{"id":"https://openalex.org/W1963996264","doi":"https://doi.org/10.3892/etm.2013.1265","title":"Rosuvastatin suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation and migration via the MAPK signaling pathway","display_name":"Rosuvastatin suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation and migration via the MAPK signaling pathway","publication_year":2013,"publication_date":"2013-08-20","ids":{"openalex":"https://openalex.org/W1963996264","doi":"https://doi.org/10.3892/etm.2013.1265","mag":"1963996264","pmid":"https://pubmed.ncbi.nlm.nih.gov/24137286","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797300"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2013.1265","doi":"https://doi.org/10.3892/etm.2013.1265","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2013.1265","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2013.1265/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/etm.2013.1265/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031663817","display_name":"Jianting Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIANTING GAN","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435501","display_name":"Ping Li","orcid":"https://orcid.org/0000-0002-2356-0962","observed_orcids":["https://orcid.org/0000-0002-2356-0962","https://orcid.org/0009-0006-6792-2706","https://orcid.org/0000-0002-9386-2181"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"PING LI","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101581152","display_name":"Zhengdong Wang","orcid":"https://orcid.org/0000-0002-2509-597X","observed_orcids":["https://orcid.org/0000-0002-2509-597X"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHENGDONG WANG","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326399","display_name":"Jian Chen","orcid":"https://orcid.org/0000-0001-5230-7141","observed_orcids":["https://orcid.org/0000-0001-5230-7141"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIAN CHEN","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020003300","display_name":"Xiangwen Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIANGWEN LIANG","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347754","display_name":"Ming Liu","orcid":"https://orcid.org/0000-0001-9630-2617","observed_orcids":["https://orcid.org/0000-0001-9630-2617"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MING LIU","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006836216","display_name":"Wenchao Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WENCHAO XIE","raw_affiliation_strings":["Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Sixth Affiliated Hospital of Guangxi Medical University, Yulin, Guangxi 537000, P.R. China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110689708","display_name":"Rui\u2010Xing Yin","orcid":"https://orcid.org/0000-0001-7883-4310","observed_orcids":["https://orcid.org/0000-0001-7883-4310"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RUIXING YIN","raw_affiliation_strings":["Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025528013","display_name":"Feng Huang","orcid":"https://orcid.org/0000-0003-1459-5394","observed_orcids":["https://orcid.org/0000-0003-1459-5394"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FENG HUANG","raw_affiliation_strings":["Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China","institution_ids":["https://openalex.org/I4210126060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5806,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.80952058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"899","last_page":"903"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.30709999799728394,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.30709999799728394,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.27320000529289246,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.15299999713897705,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":1.0},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.9620000123977661},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":1.0},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9869999885559082},{"id":"https://openalex.org/keywords/smooth-muscle-cell-dedifferentiation","display_name":"smooth muscle cell dedifferentiation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/restenosis","display_name":"restenosis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2780499067","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin","level":2,"score":0.870276927947998},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6443029046058655},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5190380215644836},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.4786616265773773},{"id":"https://openalex.org/C2908737378","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin Calcium","level":3,"score":0.44488200545310974},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4445548951625824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4315975308418274},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4266631007194519},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4123859405517578},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38835635781288147},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3476729393005371},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.34688693284988403},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34575194120407104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31696218252182007},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31601792573928833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30471569299697876},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.29092323780059814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13528227806091309},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/etm.2013.1265","doi":"https://doi.org/10.3892/etm.2013.1265","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2013.1265","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2013.1265/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2790397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797300","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24137286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24137286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3797300","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3797300/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/etm.2013.1265","doi":"https://doi.org/10.3892/etm.2013.1265","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2013.1265","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2013.1265/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327278","display_name":"Science and Technology Department of Guangxi Zhuang Autonomous","ror":"https://ror.org/00dhpdx54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963996264.pdf","grobid_xml":"https://content.openalex.org/works/W1963996264.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W102711020","https://openalex.org/W1906844194","https://openalex.org/W1974401889","https://openalex.org/W1974766220","https://openalex.org/W1975696067","https://openalex.org/W1976649309","https://openalex.org/W2003704284","https://openalex.org/W2004016151","https://openalex.org/W2005328257","https://openalex.org/W2025295794","https://openalex.org/W2049010780","https://openalex.org/W2054336520","https://openalex.org/W2058142370","https://openalex.org/W2064042440","https://openalex.org/W2066565780","https://openalex.org/W2083446822","https://openalex.org/W2092483901","https://openalex.org/W2092795012","https://openalex.org/W2115527850","https://openalex.org/W2118590850","https://openalex.org/W2143640595","https://openalex.org/W2146917818","https://openalex.org/W2152694368","https://openalex.org/W2157483701","https://openalex.org/W2157553988","https://openalex.org/W2464537526","https://openalex.org/W4236792589"],"related_works":["https://openalex.org/W2374651219","https://openalex.org/W3154044400","https://openalex.org/W4404341994","https://openalex.org/W7096239609","https://openalex.org/W2767208102","https://openalex.org/W2006719568","https://openalex.org/W2077806566","https://openalex.org/W2377006888","https://openalex.org/W2001064191","https://openalex.org/W1983434524"],"abstract_inverted_index":{"An":[0],"imbalance":[1],"in":[2,15,123,136],"the":[3,16,48,75,90,107,118,169,180,188,205,221,237,246],"proliferation":[4,101,119,230],"and":[5,18,25,55,64,102,176,201,231,250],"migration":[6],"of":[7,20,38,93,120,164,172,208,248],"vascular":[8,21,82],"smooth":[9],"muscle":[10],"cells":[11],"(VSMCs)":[12],"is":[13,72],"significant":[14],"onset":[17],"progression":[19,63],"diseases,":[22],"including":[23,47],"arteriosclerosis":[24],"restenosis":[26],"subsequent":[27],"to":[28,50,130,138,239],"vein":[29],"grafting":[30],"or":[31],"coronary":[32,66],"intervention.":[33],"Rosuvastatin,":[34],"a":[35,124,133,162,241],"selective":[36],"inhibitor":[37],"hydroxymethylglutaryl":[39],"coenzyme":[40],"A":[41],"(HMG-CoA)":[42],"reductase,":[43],"has":[44,236],"pharmacological":[45],"properties":[46],"ability":[49],"reduce":[51],"low-density":[52,57],"lipoprotein-cholesterol":[53,58],"(LDL-C)":[54],"very":[56],"(VLDL-C)":[59],"levels,":[60],"slow":[61],"atherosclerosis":[62,249],"improve":[65],"heart":[67],"disease":[68],"outcomes.":[69],"However,":[70],"little":[71],"known":[73],"concerning":[74],"molecular":[76,108,181],"mechanism":[77],"by":[78,195],"which":[79,159],"rosuvastatin":[80,94,115,142,153,186,217,226,235],"affects":[81],"cell":[83],"dynamics.":[84],"In":[85,219],"this":[86,145],"study,":[87],"we":[88,149],"studied":[89],"inhibitory":[91,166],"role":[92],"on":[95,168],"platelet-derived":[96],"growth":[97],"factor-BB":[98],"(PDGF-BB)-induced":[99],"VSMC":[100,157,229],"migration,":[103,158,232],"as":[104,106],"well":[105],"mechanisms":[109,182],"involved.":[110],"MTT":[111],"data":[112],"showed":[113,151,224],"that":[114,152,185,225,234],"markedly":[116],"inhibited":[117,187],"PDGF-BB-induced":[121,156,228],"VSMCs":[122,127],"time-dependent":[125],"manner.":[126],"are":[128],"able":[129],"dedifferentiate":[131],"into":[132,179],"proliferative":[134],"phenotype":[135,146],"response":[137],"PDGF-BB":[139],"stimulation;":[140],"however,":[141],"effectively":[143],"attenuated":[144],"switching.":[147],"Moreover,":[148],"also":[150],"significantly":[154],"suppressed":[155,227],"may":[160],"be":[161],"result":[163],"its":[165],"effect":[167],"protein":[170,190],"expression":[171],"matrix":[173],"metalloproteinase-2":[174],"(MMP2)":[175],"MMP9.":[177],"Investigation":[178],"involved":[183],"revealed":[184],"mitogen-activated":[189],"kinase":[191,199,211],"(MAPK)":[192],"signaling":[193],"pathway":[194],"downregulating":[196],"extracellular":[197],"signal-regulated":[198],"(ERK)":[200],"p38":[202],"MAPK,":[203],"although":[204],"phosphorylation":[206],"level":[207],"c-Jun":[209],"N-terminal":[210],"(c-JNK)":[212],"was":[213],"not":[214],"altered":[215],"following":[216],"treatment.":[218],"conclusion,":[220],"present":[222],"study":[223],"indicating":[233],"potential":[238],"become":[240],"promising":[242],"therapeutic":[243],"agent":[244],"for":[245],"treatment":[247],"restenosis.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}