{"id":"https://openalex.org/W1964103753","doi":"https://doi.org/10.1074/jbc.m202301200","title":"Ras Signaling Enhances the Activity of C/EBP\u03b1 to Induce Granulocytic Differentiation by Phosphorylation of Serine 248","display_name":"Ras Signaling Enhances the Activity of C/EBP\u03b1 to Induce Granulocytic Differentiation by Phosphorylation of Serine 248","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W1964103753","doi":"https://doi.org/10.1074/jbc.m202301200","mag":"1964103753","pmid":"https://pubmed.ncbi.nlm.nih.gov/11978795"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m202301200","doi":"https://doi.org/10.1074/jbc.m202301200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202301200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m202301200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064722914","display_name":"Gerhard Behre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gerhard Behre","raw_affiliation_strings":["Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany. gerdbehre@aol.com","Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany. gerdbehre@aol.com","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039005787","display_name":"Sheo Mohan Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sheo M. Singh","raw_affiliation_strings":["Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115588460","display_name":"Huaitian Liu","orcid":"https://orcid.org/0000-0002-7791-1502","observed_orcids":["https://orcid.org/0000-0002-7791-1502"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaitian Liu","raw_affiliation_strings":["Johns Hopkins Oncology Center, Baltimore, Maryland 21287-5001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Oncology Center, Baltimore, Maryland 21287-5001","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046590379","display_name":"Laura T. Bortolin","orcid":"https://orcid.org/0000-0003-4444-6058","observed_orcids":["https://orcid.org/0000-0003-4444-6058"]},"institutions":[{"id":"https://openalex.org/I4210122954","display_name":"MIT Lincoln Laboratory","ror":"https://ror.org/022z6jk58","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210122954","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura T. Bortolin","raw_affiliation_strings":["**Massachusetts Institute of Technology/Lincoln Laboratory, Lexington, Massachusetts 02420-9185"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Massachusetts Institute of Technology/Lincoln Laboratory, Lexington, Massachusetts 02420-9185","institution_ids":["https://openalex.org/I4210122954","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031660112","display_name":"Maximilian Christopeit","orcid":"https://orcid.org/0000-0003-4627-0412","observed_orcids":["https://orcid.org/0000-0003-4627-0412"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Max Christopeit","raw_affiliation_strings":["Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007253657","display_name":"Hanna S. Radomska","orcid":"https://orcid.org/0000-0001-6370-7765","observed_orcids":["https://orcid.org/0000-0001-6370-7765"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanna S. Radomska","raw_affiliation_strings":["Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031734936","display_name":"Janki Rangatia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janki Rangatia","raw_affiliation_strings":["Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108511937","display_name":"Wolfgang Hiddemann","orcid":"https://orcid.org/0000-0003-3634-2558","observed_orcids":["https://orcid.org/0000-0003-3634-2558","https://orcid.org/0000-0001-7208-4117"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Hiddemann","raw_affiliation_strings":["Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, D-81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002253253","display_name":"Alan D. Friedman","orcid":"https://orcid.org/0000-0002-5615-7061","observed_orcids":["https://orcid.org/0000-0002-5615-7061"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan D. Friedman","raw_affiliation_strings":["Johns Hopkins Oncology Center, Baltimore, Maryland 21287-5001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Oncology Center, Baltimore, Maryland 21287-5001","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056687452","display_name":"Daniel Geoffrey Tenen","orcid":"https://orcid.org/0000-0002-6423-3888","observed_orcids":["https://orcid.org/0000-0002-6423-3888"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel G. Tenen","raw_affiliation_strings":["Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5064722914"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I8204097"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.5309,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.93075899,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"277","issue":"29","first_page":"26293","last_page":"26299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.29789999127388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.07880000025033951,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor-receptor","display_name":"granulocyte colony-stimulating factor receptor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.7979999780654907},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7559999823570251},{"id":"https://openalex.org/keywords/myelopoiesis","display_name":"myelopoiesis","score":0.875},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9690544605255127},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6655948162078857},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.6218733191490173},{"id":"https://openalex.org/C149240914","wikidata":"https://www.wikidata.org/wiki/Q907967","display_name":"Ccaat-enhancer-binding proteins","level":5,"score":0.6202386617660522},{"id":"https://openalex.org/C14942488","wikidata":"https://www.wikidata.org/wiki/Q14908143","display_name":"Granulocyte colony-stimulating factor receptor","level":4,"score":0.5950955152511597},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5390948057174683},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5109023451805115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4857947826385498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4713831841945648},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4713142514228821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35653001070022583},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.23141267895698547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21211278438568115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15373310446739197},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.13823440670967102},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.057874858379364014}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016188","descriptor_name":"Receptors, Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022763","descriptor_name":"CCAAT-Enhancer-Binding Protein-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022763","descriptor_name":"CCAAT-Enhancer-Binding Protein-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m202301200","doi":"https://doi.org/10.1074/jbc.m202301200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202301200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11978795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11978795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m202301200","doi":"https://doi.org/10.1074/jbc.m202301200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m202301200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1562829919","display_name":"ROLE OF C/EBPalpha AND MYELOPOIESIS","funder_award_id":"R01HL056745","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G224256104","display_name":null,"funder_award_id":"CA-72009","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2405091563","display_name":null,"funder_award_id":"HL56745","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4104047604","display_name":"INTERACTING FACTORS IN HEMATOPOIESIS AND LEUKEMIA","funder_award_id":"P01CA072009","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W43784428","https://openalex.org/W114905856","https://openalex.org/W179818011","https://openalex.org/W215245711","https://openalex.org/W385171849","https://openalex.org/W1489323849","https://openalex.org/W1502074492","https://openalex.org/W1506350545","https://openalex.org/W1524671781","https://openalex.org/W1528493806","https://openalex.org/W1553385236","https://openalex.org/W1820527096","https://openalex.org/W1835109348","https://openalex.org/W1895834181","https://openalex.org/W1945687446","https://openalex.org/W1964842789","https://openalex.org/W1965942536","https://openalex.org/W1967037408","https://openalex.org/W1970066197","https://openalex.org/W1974612283","https://openalex.org/W1974937526","https://openalex.org/W1986660515","https://openalex.org/W1987598864","https://openalex.org/W1988059168","https://openalex.org/W1994987603","https://openalex.org/W2003886366","https://openalex.org/W2004450968","https://openalex.org/W2005019916","https://openalex.org/W2009379631","https://openalex.org/W2018054628","https://openalex.org/W2019088616","https://openalex.org/W2019937507","https://openalex.org/W2022815760","https://openalex.org/W2036641811","https://openalex.org/W2038912397","https://openalex.org/W2042505694","https://openalex.org/W2043129312","https://openalex.org/W2047626730","https://openalex.org/W2053208432","https://openalex.org/W2054737276","https://openalex.org/W2056465276","https://openalex.org/W2059340669","https://openalex.org/W2064541600","https://openalex.org/W2068728784","https://openalex.org/W2070538981","https://openalex.org/W2074333479","https://openalex.org/W2078459253","https://openalex.org/W2079081366","https://openalex.org/W2085033687","https://openalex.org/W2096757412","https://openalex.org/W2100088478","https://openalex.org/W2106064881","https://openalex.org/W2107258432","https://openalex.org/W2108404291","https://openalex.org/W2109841776","https://openalex.org/W2113086962","https://openalex.org/W2119577005","https://openalex.org/W2123180955","https://openalex.org/W2123480703","https://openalex.org/W2127621383","https://openalex.org/W2127632559","https://openalex.org/W2129011493","https://openalex.org/W2130524213","https://openalex.org/W2131627815","https://openalex.org/W2133353140","https://openalex.org/W2137105120","https://openalex.org/W2138483214","https://openalex.org/W2138492937","https://openalex.org/W2158608327","https://openalex.org/W2160680028","https://openalex.org/W2161743101","https://openalex.org/W2161768644","https://openalex.org/W2164389880","https://openalex.org/W2166788322","https://openalex.org/W2170005346","https://openalex.org/W2172437363","https://openalex.org/W2279275424","https://openalex.org/W2286150378","https://openalex.org/W2299606380","https://openalex.org/W2323808648","https://openalex.org/W2415311436","https://openalex.org/W2416487144","https://openalex.org/W2464733971"],"related_works":["https://openalex.org/W6913070293","https://openalex.org/W7097131821","https://openalex.org/W2162090616","https://openalex.org/W2015198577","https://openalex.org/W2114538465","https://openalex.org/W2152895316","https://openalex.org/W2017468335","https://openalex.org/W2022815760","https://openalex.org/W2054737276","https://openalex.org/W2022188016"],"abstract_inverted_index":{"The":[0,71],"transcription":[1],"factor":[2,31,89],"C/EBP":[3,19,42,58,82,98,105,129,137,148,162,174,202,217,235],"alpha":[4,20,43,59,83,106,130,138,149,163,175,193,203,218,236],"regulates":[5],"early":[6],"steps":[7],"of":[8,17,27,57,81,117,146,160,173,191,201,208,216,234,243],"normal":[9],"granulocyte":[10,29,87],"differentiation":[11,240],"since":[12],"mice":[13],"with":[14],"a":[15,93,118,122,161,177,185,226],"disruption":[16],"the":[18,28,54,79,86,108,114,128,147,157,189,214,232],"gene":[21],"do":[22],"not":[23,68,135,155],"express":[24],"detectable":[25],"levels":[26],"colony-stimulating":[30,88],"receptor":[32,90],"and":[33,65,92,127,133,184],"produce":[34],"no":[35],"neutrophils.":[36],"We":[37],"have":[38],"recently":[39],"shown":[40],"that":[41,75],"function":[44,116,159],"is":[45,60,67,176],"also":[46],"impaired":[47],"in":[48,63,204],"acute":[49],"myeloid":[50],"leukemias.":[51],"However,":[52],"how":[53],"transcriptional":[55],"activity":[56,233],"regulated":[61],"both":[62],"myelopoiesis":[64],"leukemogenesis":[66],"fully":[69],"understood.":[70],"current":[72],"study":[73],"demonstrates":[74],"activated":[76],"Ras":[77,102,141,196,229],"enhances":[78,113,231],"ability":[80,215],"to":[84,166,199,211,219,237],"transactivate":[85],"promoter":[91,95],"minimal":[94],"containing":[96,121],"only":[97],"DNA":[99,124,139],"binding":[100,125],"sites.":[101],"signaling":[103,197,230],"activates":[104],"via":[107],"transactivation":[109,115,131,150,158],"domain":[110,126,132],"because":[111,152],"it":[112,153],"fusion":[119],"protein":[120,178],"Gal4":[123],"does":[134,154],"change":[136],"binding.":[140],"acts":[142],"on":[143],"serine":[144,164,171,209,244],"248":[145,165,172,210],"domain,":[151],"enhance":[156],"alanine":[167,212],"point":[168],"mutant.":[169],"Interestingly,":[170],"kinase":[179],"C":[180],"(PKC)":[181],"consensus":[182],"site,":[183],"PKC":[186],"inhibitor":[187],"blocks":[188],"activation":[190],"C/EB":[192],"by":[194,241],"Ras.":[195],"leads":[198],"phosphorylation":[200,242],"vivo.":[205],"Finally,":[206],"mutation":[207],"obviates":[213],"induce":[220,238],"granulocytic":[221,239],"differentiation.":[222],"These":[223],"data":[224],"suggest":[225],"model":[227],"where":[228],"248.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}