{"id":"https://openalex.org/W1964016236","doi":"https://doi.org/10.1111/j.1540-8167.1998.tb01837.x","title":"Hybrid Pharmacologic and Ablative Therapy: A Novel and Effective Approach for the Management of Atrial Fibrillation","display_name":"Hybrid Pharmacologic and Ablative Therapy: A Novel and Effective Approach for the Management of Atrial Fibrillation","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1964016236","doi":"https://doi.org/10.1111/j.1540-8167.1998.tb01837.x","mag":"1964016236","pmid":"https://pubmed.ncbi.nlm.nih.gov/9607453"},"language":"en","primary_location":{"id":"doi:10.1111/j.1540-8167.1998.tb01837.x","doi":"https://doi.org/10.1111/j.1540-8167.1998.tb01837.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8167.1998.tb01837.x","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016673974","display_name":"David Tsu-Chau Huang","orcid":"https://orcid.org/0000-0002-9165-7643","observed_orcids":["https://orcid.org/0000-0002-9165-7643"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID T. HUANG","raw_affiliation_strings":["Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111718111","display_name":"Kevin M. Monahan","orcid":"https://orcid.org/0000-0001-7483-2238","observed_orcids":["https://orcid.org/0000-0001-7483-2238"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KEVIN M. MONAHAN","raw_affiliation_strings":["From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012332896","display_name":"PETER J. ZIMETBAUM","orcid":"https://orcid.org/0000-0002-7958-7558","observed_orcids":["https://orcid.org/0000-0002-7958-7558"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PETER ZIMETBAUM","raw_affiliation_strings":["From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109072509","display_name":"PANOGIOTIS PAPAGEORGIOU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PANOGIOTIS PAPAGEORGIOU","raw_affiliation_strings":["From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035255844","display_name":"L MEpstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAURENCE MEPSTEIN","raw_affiliation_strings":["From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049784547","display_name":"Mark E. Josephson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"MARK E. JOSEPHSON","raw_affiliation_strings":["From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Harvard-Thorndike Institute of Electrophysiology, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049784547"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":9.0766,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.98219137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"462","last_page":"469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.996999979019165},{"id":"https://openalex.org/keywords/atrial-flutter","display_name":"atrial flutter","score":0.9509999752044678},{"id":"https://openalex.org/keywords/catheter-ablation","display_name":"catheter ablation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.9580000042915344},{"id":"https://openalex.org/keywords/maintenance-of-sinus-rhythm","display_name":"sinus rhythm maintenance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/isthmus-dependent-atrial-flutter","display_name":"isthmus-dependent atrial flutter","score":0.828000009059906},{"id":"https://openalex.org/keywords/atrial-arrhythmia-recurrence","display_name":"atrial arrhythmia recurrence","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9692721366882324},{"id":"https://openalex.org/C19617505","wikidata":"https://www.wikidata.org/wiki/Q156986","display_name":"Ablative case","level":3,"score":0.8101726770401001},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7773466110229492},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5268403887748718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44478166103363037},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41894158720970154},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.10413381457328796}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001282","descriptor_name":"Atrial Flutter","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001282","descriptor_name":"Atrial Flutter","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001282","descriptor_name":"Atrial Flutter","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005424","descriptor_name":"Flecainide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011405","descriptor_name":"Propafenone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011802","descriptor_name":"Quinidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1540-8167.1998.tb01837.x","doi":"https://doi.org/10.1111/j.1540-8167.1998.tb01837.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8167.1998.tb01837.x","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},{"id":"pmid:9607453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9607453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular electrophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W148307300","https://openalex.org/W1968701392","https://openalex.org/W1976950060","https://openalex.org/W1988093110","https://openalex.org/W1988808111","https://openalex.org/W1993436016","https://openalex.org/W2001317681","https://openalex.org/W2004317402","https://openalex.org/W2024604811","https://openalex.org/W2036816448","https://openalex.org/W2041030896","https://openalex.org/W2042898056","https://openalex.org/W2049625706","https://openalex.org/W2065880668","https://openalex.org/W2066941747","https://openalex.org/W2117176106","https://openalex.org/W2141291360","https://openalex.org/W2270507542","https://openalex.org/W2314364287","https://openalex.org/W2341753595","https://openalex.org/W4210768801","https://openalex.org/W4240865150"],"related_works":["https://openalex.org/W2986427024","https://openalex.org/W207406092","https://openalex.org/W2040907740","https://openalex.org/W2182858041","https://openalex.org/W300902243","https://openalex.org/W2048929587","https://openalex.org/W2418857154","https://openalex.org/W2025907633","https://openalex.org/W1984529213","https://openalex.org/W2068508028"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Maintenance":[1],"of":[2,48,56,124,138,154,184,199,212,221],"sinus":[3,178,225],"rhythm":[4,179],"in":[5,44,53,91,98,177],"patients":[6,49,65,93,107,129,141,165,195],"with":[7,16,72,130,142],"recurrent":[8],"atrial":[9,57,73,79,89,96,111,132,155,200,203],"fibrillation":[10,74,201],"is":[11,215],"often":[12],"difficult":[13],"to":[14,32,77,191,202],"achieve":[15],"pharmacologic":[17,39,213],"therapy.":[18],"Complex":[19],"catheter":[20],"ablative":[21,42],"procedures":[22],"are":[23],"being":[24],"developed,":[25],"but":[26],"efficacy":[27],"and":[28,40,94,102,113,162,170,210,218,223],"safety":[29],"issues":[30],"remain":[31,176],"be":[33],"clarified.":[34],"We":[35,62],"hypothesized":[36],"that":[37],"combined":[38],"simple":[41],"therapies":[43],"a":[45,181,216],"targeted":[46],"subset":[47],"will":[50],"improve":[51],"success":[52],"the":[54,114,122,139],"treatment":[55],"fibrillation.":[58],"METHODS":[59],"AND":[60],"RESULTS:":[61],"identified":[63],"13":[64],"(mean":[66],"age":[67],"61.5":[68],"+/-":[69,186],"16.2":[70],"years)":[71],"who":[75,166,196],"converted":[76],"electrocardiographic":[78],"flutter":[80,90,97,133,204],"during":[81,205],"antiarrhythmic":[82,173,206],"drug":[83,207],"treatment.":[84],"Surface":[85],"ECG":[86],"suggested":[87],"\"typical\"":[88],"11":[92],"\"atypical\"":[95],"2.":[99],"Intracardiac":[100],"mapping":[101],"entrainment":[103],"studies":[104],"revealed":[105],"9":[106,128],"had":[108,117,146],"counterclockwise":[109],"isthmus-dependent":[110],"flutter,":[112],"remaining":[115],"4":[116,140],"complex":[118,143],"activation":[119,144],"patterns,":[120],"suggesting":[121],"presence":[123],"multiple":[125],"wavefronts.":[126],"All":[127],"typical":[131],"underwent":[134,167],"successful":[135,147,168],"ablation.":[136,148],"None":[137],"patterns":[145],"Patients":[149],"were":[150],"followed":[151],"for":[152],"recurrences":[153],"arrhythmias":[156],"via":[157],"clinic":[158],"visits,":[159],"record":[160],"review,":[161],"interviews.":[163],"In":[164,194],"ablation":[169,209],"continued":[171],"on":[172],"drugs,":[174],"88.9%":[175],"after":[180],"mean":[182],"follow-up":[183],"14.3":[185],"6.9":[187],"months":[188],"(range":[189],"1":[190],"28).":[192],"CONCLUSION:":[193],"experience":[197],"conversion":[198],"treatment,":[208],"continuation":[211],"therapy":[214],"safe":[217],"effective":[219],"means":[220],"achieving":[222],"maintaining":[224],"rhythm.":[226]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}