{"id":"https://openalex.org/W1964086646","doi":"https://doi.org/10.1074/jbc.m009395200","title":"Evaluating the Signal Transduction Mechanism of the Parathyroid Hormone 1 Receptor","display_name":"Evaluating the Signal Transduction Mechanism of the Parathyroid Hormone 1 Receptor","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W1964086646","doi":"https://doi.org/10.1074/jbc.m009395200","mag":"1964086646","pmid":"https://pubmed.ncbi.nlm.nih.gov/11108715"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m009395200","doi":"https://doi.org/10.1074/jbc.m009395200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m009395200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m009395200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110503078","display_name":"Sam R.J. Hoare","orcid":"https://orcid.org/0000-0002-5219-157X","observed_orcids":["https://orcid.org/0000-0002-5219-157X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam R.J. Hoare","raw_affiliation_strings":["Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092, USA","From the \u2021Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"From the \u2021Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092 and the","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015542125","display_name":"Thomas James Gardella","orcid":"https://orcid.org/0000-0002-2163-5772","observed_orcids":["https://orcid.org/0000-0002-2163-5772"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Gardella","raw_affiliation_strings":["\u00a7Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073787062","display_name":"Ted Bj\u00f6rn Usdin","orcid":"https://orcid.org/0000-0003-3813-0049","observed_orcids":["https://orcid.org/0000-0003-3813-0049"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ted B. Usdin","raw_affiliation_strings":["From the \u2021Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092 and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the \u2021Unit on Cell Biology, Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland 20892-4092 and the","institution_ids":["https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073787062"],"corresponding_institution_ids":["https://openalex.org/I4210158500"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.9093,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.91075436,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"276","issue":"11","first_page":"7741","last_page":"7753"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pth1r","display_name":"PTH1R","score":0.9890000224113464},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7269999980926514},{"id":"https://openalex.org/keywords/receptor-conformation","display_name":"receptor conformation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/ligand-binding-site","display_name":"ligand binding sites","score":0.7559999823570251},{"id":"https://openalex.org/keywords/juxtamembrane-domain","display_name":"juxtamembrane domain","score":0.9110000133514404},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.8410000205039978},{"id":"https://openalex.org/keywords/two-site-binding-model","display_name":"two-site model","score":0.6740000247955322},{"id":"https://openalex.org/keywords/gtpgammas-binding","display_name":"GTPgammaS binding","score":0.7400000095367432},{"id":"https://openalex.org/keywords/camp-accumulation","display_name":"cAMP accumulation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/agonist-binding","display_name":"agonist binding","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6059393286705017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5916829109191895},{"id":"https://openalex.org/C168557967","wikidata":"https://www.wikidata.org/wiki/Q24772254","display_name":"Parathyroid hormone receptor","level":5,"score":0.5858709812164307},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5731677412986755},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5597453117370605},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5578907132148743},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5423375964164734},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5313523411750793},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4435173273086548},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.4318923354148865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22070342302322388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19808250665664673},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.1872541308403015},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1462712585926056},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018016","descriptor_name":"Receptors, Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018016","descriptor_name":"Receptors, Parathyroid Hormone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044168","descriptor_name":"Receptor, Parathyroid Hormone, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m009395200","doi":"https://doi.org/10.1074/jbc.m009395200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m009395200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11108715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11108715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m009395200","doi":"https://doi.org/10.1074/jbc.m009395200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m009395200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1974953","https://openalex.org/W1529983368","https://openalex.org/W1565777522","https://openalex.org/W1578229516","https://openalex.org/W1592400272","https://openalex.org/W1965963242","https://openalex.org/W1975100360","https://openalex.org/W1975214384","https://openalex.org/W1976883194","https://openalex.org/W1984986047","https://openalex.org/W1987725877","https://openalex.org/W1988220418","https://openalex.org/W1993787286","https://openalex.org/W1996308425","https://openalex.org/W2006950202","https://openalex.org/W2011417521","https://openalex.org/W2015450937","https://openalex.org/W2018771359","https://openalex.org/W2022630248","https://openalex.org/W2023470266","https://openalex.org/W2025920162","https://openalex.org/W2034175262","https://openalex.org/W2044412575","https://openalex.org/W2045063227","https://openalex.org/W2047309564","https://openalex.org/W2047687741","https://openalex.org/W2048260251","https://openalex.org/W2052973557","https://openalex.org/W2062778364","https://openalex.org/W2074631079","https://openalex.org/W2076513151","https://openalex.org/W2080875376","https://openalex.org/W2082512487","https://openalex.org/W2084308139","https://openalex.org/W2084654327","https://openalex.org/W2085285924","https://openalex.org/W2102179607","https://openalex.org/W2120001912","https://openalex.org/W2127808815","https://openalex.org/W2129863622","https://openalex.org/W2134599993","https://openalex.org/W2138848782","https://openalex.org/W2139129258","https://openalex.org/W2146799127","https://openalex.org/W2148598721","https://openalex.org/W2148639124","https://openalex.org/W2158066978","https://openalex.org/W2158089652","https://openalex.org/W2158648950","https://openalex.org/W2158992629","https://openalex.org/W2168167878","https://openalex.org/W2170174733","https://openalex.org/W2266367605","https://openalex.org/W2267139588","https://openalex.org/W2401100890","https://openalex.org/W3007331336","https://openalex.org/W3120446503","https://openalex.org/W4231134694","https://openalex.org/W4252443437"],"related_works":["https://openalex.org/W2078390858","https://openalex.org/W2148639124","https://openalex.org/W2102109053","https://openalex.org/W2041050634","https://openalex.org/W2141777375","https://openalex.org/W1968710675","https://openalex.org/W2144154207","https://openalex.org/W2044873849","https://openalex.org/W2017075573","https://openalex.org/W4253540274"],"abstract_inverted_index":{"Ligand":[0],"binding":[1,59,68,92,109,136,153,200,224,241,270,280],"to":[2,102,115,118,137,154,174,181,189,201,230,237,303],"the":[3,14,18,22,26,31,35,38,42,51,66,73,103,119,130,248,259,268,300],"PTH1":[4,79],"receptor":[5,27,43,55,61,80,249,295,318],"is":[6,164,251,265],"described":[7],"by":[8,87,141,158,267],"a":[9,168,220,289,313],"\"two-site\"":[10],"model,":[11],"in":[12,57],"which":[13,99],"C-terminal":[15],"portion":[16],"of":[17,25,34,41,54,89,110,132,143,160,217,222,271,281,293,317],"ligand":[19,36,58,67,135],"interacts":[20],"with":[21,145,178],"N-terminal":[23,32],"domain":[24,40],"(N":[28],"interaction),":[29],"and":[30,60,76,96,112,152,205,226,273,283,308,311],"region":[33],"binds":[37,100,172],"juxtamembrane":[39],"(J":[44],"interaction).":[45],"Previous":[46],"studies":[47],"have":[48],"not":[49],"considered":[50],"dynamic":[52],"nature":[53],"conformation":[56,250,264,292,319],"activation.":[62],"In":[63],"this":[64,294],"study":[65],"mechanism":[69],"was":[70,85,139,156,195,219,235,242],"compared":[71],"for":[72,94,197,209,213,315],"G-protein-coupled":[74],"(RG)":[75],"uncoupled":[77],"(R)":[78],"conformations.":[81],"The":[82,192,232,297],"two-site":[83,301],"model":[84,165,302,314],"confirmed":[86],"demonstration":[88],"spatially":[90],"distinct":[91],"sites":[93],"PTH(3-34)":[95,240],"PTH(1-14):":[97],"PTH(1-14),":[98],"predominantly":[101,117],"J":[104,193],"domain,":[105,121],"only":[106,122],"partially":[107,123],"inhibited":[108,124],"125I-PTH(3-34);":[111],"PTH(3-34),":[113],"shown":[114],"bind":[116],"N":[120,233],"PTH(1-14)-stimulated":[125],"cAMP":[126],"accumulation.":[127],"To":[128],"assess":[129],"effect":[131],"R-G":[133,238],"coupling,":[134],"R":[138,260,307],"measured":[140,157],"displacement":[142,159],"125I-PTH(3-34)":[144,282],"30":[146],"microM":[147],"guanosine":[148],"5'-3-O-(thio)triphosphate":[149],"(GTPgammaS)":[150],"present,":[151],"RG":[155,182,255,276,309],"125I-[MAP]PTHrP(1-36)":[161],"(where":[162],"MAP":[163],"amphipathic":[166],"peptide),":[167],"new":[169],"radioligand":[170],"that":[171],"selectively":[173,229],"RG.":[175,231],"Agonists":[176],"bound":[177,187,228,286],"higher":[179],"affinity":[180,212],"than":[183,256],"R,":[184],"whereas":[185],"antagonists":[186],"similarly":[188],"these":[190,321],"states.":[191,322],"interaction":[194,234],"responsible":[196],"enhanced":[198],"agonist":[199,284],"RG:":[202],"residues":[203],"1":[204],"2":[206],"were":[207],"required":[208],"increased":[210],"PTH(1-34)":[211],"RG;":[214],"residue":[215],"5":[216],"MAP-PTHrP(1-36)":[218],"determinant":[221],"R/RG":[223],"selectivity,":[225],"PTH(1-14)":[227,272,277],"insensitive":[236],"coupling;":[239],"GTPgammaS-insensitive.":[243],"Finally,":[244],"several":[245],"observations":[246],"suggest":[247,312],"more":[252,290],"\"closed\"":[253],"at":[254],"R.":[257],"At":[258,275],"state,":[261],"an":[262],"open":[263],"suggested":[266],"simultaneous":[269],"PTH(3-34).":[274],"better":[278],"occluded":[279],"ligands":[285],"pseudo-irreversibly,":[287],"suggesting":[288],"closed":[291],"state.":[296],"results":[298],"extend":[299],"take":[304],"into":[305],"account":[306],"conformations":[310],"differences":[316],"between":[320]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}