{"id":"https://openalex.org/W1964311602","doi":"https://doi.org/10.1074/jbc.272.35.21681","title":"Phosphorylation of the Tumor Suppressor Adenomatous Polyposis Coli (APC) by the Cyclin-dependent Kinase p34","display_name":"Phosphorylation of the Tumor Suppressor Adenomatous Polyposis Coli (APC) by the Cyclin-dependent Kinase p34","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W1964311602","doi":"https://doi.org/10.1074/jbc.272.35.21681","mag":"1964311602","pmid":"https://pubmed.ncbi.nlm.nih.gov/9268294"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.35.21681","doi":"https://doi.org/10.1074/jbc.272.35.21681","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.35.21681","pdf_url":"http://www.jbc.org/article/S0021925819656097/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819656097/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018703856","display_name":"Chris Trzepacz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Trzepacz","raw_affiliation_strings":["Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA","Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089839809","display_name":"Andrew M. Lowy","orcid":"https://orcid.org/0000-0002-7106-0735","observed_orcids":["https://orcid.org/0000-0002-7106-0735"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Lowy","raw_affiliation_strings":["Departments of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088606427","display_name":"Jennifer J. Kordich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer J. Kordich","raw_affiliation_strings":["Departments of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088753285","display_name":"Joanna Louise Groden","orcid":"https://orcid.org/0000-0001-8507-6423","observed_orcids":["https://orcid.org/0000-0001-8507-6423"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joanna Groden","raw_affiliation_strings":["Departments of Molecular Genetics, Biochemistry & Microbiology, Cincinnati, Ohio 45267"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Genetics, Biochemistry & Microbiology, Cincinnati, Ohio 45267","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088753285"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3185,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.88738073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"272","issue":"35","first_page":"21681","last_page":"21684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenomatous-polyposis-coli","display_name":"adenomatous polyposis coli","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apc-tumor-suppressor","display_name":"APC tumor suppressor","score":0.8640000224113464},{"id":"https://openalex.org/keywords/p34cdc2","display_name":"p34cdc2","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.968999981880188},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/c-terminal-region","display_name":"C-terminal region","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.7947434782981873},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.7165888547897339},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.6591750979423523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5856103897094727},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.5637915134429932},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.5500380992889404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5444633960723877},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49723318219184875},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4739775061607361},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4736909866333008},{"id":"https://openalex.org/C51853150","wikidata":"https://www.wikidata.org/wiki/Q14911754","display_name":"Cyclin-dependent kinase 4","level":5,"score":0.4451877176761627},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.43302756547927856},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.38143083453178406},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.3544175624847412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32439422607421875},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.29219871759414673},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.27594414353370667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18928462266921997},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16659143567085266},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14858940243721008},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14653223752975464},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07630005478858948}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007701","descriptor_name":"Kinetin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011125","descriptor_name":"Adenomatous Polyposis Coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.35.21681","doi":"https://doi.org/10.1074/jbc.272.35.21681","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.35.21681","pdf_url":"http://www.jbc.org/article/S0021925819656097/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9268294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9268294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.35.21681","doi":"https://doi.org/10.1074/jbc.272.35.21681","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.35.21681","pdf_url":"http://www.jbc.org/article/S0021925819656097/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1583686105","display_name":null,"funder_award_id":"CA63507","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306470","display_name":"Elsa U. Pardee Foundation","ror":"https://ror.org/05sjnvv07"},{"id":"https://openalex.org/F4320307443","display_name":"Albert J. Ryan Foundation","ror":"https://ror.org/04pza9565"},{"id":"https://openalex.org/F4320311351","display_name":"American Gastroenterological Association","ror":"https://ror.org/00y65x556"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964311602.pdf","grobid_xml":"https://content.openalex.org/works/W1964311602.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1515355112","https://openalex.org/W1546151374","https://openalex.org/W1546492519","https://openalex.org/W1809606297","https://openalex.org/W1967137553","https://openalex.org/W1967243795","https://openalex.org/W1975993620","https://openalex.org/W1979618971","https://openalex.org/W1979855911","https://openalex.org/W1994539742","https://openalex.org/W2029247990","https://openalex.org/W2039661491","https://openalex.org/W2059813946","https://openalex.org/W2071377606","https://openalex.org/W2078462484","https://openalex.org/W2081758458","https://openalex.org/W2082387343","https://openalex.org/W2085252478","https://openalex.org/W2087386654","https://openalex.org/W2089528428","https://openalex.org/W2093531978","https://openalex.org/W2118184847","https://openalex.org/W2146167376","https://openalex.org/W2406485009"],"related_works":["https://openalex.org/W293660901","https://openalex.org/W1980039360","https://openalex.org/W2017836439","https://openalex.org/W2078462484","https://openalex.org/W2087386654","https://openalex.org/W7213534706","https://openalex.org/W2164055070","https://openalex.org/W7099450812","https://openalex.org/W7095748035","https://openalex.org/W1967137553"],"abstract_inverted_index":{"Mutations":[0],"in":[1,26,42,85],"the":[2,10,43,60,95,98,132],"tumor":[3],"suppressor":[4],"gene":[5],"APC":[6,29,63,78,105,116,126],"invariably":[7],"lead":[8],"to":[9,64,131],"development":[11],"of":[12,18,48,51,62,73,91,97,115],"colorectal":[13],"cancer.":[14],"The":[15],"vast":[16],"majority":[17],"these":[19,52,92],"mutations":[20],"are":[21],"nonsense":[22],"or":[23],"frameshifts":[24],"resulting":[25],"nonfunctional,":[27],"truncated":[28],"protein":[30,79],"products.":[31],"Eleven":[32],"cyclin-dependent":[33],"kinase":[34,83],"(CDK)":[35],"consensus":[36],"phosphorylation":[37,53,120],"sites":[38,54],"have":[39],"been":[40],"identified":[41],"frequently":[44],"deleted":[45],"carboxyl-terminal":[46],"region":[47],"APC;":[49],"loss":[50],"by":[55,117],"mutation":[56],"could":[57],"therefore":[58],"compromise":[59],"ability":[61],"inhibit":[65],"cell":[66,133],"growth.":[67],"This":[68],"report":[69],"demonstrates":[70],"that":[71,104],"immunoprecipitates":[72,93],"full-length,":[74],"but":[75],"not":[76],"truncated,":[77],"include":[80],"a":[81,107,122,129],"mitosis-specific":[82],"activity":[84],"vivo.":[86],"Biochemical":[87],"and":[88],"Western":[89],"analysis":[90],"confirms":[94],"presence":[96],"CDK":[99],"p34(cdc2).":[100],"We":[101],"also":[102],"show":[103],"is":[106],"substrate":[108],"for":[109,124],"recombinant":[110],"human":[111],"p34(cdc2)-cyclin":[112],"B1.":[113],"Modification":[114],"p34(cdc2)":[118],"implicates":[119],"as":[121],"mechanism":[123],"regulating":[125],"function":[127],"via":[128],"link":[130],"cycle.":[134]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
