{"id":"https://openalex.org/W1964324370","doi":"https://doi.org/10.1016/s0092-8674(00)80767-9","title":"BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-\u03b1 Factor across the ER Membrane","display_name":"BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-\u03b1 Factor across the ER Membrane","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W1964324370","doi":"https://doi.org/10.1016/s0092-8674(00)80767-9","mag":"1964324370","pmid":"https://pubmed.ncbi.nlm.nih.gov/10367885"},"language":"en","primary_location":{"id":"doi:10.1016/s0092-8674(00)80767-9","doi":"https://doi.org/10.1016/s0092-8674(00)80767-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(00)80767-9","pdf_url":"http://www.cell.com/article/S0092867400807679/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867400807679/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052384779","display_name":"Kent E. S. Matlack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent E.S Matlack","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054681942","display_name":"Benjamin Misselwitz","orcid":"https://orcid.org/0000-0002-8719-5175","observed_orcids":["https://orcid.org/0000-0002-8719-5175"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Misselwitz","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017513011","display_name":"Kathrin Plath","orcid":"https://orcid.org/0000-0001-7796-3372","observed_orcids":["https://orcid.org/0000-0001-7796-3372"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathrin Plath","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087757787","display_name":"Tom A. Rapoport","orcid":"https://orcid.org/0000-0001-9911-4216","observed_orcids":["https://orcid.org/0000-0001-9911-4216"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tom A Rapoport","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115-6091, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087757787"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":8.4682,"has_fulltext":false,"cited_by_count":440,"citation_normalized_percentile":{"value":0.98674943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"97","issue":"5","first_page":"553","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.13379999995231628,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bip","display_name":"BiP","score":0.871999979019165},{"id":"https://openalex.org/keywords/kar2p","display_name":"Kar2p","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8700000047683716},{"id":"https://openalex.org/keywords/molecular-ratchets","display_name":"molecular ratchets","score":0.7870000004768372},{"id":"https://openalex.org/keywords/j-domain","display_name":"J-domain","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-membrane","display_name":"endoplasmic reticulum membrane","score":0.8759999871253967},{"id":"https://openalex.org/keywords/brownian-ratchet","display_name":"Brownian ratchet","score":0.8270000219345093},{"id":"https://openalex.org/keywords/secretory-protein-transport","display_name":"secretory protein transport","score":0.5239999890327454},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8257039189338684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7848056554794312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5729771256446838},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5486201047897339},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.5191080570220947},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.48362627625465393},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4537440240383148},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.4390505850315094},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3555574417114258},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3345297873020172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2941244840621948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06845664978027344}],"mesh":[{"descriptor_ui":"D000072235","descriptor_name":"Mating Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0092-8674(00)80767-9","doi":"https://doi.org/10.1016/s0092-8674(00)80767-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(00)80767-9","pdf_url":"http://www.cell.com/article/S0092867400807679/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:10367885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10367885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.453.6279","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.453.6279","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://mcb.berkeley.edu/labs/krantz/pdf/Matlack_etal-BiP_molecular_ratchet-Cell-1999.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/s0092-8674(00)80767-9","doi":"https://doi.org/10.1016/s0092-8674(00)80767-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0092-8674(00)80767-9","pdf_url":"http://www.cell.com/article/S0092867400807679/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1319813161","display_name":"POSTTRANSLATIONAL PROTEIN TRANSPORT INTO YEAST ER","funder_award_id":"R01GM054238","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2345979694","display_name":null,"funder_award_id":"GM54238","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1964324370.pdf"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1963770237","https://openalex.org/W1965901600","https://openalex.org/W1973463353","https://openalex.org/W1980669547","https://openalex.org/W1984188958","https://openalex.org/W1984685964","https://openalex.org/W1992271142","https://openalex.org/W2014741617","https://openalex.org/W2020070027","https://openalex.org/W2022572800","https://openalex.org/W2022936503","https://openalex.org/W2026811970","https://openalex.org/W2027484457","https://openalex.org/W2034176931","https://openalex.org/W2034692794","https://openalex.org/W2037464535","https://openalex.org/W2050741966","https://openalex.org/W2051141018","https://openalex.org/W2062634373","https://openalex.org/W2071748696","https://openalex.org/W2076021340","https://openalex.org/W2076945013","https://openalex.org/W2088264371","https://openalex.org/W2094197811","https://openalex.org/W2103778190","https://openalex.org/W2106635066","https://openalex.org/W2111538369","https://openalex.org/W2118016880","https://openalex.org/W2118278390","https://openalex.org/W2124761552","https://openalex.org/W2132103617","https://openalex.org/W2138158290","https://openalex.org/W2186927063","https://openalex.org/W2688325281"],"related_works":["https://openalex.org/W7099227911","https://openalex.org/W2014199958","https://openalex.org/W1984685964","https://openalex.org/W2132103617","https://openalex.org/W2162791176","https://openalex.org/W7097267893","https://openalex.org/W2062634373","https://openalex.org/W2101557398","https://openalex.org/W2105568907","https://openalex.org/W2106635066"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}