{"id":"https://openalex.org/W1964409752","doi":"https://doi.org/10.1007/s00280-010-1311-3","title":"Phase II study of S-1 in patients with gemcitabine-resistant advanced pancreatic cancer","display_name":"Phase II study of S-1 in patients with gemcitabine-resistant advanced pancreatic cancer","publication_year":2010,"publication_date":"2010-03-29","ids":{"openalex":"https://openalex.org/W1964409752","doi":"https://doi.org/10.1007/s00280-010-1311-3","mag":"1964409752","pmid":"https://pubmed.ncbi.nlm.nih.gov/20352216"},"language":"en","primary_location":{"id":"doi:10.1007/s00280-010-1311-3","doi":"https://doi.org/10.1007/s00280-010-1311-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00280-010-1311-3","pdf_url":null,"source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113641425","display_name":"Kentaro Sudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Sudo","raw_affiliation_strings":["Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8617, Japan. kentarosudo9@yahoo.co.jp","Chiba Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8617, Japan. kentarosudo9@yahoo.co.jp","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"Chiba Cancer Center","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068601802","display_name":"Taketo Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taketo Yamaguchi","raw_affiliation_strings":["Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","Chiba Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"Chiba Cancer Center","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105825409","display_name":"Kazuyoshi Nakamura","orcid":"https://orcid.org/0000-0003-0516-8913","observed_orcids":["https://orcid.org/0000-0003-0516-8913"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Nakamura","raw_affiliation_strings":["Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","Chiba Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"Chiba Cancer Center","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053544331","display_name":"Tadamichi Denda","orcid":"https://orcid.org/0000-0003-2570-9692","observed_orcids":["https://orcid.org/0000-0003-2570-9692"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadamichi Denda","raw_affiliation_strings":["Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","Chiba Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"Chiba Cancer Center","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109413829","display_name":"Taro Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taro Hara","raw_affiliation_strings":["Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","Chiba Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8617, Japan","institution_ids":["https://openalex.org/I4210115246"]},{"raw_affiliation_string":"Chiba Cancer Center","institution_ids":["https://openalex.org/I4210115246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032775863","display_name":"Takeshi Ishihara","orcid":"https://orcid.org/0000-0002-7429-4756","observed_orcids":["https://orcid.org/0000-0002-7429-4756"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Ishihara","raw_affiliation_strings":["Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan","Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102927536","display_name":"Osamu Yokosuka","orcid":"https://orcid.org/0000-0002-1763-9439","observed_orcids":["https://orcid.org/0000-0002-1763-9439"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Yokosuka","raw_affiliation_strings":["Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan","Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Chiba University","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113641425"],"corresponding_institution_ids":["https://openalex.org/I4210115246"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":3.2476,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.92217488,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"67","issue":"2","first_page":"249","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tegafur-uracil","display_name":"tegafur-uracil","score":0.8389999866485596},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.8809999823570251},{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oral-chemotherapy","display_name":"oral chemotherapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.9079999923706055},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9430000185966492},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9562011957168579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8939238786697388},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7646307945251465},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.689018189907074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6818709969520569},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5948486924171448},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5409196019172668},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48746395111083984},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.47496506571769714},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4736833870410919},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.47148582339286804},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4599001407623291},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.4481545686721802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4432690441608429},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35273832082748413},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.19612234830856323},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018395","descriptor_name":"CA-19-9 Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00280-010-1311-3","doi":"https://doi.org/10.1007/s00280-010-1311-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00280-010-1311-3","pdf_url":null,"source":{"id":"https://openalex.org/S117498271","display_name":"Cancer Chemotherapy and Pharmacology","issn_l":"0344-5704","issn":["0344-5704","1432-0843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Chemotherapy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:20352216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20352216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer chemotherapy and pharmacology","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W61003746","https://openalex.org/W1931508686","https://openalex.org/W1972107936","https://openalex.org/W1978502285","https://openalex.org/W1998855245","https://openalex.org/W2018619890","https://openalex.org/W2019438357","https://openalex.org/W2024598695","https://openalex.org/W2031116585","https://openalex.org/W2040065840","https://openalex.org/W2043843434","https://openalex.org/W2064792760","https://openalex.org/W2065064849","https://openalex.org/W2067141748","https://openalex.org/W2077902459","https://openalex.org/W2082243630","https://openalex.org/W2114680879","https://openalex.org/W2131926022","https://openalex.org/W2138040686","https://openalex.org/W2230554281","https://openalex.org/W3009325102","https://openalex.org/W4238493616"],"related_works":["https://openalex.org/W2242399775","https://openalex.org/W2024598695","https://openalex.org/W2009325232","https://openalex.org/W2600149174","https://openalex.org/W2222091014","https://openalex.org/W2156920992","https://openalex.org/W4231243209","https://openalex.org/W1995709092","https://openalex.org/W2387695600","https://openalex.org/W2601115157"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
