{"id":"https://openalex.org/W1964088769","doi":"https://doi.org/10.1007/s11999-011-2057-x","title":"The John Charnley Award: An Accurate and Sensitive Method to Separate, Display, and Characterize Wear Debris: Part 1: Polyethylene Particles","display_name":"The John Charnley Award: An Accurate and Sensitive Method to Separate, Display, and Characterize Wear Debris: Part 1: Polyethylene Particles","publication_year":2011,"publication_date":"2011-10-13","ids":{"openalex":"https://openalex.org/W1964088769","doi":"https://doi.org/10.1007/s11999-011-2057-x","mag":"1964088769","pmid":"https://pubmed.ncbi.nlm.nih.gov/21997780","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3254734"},"language":"en","primary_location":{"id":"doi:10.1007/s11999-011-2057-x","doi":"https://doi.org/10.1007/s11999-011-2057-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11999-011-2057-x","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics & Related Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1964088769"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3254734","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018539747","display_name":"Fabrizio Billi","orcid":"https://orcid.org/0000-0003-2217-7694","observed_orcids":["https://orcid.org/0000-0003-2217-7694"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabrizio Billi","raw_affiliation_strings":["The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, Los Angeles, CA 90007, USA. fbilli@laoh.ucla.edu","The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","e-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, Los Angeles, CA 90007, USA. fbilli@laoh.ucla.edu","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]},{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]},{"raw_affiliation_string":"e-mail","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018260314","display_name":"Paul D. Benya","orcid":"https://orcid.org/0000-0002-1060-7127","observed_orcids":["https://orcid.org/0000-0002-1060-7127"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Benya","raw_affiliation_strings":["The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075556948","display_name":"Aaron E. Kavanaugh","orcid":"https://orcid.org/0000-0003-1425-7221","observed_orcids":["https://orcid.org/0000-0003-1425-7221"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Kavanaugh","raw_affiliation_strings":["The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Adams","raw_affiliation_strings":["The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073998638","display_name":"Edward Ebramzadeh","orcid":"https://orcid.org/0000-0001-5282-8465","observed_orcids":["https://orcid.org/0000-0001-5282-8465"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Ebramzadeh","raw_affiliation_strings":["The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041590666","display_name":"Harry A. McKellop","orcid":"https://orcid.org/0000-0002-0912-665X","observed_orcids":["https://orcid.org/0000-0002-0912-665X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210116300","display_name":"Orthopaedic Hospital","ror":"https://ror.org/01m2js356","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210116300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry McKellop","raw_affiliation_strings":["The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The J. Vernon Luck Sr., MD, Orthopaedic Research Center at Orthopaedic Hospital, UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine, 90007, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210116300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3148,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86577483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"470","issue":"2","first_page":"329","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12252","display_name":"Mechanical stress and fatigue analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyethylene-wear-particles","display_name":"polyethylene wear particles","score":0.859000027179718},{"id":"https://openalex.org/keywords/hip-arthroplasty","display_name":"total hip arthroplasty","score":0.8429999947547913},{"id":"https://openalex.org/keywords/acetabular-liner","display_name":"acetabular liner","score":0.9330000281333923},{"id":"https://openalex.org/keywords/crosslinked-polyethylene","display_name":"cross-linked polyethylene","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gamma-irradiation-crosslinking","display_name":"gamma irradiation crosslinking","score":0.8790000081062317},{"id":"https://openalex.org/keywords/density-gradient-ultracentrifugation","display_name":"density gradient ultracentrifugation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/enzymatic-protein-digestion","display_name":"enzymatic protein digestion","score":0.828000009059906},{"id":"https://openalex.org/keywords/particle-size-distribution","display_name":"particle size distribution","score":0.9089999794960022},{"id":"https://openalex.org/keywords/particle-morphology","display_name":"particle morphology","score":0.8299999833106995},{"id":"https://openalex.org/keywords/periprosthetic-tissue","display_name":"periprosthetic tissue","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2779751980","wikidata":"https://www.wikidata.org/wiki/Q143429","display_name":"Polyethylene","level":2,"score":0.8103820085525513},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5613077878952026},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.5272416472434998},{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.5232595205307007},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4979126453399658},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.48503392934799194},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.43556058406829834},{"id":"https://openalex.org/C160671074","wikidata":"https://www.wikidata.org/wiki/Q267131","display_name":"Wafer","level":2,"score":0.43362823128700256},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.31843113899230957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3136901259422302},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25988471508026123},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16624468564987183},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.12942099571228027},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001363","descriptor_name":"Awards and Prizes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002499","descriptor_name":"Centrifugation, Density Gradient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002623","descriptor_name":"Chemistry Techniques, Analytical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006622","descriptor_name":"Hip Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011474","descriptor_name":"Prosthesis Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011475","descriptor_name":"Prosthesis Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012828","descriptor_name":"Silicones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020959","descriptor_name":"Polyethylene","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020959","descriptor_name":"Polyethylene","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D020959","descriptor_name":"Polyethylene","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s11999-011-2057-x","doi":"https://doi.org/10.1007/s11999-011-2057-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11999-011-2057-x","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics & Related Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2556626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3254734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21997780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21997780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3254734","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3254734/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Orthop Relat Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2556626","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3254734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W52030373","https://openalex.org/W115367669","https://openalex.org/W206734024","https://openalex.org/W1914858881","https://openalex.org/W1965621427","https://openalex.org/W1968090295","https://openalex.org/W1972157130","https://openalex.org/W1987124721","https://openalex.org/W1993345211","https://openalex.org/W1995466275","https://openalex.org/W2004757362","https://openalex.org/W2005927841","https://openalex.org/W2007238373","https://openalex.org/W2007725429","https://openalex.org/W2007835360","https://openalex.org/W2008912694","https://openalex.org/W2023560397","https://openalex.org/W2030515206","https://openalex.org/W2034714636","https://openalex.org/W2038923557","https://openalex.org/W2043006524","https://openalex.org/W2043701451","https://openalex.org/W2044194503","https://openalex.org/W2049937830","https://openalex.org/W2057782935","https://openalex.org/W2058455922","https://openalex.org/W2060942013","https://openalex.org/W2068562565","https://openalex.org/W2071069138","https://openalex.org/W2071845543","https://openalex.org/W2072150397","https://openalex.org/W2077326211","https://openalex.org/W2078981773","https://openalex.org/W2081048872","https://openalex.org/W2089376561","https://openalex.org/W2100835268","https://openalex.org/W2118161717","https://openalex.org/W2120999308","https://openalex.org/W2122756727","https://openalex.org/W2127193083","https://openalex.org/W2130111797","https://openalex.org/W2134104972","https://openalex.org/W2143916519","https://openalex.org/W2148684923","https://openalex.org/W2165524494","https://openalex.org/W2165894947","https://openalex.org/W2187192051","https://openalex.org/W2407749168","https://openalex.org/W2413187064"],"related_works":["https://openalex.org/W2115119344","https://openalex.org/W2339443948","https://openalex.org/W2078576120","https://openalex.org/W2031575644","https://openalex.org/W2044388898","https://openalex.org/W39993553","https://openalex.org/W2336297263","https://openalex.org/W2033854724","https://openalex.org/W1786491325","https://openalex.org/W2071845543"],"abstract_inverted_index":{"BACKGROUND:":[0],"Numerous":[1],"studies":[2],"indicate":[3],"highly":[4],"crosslinked":[5],"polyethylenes":[6],"reduce":[7],"the":[8,69,72,88,104,110,123,163,171,228,233],"wear":[9,37,45,134,211,217,229],"debris":[10],"volume":[11],"generated":[12],"by":[13,128],"hip":[14],"arthroplasty":[15],"acetabular":[16,141],"liners.":[17],"This,":[18],"in":[19,44,162,214],"turns,":[20],"requires":[21],"new":[22,124,157,187],"methods":[23],"to":[24,83,226],"isolate":[25],"and":[26,47,53,75,86,106,120,130,145,148,167,200,235,237],"characterize":[27],"them.":[28],"QUESTIONS/PURPOSES:":[29],"We":[30],"describe":[31],"a":[32,96,190,223],"method":[33,66,158],"for":[34,48],"extracting":[35],"polyethylene":[36,140,175,210],"particles":[38,74,89,105,132,199,212,234],"from":[39,133],"bovine":[40],"serum":[41],"typically":[42],"used":[43],"tests":[46,135,218],"characterizing":[49,131],"their":[50,77,239],"size,":[51],"distribution,":[52],"morphology.":[54],"METHODS:":[55],"Serum":[56],"proteins":[57],"were":[58,126],"completely":[59],"digested":[60],"using":[61,181],"an":[62],"optimized":[63],"enzymatic":[64],"digestion":[65],"that":[67,176,231],"prevented":[68],"loss":[70,196],"of":[71,103,122,136,139,151,174,192,197,209,219],"smallest":[73],"minimized":[76],"clumping.":[78],"Density-gradient":[79],"ultracentrifugation":[80],"was":[81],"designed":[82],"remove":[84],"contaminants":[85],"recover":[87],"without":[90],"filtration,":[91],"depositing":[92],"them":[93],"directly":[94],"onto":[95],"silicon":[97],"wafer.":[98],"This":[99],"provided":[100],"uniform":[101],"distribution":[102],"high":[107],"contrast":[108],"against":[109],"background,":[111],"facilitating":[112],"accurate,":[113],"automated,":[114],"morphometric":[115],"image":[116],"analysis.":[117],"The":[118,156,186,207],"accuracy":[119],"precision":[121],"protocol":[125,188],"assessed":[127],"recovering":[129],"three":[137,172],"types":[138,173],"cups":[142],"(no":[143],"crosslinking":[144],"5":[146],"Mrads":[147,150],"7.5":[149],"gamma":[152],"irradiation":[153],"crosslinking).":[154],"RESULTS:":[155],"demonstrated":[159],"important":[160],"differences":[161],"particle":[164],"size":[165],"distributions":[166],"morphologic":[168],"parameters":[169],"among":[170,203],"could":[177],"not":[178],"be":[179],"detected":[180],"prior":[182],"isolation":[183],"methods.":[184],"CONCLUSION:":[185],"overcomes":[189],"number":[191],"limitations,":[193],"such":[194],"as":[195],"nanometer-sized":[198],"artifactual":[201],"clumping,":[202],"others.":[204],"CLINICAL":[205],"RELEVANCE:":[206],"analysis":[208],"produced":[213],"joint":[215],"simulator":[216],"prosthetic":[220],"joints":[221],"is":[222],"key":[224],"tool":[225],"identify":[227],"mechanisms":[230],"produce":[232],"predict":[236],"evaluate":[238],"effects":[240],"on":[241],"periprosthetic":[242],"tissues.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}