{"id":"https://openalex.org/W1964137248","doi":"https://doi.org/10.3109/10715768509056547","title":"Effect of Liposomal-Encapsulated Superoxide Dismutase on Active Oxygen-Related Human Disorders. A Preliminary Study","display_name":"Effect of Liposomal-Encapsulated Superoxide Dismutase on Active Oxygen-Related Human Disorders. A Preliminary Study","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W1964137248","doi":"https://doi.org/10.3109/10715768509056547","mag":"1964137248","pmid":"https://pubmed.ncbi.nlm.nih.gov/3880279"},"language":"en","primary_location":{"id":"doi:10.3109/10715768509056547","doi":"https://doi.org/10.3109/10715768509056547","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10715768509056547","pdf_url":null,"source":{"id":"https://openalex.org/S4210177992","display_name":"Free Radical Research Communications","issn_l":"8755-0199","issn":["8755-0199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111860667","display_name":"Yukie Niwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukie Niwa","raw_affiliation_strings":["Department of Internal Medicine, Shimane Medical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Shimane Medical University, Japan","institution_ids":["https://openalex.org/I4405285000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111419045","display_name":"Kyoichi Somiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163216","display_name":"Hamamatsu Medical Center","ror":"https://ror.org/05vrdt216","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210163216"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoichi Somiya","raw_affiliation_strings":["Department of Pediatrics, Hamamatsu Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hamamatsu Medical Center, Japan","institution_ids":["https://openalex.org/I4210163216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114241081","display_name":"A. Michael Michelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107423","display_name":"Institut de Biologie Physico-Chimique","ror":"https://ror.org/01na0pb61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107423"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Michael Michelson","raw_affiliation_strings":["Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I4210107423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108511421","display_name":"Krystyna Puget","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107423","display_name":"Institut de Biologie Physico-Chimique","ror":"https://ror.org/01na0pb61","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107423"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Krystyna Puget","raw_affiliation_strings":["Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, 75005, Paris, France","institution_ids":["https://openalex.org/I4210107423"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4124,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.90489914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"2","first_page":"137","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7839999794960022},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/behcet-s-disease","display_name":"Beh\u00e7et's disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/kawasaki-disease","display_name":"Kawasaki disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dermatitis-herpetiformis","display_name":"dermatitis herpetiformis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cement-dermatitis","display_name":"cement dermatitis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiotoxicity","display_name":"chemotherapy-induced cardiotoxicity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8904533386230469},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5327211618423462},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4688483476638794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43051743507385254},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4175903797149658},{"id":"https://openalex.org/C2777712501","wikidata":"https://www.wikidata.org/wiki/Q3704725","display_name":"Defibrotide","level":4,"score":0.4116343855857849},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3642124831676483},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19350388646125793},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000743","descriptor_name":"Anemia, Hemolytic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001528","descriptor_name":"Behcet Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10715768509056547","doi":"https://doi.org/10.3109/10715768509056547","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10715768509056547","pdf_url":null,"source":{"id":"https://openalex.org/S4210177992","display_name":"Free Radical Research Communications","issn_l":"8755-0199","issn":["8755-0199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research Communications","raw_type":"journal-article"},{"id":"pmid:3880279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3880279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1569947394","https://openalex.org/W1571406674","https://openalex.org/W1603656984","https://openalex.org/W1755679601","https://openalex.org/W1828224642","https://openalex.org/W1966377054","https://openalex.org/W1970320176","https://openalex.org/W1975335813","https://openalex.org/W1997913415","https://openalex.org/W2008200472","https://openalex.org/W2010456160","https://openalex.org/W2032348975","https://openalex.org/W2037272057","https://openalex.org/W2054817051","https://openalex.org/W2111426313","https://openalex.org/W2320906887","https://openalex.org/W2324089817","https://openalex.org/W2436168978","https://openalex.org/W2461109863","https://openalex.org/W3135701012","https://openalex.org/W4236886772"],"related_works":["https://openalex.org/W2333221501","https://openalex.org/W3121238325","https://openalex.org/W1490146132","https://openalex.org/W2023674177","https://openalex.org/W2323009766","https://openalex.org/W2350954573","https://openalex.org/W2503252661","https://openalex.org/W2746342737","https://openalex.org/W2316871167","https://openalex.org/W2754929757"],"abstract_inverted_index":{"Liposomal-encapsulated":[0],"superoxide":[1],"dismutase":[2],"was":[3,68,82,143],"clinically":[4],"applied":[5],"to":[6,158,235,245],"patient":[7],"showing":[8],"an":[9],"increase":[10],"in":[11,33,53,56,78,171],"neutrophil":[12],"active":[13,63,111,147],"oxygen":[14],"generation,":[15],"and":[16,28,112,132,150,184,196,205,216,239,242],"those":[17],"with":[18,62,73,155],"diseases":[19,81],"such":[20],"as":[21,220],"severe":[22,104,113,146],"rheumatoid":[23],"arthritis":[24],"(RA),":[25],"Crohn's":[26,124],"disease":[27],"progressive":[29],"systemic":[30],"sclerosis":[31],"(PSS)":[32],"which":[34,227],"presence":[35],"of":[36,59,85,95,109,117,122,128,135,166,174,213,223],"a":[37,50,221],"plasmatic":[38],"clastogenic":[39],"factor":[40],"has":[41,231],"been":[42],"demonstrated.":[43],"Liposomal":[44,225],"SOD":[45,237],"injection":[46],"(2.5":[47],"mg":[48],"twice":[49],"week)":[51],"resulted":[52],"marked":[54],"remission":[55],"12":[57],"out":[58,84,94,108,116,121,127,134,173],"16":[60],"patients":[61,72,149,154,179],"Behcet's":[64],"disease.":[65],"The":[66],"drug":[67,208],"impressively":[69],"effective":[70],"on":[71],"intestinal":[74],"Behcet.":[75],"Remission":[76],"rates":[77],"the":[79,207,211],"other":[80],"7":[83],"8":[86],"mucocutaneous":[87],"lymphnode":[88],"syndrome":[89],"(MCLS,":[90],"Kawasaki":[91],"disease)":[92],"3":[93,115,118,126],"5":[96],"dermatitis":[97],"herpetiformis,":[98],"IgA":[99],"linear":[100],"bullous":[101],"dermatosis":[102],"or":[103],"cement":[105],"dermatitis,":[106],"4":[107,120,123,129],"9":[110],"RA,":[114],"PSS,":[119],"disease,":[125],"colitis":[130],"ulcerosa,":[131],"2":[133,136],"unresponsive":[137],"(hemolytic)":[138],"anemia.":[139],"To":[140],"be":[141],"emphasized":[142],"that":[144],"three":[145],"RA":[148],"two":[151],"terminal-stage":[152],"PSS":[153],"dyspnea":[156],"due":[157],"lung":[159],"fibrosis":[160],"showed":[161],"dramatic":[162],"improvement":[163],"after":[164],"administration":[165],"liposomal":[167],"SOD.":[168],"In":[169],"addition,":[170],"13":[172],"15":[175],"malignant":[176,182],"neo":[177],"plastic":[178],"including":[180,198],"cancer,":[181],"lymphoma":[183],"leucemia":[185],"who":[186],"were":[187],"receiving":[188],"radiotherapy":[189],"(total":[190,201],"dose,":[191],"more":[192],"than":[193],"4000":[194],"rads)":[195],"chemotherapy":[197],"anthracycline":[199],"analogs":[200],"over":[202],"450":[203],"mg/m2)":[204],"bleomycin,":[206],"also":[209],"prevented":[210],"appearance":[212],"myocardiac":[214],"injury":[215],"fibrosis,":[217],"sometimes":[218],"seen":[219],"consequence":[222],"chemotherapy.":[224],"SOD,":[226],"shows":[228],"no":[229],"toxicity,":[230],"various":[232,246],"advantages":[233],"compared":[234],"free":[236],"preparations,":[238],"is":[240],"highly":[241],"broadly":[243],"applicable":[244],"clinical":[247],"disorders.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}