{"id":"https://openalex.org/W1964044673","doi":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","title":"Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium","display_name":"Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium","publication_year":1984,"publication_date":"1984-12-01","ids":{"openalex":"https://openalex.org/W1964044673","doi":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","mag":"1964044673","pmid":"https://pubmed.ncbi.nlm.nih.gov/6093980"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","doi":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819841201%2954%3A11%3C2367%3A%3AAID-CNCR2820541111%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819841201%2954%3A11%3C2367%3A%3AAID-CNCR2820541111%3E3.0.CO%3B2-F","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111564601","display_name":"Toshimitsu Konno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimitsu Konno","raw_affiliation_strings":["Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112020437","display_name":"Hiroshi Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Maeda","raw_affiliation_strings":["Department of Microbiology, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088808346","display_name":"Ken Iwai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Iwai","raw_affiliation_strings":["Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shojiro Maki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shojiro Maki","raw_affiliation_strings":["Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112074757","display_name":"Seiki Tashiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiki Tashiro","raw_affiliation_strings":["Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067334921","display_name":"M Uchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsukuni Uchida","raw_affiliation_strings":["Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100922660","display_name":"Yoshimasa Miyauchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Miyauchi","raw_affiliation_strings":["Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112020437"],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":7.2182,"has_fulltext":false,"cited_by_count":232,"citation_normalized_percentile":{"value":0.96690307,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"54","issue":"11","first_page":"2367","last_page":"2374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.33250001072883606,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.33250001072883606,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.3312999904155731,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.10760000348091125,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neocarzinostatin","display_name":"neocarzinostatin","score":0.800000011920929},{"id":"https://openalex.org/keywords/smancs","display_name":"SMANCS","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lipiodol","display_name":"lipiodol","score":0.8270000219345093},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6480000019073486},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7070000171661377},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.640999972820282},{"id":"https://openalex.org/keywords/gallbladder-cancer","display_name":"gallbladder cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiopharmaceutical-therapy","display_name":"radiopharmaceutical therapy","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2778448856","wikidata":"https://www.wikidata.org/wiki/Q4205889","display_name":"Lipiodol","level":3,"score":0.9449409246444702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8761568069458008},{"id":"https://openalex.org/C2779786684","wikidata":"https://www.wikidata.org/wiki/Q906156","display_name":"Contrast medium","level":2,"score":0.6882425546646118},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5552185773849487},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5353162288665771},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4389486610889435},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3812998831272125},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3623361587524414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35649216175079346},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.355593740940094},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3008001446723938},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.28516197204589844}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007459","descriptor_name":"Iodized Oil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008299","descriptor_name":"Maleic Anhydrides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009353","descriptor_name":"Zinostatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009353","descriptor_name":"Zinostatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011137","descriptor_name":"Polystyrenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","doi":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819841201%2954%3A11%3C2367%3A%3AAID-CNCR2820541111%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:6093980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6093980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","doi":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19841201)54:11<2367::aid-cncr2820541111>3.0.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819841201%2954%3A11%3C2367%3A%3AAID-CNCR2820541111%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1964044673.pdf"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W278809653","https://openalex.org/W398784334","https://openalex.org/W562363690","https://openalex.org/W985660402","https://openalex.org/W1480224455","https://openalex.org/W1899397722","https://openalex.org/W1967543010","https://openalex.org/W1986421985","https://openalex.org/W2003956183","https://openalex.org/W2007747310","https://openalex.org/W2012636494","https://openalex.org/W2028211453","https://openalex.org/W2049348498","https://openalex.org/W2062594120","https://openalex.org/W2121491850","https://openalex.org/W2122590547","https://openalex.org/W2130554508","https://openalex.org/W2162207799","https://openalex.org/W2409649606","https://openalex.org/W2437725703","https://openalex.org/W2469307740","https://openalex.org/W4244122029","https://openalex.org/W4244682118"],"related_works":["https://openalex.org/W1899397722","https://openalex.org/W2041377837","https://openalex.org/W2461810341","https://openalex.org/W2081131676","https://openalex.org/W1982171226","https://openalex.org/W2469323193","https://openalex.org/W2007109089","https://openalex.org/W2012636494","https://openalex.org/W2589515938","https://openalex.org/W157582816"],"abstract_inverted_index":{"Twenty-four":[0],"patients":[1],"with":[2,20,62],"various":[3],"solid":[4],"tumors":[5],"including":[6],"metastatic":[7],"liver":[8],"cancer":[9,11],"and":[10,16,40,73,116,126,154,182],"of":[12,53,60,80,99,124,146,156],"the":[13,44,63,67,81,93,100,122,142,171],"lung,":[14,174],"gallbladder,":[15],"pancreas":[17],"were":[18,178],"treated":[19],"a":[21,35,71,87,132],"lipophilic":[22],"macromolecular":[23],"drug,":[24],"copoly(styrene-maleic":[25],"acid)":[26],"conjugated":[27],"neocarzinostatin":[28],"(SMANCS).":[29],"The":[30,51],"drug":[31,65],"was":[32,138],"dissolved":[33],"in":[34,66],"lipid":[36],"contrast":[37],"medium":[38],"Lipiodol":[39,61,125,147],"administered":[41],"by":[42,103],"catheterizing":[43],"respective":[45],"feeding":[46],"arteries":[47],"under":[48],"x-ray":[49,84,104],"monitoring.":[50],"advantages":[52],"this":[54],"therapy":[55],"include:":[56],"(1)":[57],"selective":[58],"deposition":[59],"anti-cancer":[64,75],"target":[68],"tumor,":[69],"(2)":[70],"pronounced":[72],"long-lasting":[74],"effect,":[76],"(3)":[77],"enhanced":[78],"visualization":[79],"tumor":[82],"on":[83],"examinations":[85],"for":[86,131],"prolonged":[88],"period":[89],"which":[90],"also":[91],"facilitated":[92],"long-term":[94],"follow-up,":[95],"(4)":[96],"semiquantitative":[97],"evaluation":[98],"dosage":[101],"regimen":[102],"examination":[105],"before":[106],"further":[107],"administration,":[108],"(5)":[109],"general":[110,183],"applicability":[111],"due":[112],"to":[113,166],"procedural":[114],"simplicity,":[115],"(6)":[117],"little":[118],"side":[119],"effect.":[120],"Since":[121],"amount":[123],"SMANCS":[127,157],"used":[128],"per":[129],"administration":[130],"patient":[133],"(1.0-5.0":[134],"ml;":[135],"1.0-5.0":[136],"mg)":[137],"far":[139],"less":[140],"than":[141],"anticipated":[143],"toxicity":[144],"(LD50":[145],"=":[148,158],"95":[149],"ml/60":[150],"kg,":[151],"dog,":[152],"intravenously;":[153],"that":[155],"3.4":[159],"mg/kg,":[160],"mouse,":[161],"IV),":[162],"no":[163],"deleterious":[164],"effects":[165],"such":[167],"critical":[168],"organs":[169],"as":[170],"brain,":[172],"heart,":[173],"liver,":[175],"or":[176],"kidneys":[177],"observed":[179],"upon":[180],"radiologic":[181],"clinical":[184],"examination.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
