{"id":"https://openalex.org/W1964032793","doi":"https://doi.org/10.4061/2010/604792","title":"Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease","display_name":"Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1964032793","doi":"https://doi.org/10.4061/2010/604792","mag":"1964032793","pmid":"https://pubmed.ncbi.nlm.nih.gov/21151659","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2997345"},"language":"en","primary_location":{"id":"doi:10.4061/2010/604792","doi":"https://doi.org/10.4061/2010/604792","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2010/604792","pdf_url":"https://downloads.hindawi.com/journals/ijad/2010/604792.pdf","source":{"id":"https://openalex.org/S147542015","display_name":"International Journal of Alzheimer s Disease","issn_l":"2090-0252","issn":["2090-0252","2090-8024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ijad/2010/604792.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091278252","display_name":"Wayne Chadwick","orcid":"https://orcid.org/0000-0003-1465-8180","observed_orcids":["https://orcid.org/0000-0003-1465-8180"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Chadwick","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078065036","display_name":"Randall Brenneman","orcid":"https://orcid.org/0000-0001-6167-1746","observed_orcids":["https://orcid.org/0000-0001-6167-1746"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall Brenneman","raw_affiliation_strings":["Miller School of Medicine, University of Miami, Miami, FL 33124, USA","Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miller School of Medicine, University of Miami, Miami, FL 33124, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061101747","display_name":"Bronwen Martin","orcid":"https://orcid.org/0000-0002-9185-6925","observed_orcids":["https://orcid.org/0000-0002-9185-6925"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bronwen Martin","raw_affiliation_strings":["Metabolism Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033862949","display_name":"Stuart R. Maudsley","orcid":"https://orcid.org/0000-0002-1868-184X","observed_orcids":["https://orcid.org/0000-0002-1868-184X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart Maudsley","raw_affiliation_strings":["Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033862949"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":820,"currency":"USD","value_usd":820},"apc_paid":{"value":820,"currency":"USD","value_usd":820},"fwci":4.5459,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.94322549,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2010","issue":null,"first_page":"1","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.875},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/3xtg-ad-mice","display_name":"3xTg-AD mice","score":0.9539999961853027},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.8410000205039978},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.8256626129150391},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5437766909599304},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.46086227893829346},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4439544677734375},{"id":"https://openalex.org/C9132879","wikidata":"https://www.wikidata.org/wiki/Q17100313","display_name":"Raft","level":4,"score":0.432211309671402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4244327247142792},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4226633310317993},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38856321573257446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36542415618896484},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34587275981903076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3392617702484131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22246697545051575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12107479572296143},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0884028971195221},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4061/2010/604792","doi":"https://doi.org/10.4061/2010/604792","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2010/604792","pdf_url":"https://downloads.hindawi.com/journals/ijad/2010/604792.pdf","source":{"id":"https://openalex.org/S147542015","display_name":"International Journal of Alzheimer s Disease","issn_l":"2090-0252","issn":["2090-0252","2090-8024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2997345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2997345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Alzheimers Dis","raw_type":"Text"},{"id":"pmid:21151659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21151659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of Alzheimer's disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:45aced8fb1ba4a4eb1970ae8a814adc5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/45aced8fb1ba4a4eb1970ae8a814adc5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Alzheimer's Disease, Vol 2010 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4061/2010/604792","doi":"https://doi.org/10.4061/2010/604792","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2010/604792","pdf_url":"https://downloads.hindawi.com/journals/ijad/2010/604792.pdf","source":{"id":"https://openalex.org/S147542015","display_name":"International Journal of Alzheimer s Disease","issn_l":"2090-0252","issn":["2090-0252","2090-8024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Alzheimer's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G773668523","display_name":"Oxidative stresses and complex proteomic responses to them","funder_award_id":"ZIAAG000325","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964032793.pdf","grobid_xml":"https://content.openalex.org/works/W1964032793.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W147969435","https://openalex.org/W1482580692","https://openalex.org/W1967464880","https://openalex.org/W1968051733","https://openalex.org/W1980905876","https://openalex.org/W1987082785","https://openalex.org/W1989771766","https://openalex.org/W1994521227","https://openalex.org/W2000276002","https://openalex.org/W2000303677","https://openalex.org/W2004251605","https://openalex.org/W2004791695","https://openalex.org/W2016849092","https://openalex.org/W2019168768","https://openalex.org/W2021181758","https://openalex.org/W2022576341","https://openalex.org/W2023301418","https://openalex.org/W2024987661","https://openalex.org/W2025888688","https://openalex.org/W2034968148","https://openalex.org/W2037396758","https://openalex.org/W2050068554","https://openalex.org/W2053116734","https://openalex.org/W2053923112","https://openalex.org/W2058930537","https://openalex.org/W2068011527","https://openalex.org/W2070596032","https://openalex.org/W2071804866","https://openalex.org/W2074085543","https://openalex.org/W2082075183","https://openalex.org/W2094783617","https://openalex.org/W2096410114","https://openalex.org/W2097646688","https://openalex.org/W2101187328","https://openalex.org/W2109666614","https://openalex.org/W2114027579","https://openalex.org/W2114092053","https://openalex.org/W2116991971","https://openalex.org/W2119297140","https://openalex.org/W2132682806","https://openalex.org/W2134970813","https://openalex.org/W2136558879","https://openalex.org/W2137082708","https://openalex.org/W2140668393","https://openalex.org/W2156635287"],"related_works":["https://openalex.org/W7100169507","https://openalex.org/W4223919325","https://openalex.org/W2518781882","https://openalex.org/W4380880314","https://openalex.org/W3216461458","https://openalex.org/W2118265926","https://openalex.org/W1979158053","https://openalex.org/W1980905876","https://openalex.org/W3213059900","https://openalex.org/W3214026946"],"abstract_inverted_index":{"Various":[0],"animal":[1],"models":[2],"of":[3,14,22,29,36,59,61,69,72,94,114,123],"Alzheimer's":[4],"disease":[5],"(AD)":[6],"have":[7,99],"been":[8],"created":[9],"to":[10,41,108],"assist":[11],"our":[12],"appreciation":[13],"AD":[15],"pathophysiology,":[16],"as":[17,19,86],"well":[18],"aid":[20],"development":[21,35],"novel":[23],"therapeutic":[24],"strategies.":[25],"Despite":[26],"the":[27,34,70,111,119],"discovery":[28],"mutated":[30],"proteins":[31,45,75,117,137],"that":[32,128],"predict":[33],"AD,":[37],"there":[38,129],"are":[39,54,76,130],"likely":[40],"be":[42],"many":[43],"other":[44],"also":[46],"involved":[47],"in":[48,81,118,133,138],"this":[49],"disorder.":[50],"Complex":[51],"physiological":[52],"processes":[53],"mediated":[55],"by":[56],"coherent":[57,92],"interactions":[58,113],"clusters":[60],"functionally":[62],"related":[63],"proteins.":[64,97],"Synaptic":[65,74],"dysfunction":[66],"is":[67],"one":[68],"hallmarks":[71],"AD.":[73,124],"organized":[77],"into":[78],"multiprotein":[79],"complexes":[80],"high-density":[82],"membrane":[83],"structures,":[84],"known":[85],"lipid":[87,140],"rafts.":[88],"These":[89],"microdomains":[90],"enable":[91],"clustering":[93],"synergistic":[95],"signaling":[96,136],"We":[98],"used":[100],"mass":[101],"analytical":[102],"techniques":[103],"and":[104],"multiple":[105],"bioinformatic":[106],"approaches":[107],"better":[109],"appreciate":[110],"intricate":[112],"these":[115],"multifunctional":[116],"3xTgAD":[120,144],"murine":[121],"model":[122],"Our":[125],"results":[126],"show":[127],"significant":[131],"alterations":[132],"numerous":[134],"receptor/cell":[135],"cortical":[139],"rafts":[141],"isolated":[142],"from":[143],"mice.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
