEM":[87],"pressure":[89,127,148,179],"88":[91],"3":[93,101],"mm":[94,102,139],"Hg,":[95,140],"which":[96],"fell":[97],"51":[99],"Hg":[103],"(P":[106,142,160],"<":[107,143,161],".05).":[108],"Methylene":[109],"at":[111],"doses":[112],"produced":[119],"prompt":[121],"dose-dependent":[122],"increase":[123],"69":[129],"2,":[131],"77":[132],"3,":[134],"81":[136],"2":[138],"respectively":[141],".05":[144],"versus":[145],"LPS)":[150],"association":[152],"normalization":[154,197],"content":[159],".05);":[162],"however,":[163],"did":[166],"not":[167],"significantly":[168],"affect":[169],"intraplatelet":[170,193],"cGMP":[171,194],"levels.":[172],"Thus,":[173],"restores":[176],"normal":[177],"rabbits":[181],"shock.":[184,232],"This":[185],"associated":[188],"persistent":[190],"elevation":[191],"levels":[195],"These":[203],"data":[204],"are":[205],"consistent":[206],"blue-mediated":[209],"inhibition":[210],"synthase":[213],"and/or":[214],"degradation":[215],"this":[219],"model":[220],"suggest":[222],"novel":[224],"therapeutic":[225],"approach":[226],"treatment":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}