{"id":"https://openalex.org/W1964300433","doi":"https://doi.org/10.1053/j.gastro.2007.03.104","title":"Monoclonal Anti\u2013Interleukin 23 Reverses Active Colitis in a T Cell\u2013Mediated Model in Mice","display_name":"Monoclonal Anti\u2013Interleukin 23 Reverses Active Colitis in a T Cell\u2013Mediated Model in Mice","publication_year":2007,"publication_date":"2007-04-17","ids":{"openalex":"https://openalex.org/W1964300433","doi":"https://doi.org/10.1053/j.gastro.2007.03.104","mag":"1964300433","pmid":"https://pubmed.ncbi.nlm.nih.gov/17570211"},"language":"en","primary_location":{"id":"doi:10.1053/j.gastro.2007.03.104","doi":"https://doi.org/10.1053/j.gastro.2007.03.104","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.gastro.2007.03.104","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016132909","display_name":"Charles O. Elson","orcid":"https://orcid.org/0000-0001-8873-1534","observed_orcids":["https://orcid.org/0000-0001-8873-1534"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles O. Elson","raw_affiliation_strings":["Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA. coelson@uab.edu","Department of Medicine-University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA. coelson@uab.edu","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Medicine-University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006930837","display_name":"Yingzi Cong","orcid":"https://orcid.org/0000-0003-4167-7395","observed_orcids":["https://orcid.org/0000-0003-4167-7395"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingzi Cong","raw_affiliation_strings":["Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028913632","display_name":"Casey Todd Weaver","orcid":"https://orcid.org/0000-0002-2180-1793","observed_orcids":["https://orcid.org/0000-0002-2180-1793"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey T. Weaver","raw_affiliation_strings":["Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054883733","display_name":"Trenton R. Schoeb","orcid":"https://orcid.org/0000-0001-9137-5462","observed_orcids":["https://orcid.org/0000-0001-9137-5462"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trenton R. Schoeb","raw_affiliation_strings":["Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011197905","display_name":"Terrill K. McClanahan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terrill K. McClanahan","raw_affiliation_strings":["Schering-Plough Biopharma, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Biopharma, Palo Alto, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003378467","display_name":"Robert B. Fick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B. Fick","raw_affiliation_strings":["Schering-Plough Biopharma, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Biopharma, Palo Alto, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103497871","display_name":"Robert A. Kastelein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Kastelein","raw_affiliation_strings":["Schering-Plough Biopharma, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Biopharma, Palo Alto, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016132909"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":40.5507,"has_fulltext":false,"cited_by_count":456,"citation_normalized_percentile":{"value":0.99911635,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"132","issue":"7","first_page":"2359","last_page":"2370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.9629999995231628},{"id":"https://openalex.org/keywords/il-23p19","display_name":"IL-23p19","score":0.8989999890327454},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.7390000224113464},{"id":"https://openalex.org/keywords/chronic-colitis","display_name":"chronic colitis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anti-il-23-monoclonal-antibody","display_name":"anti-IL-23 monoclonal antibody","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lamina-propria-inflammation","display_name":"lamina propria inflammation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.656000018119812},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.41499999165534973},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6620000004768372},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.583074688911438},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.522024929523468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4881068170070648},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48312684893608093},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4619396924972534},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0468345582485199}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/j.gastro.2007.03.104","doi":"https://doi.org/10.1053/j.gastro.2007.03.104","is_oa":false,"landing_page_url":"https://doi.org/10.1053/j.gastro.2007.03.104","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:17570211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17570211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3639976226","display_name":"Mucosal HIV and Immunobiology Center","funder_award_id":"R24DK064400","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G388801721","display_name":"INNATE AND ADAPTIVE IMMUNITY IN IBD","funder_award_id":"P01DK071176","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G911264376","display_name":"CHRONIC INTESTINAL INFLAMMATION--MECHANISMS AND EFFECTS","funder_award_id":"P01DK044240","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1505685427","https://openalex.org/W1514253734","https://openalex.org/W1584352387","https://openalex.org/W1585461212","https://openalex.org/W1702969026","https://openalex.org/W1752167169","https://openalex.org/W1832936335","https://openalex.org/W1930189007","https://openalex.org/W1954354169","https://openalex.org/W1966999437","https://openalex.org/W1972926790","https://openalex.org/W1980668544","https://openalex.org/W1987628377","https://openalex.org/W1988975884","https://openalex.org/W2006249161","https://openalex.org/W2014359739","https://openalex.org/W2025484368","https://openalex.org/W2047409274","https://openalex.org/W2060527543","https://openalex.org/W2065307318","https://openalex.org/W2065956379","https://openalex.org/W2069968649","https://openalex.org/W2076889715","https://openalex.org/W2093531092","https://openalex.org/W2106784406","https://openalex.org/W2107235439","https://openalex.org/W2112133235","https://openalex.org/W2112866067","https://openalex.org/W2116828514","https://openalex.org/W2122457225","https://openalex.org/W2126874760","https://openalex.org/W2127704524","https://openalex.org/W2131678280","https://openalex.org/W2131727319","https://openalex.org/W2136357996","https://openalex.org/W2146478154","https://openalex.org/W2155779547","https://openalex.org/W2163144289","https://openalex.org/W2164521200","https://openalex.org/W2167264906","https://openalex.org/W2776663677","https://openalex.org/W4313333772"],"related_works":["https://openalex.org/W2789706093","https://openalex.org/W2014112474","https://openalex.org/W2165266316","https://openalex.org/W7095751984","https://openalex.org/W2065307318","https://openalex.org/W2009944688","https://openalex.org/W1999195236","https://openalex.org/W2169584514","https://openalex.org/W1993339415","https://openalex.org/W2151826047"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":46}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}