{"id":"https://openalex.org/W1963979877","doi":"https://doi.org/10.1542/peds.2006-0598","title":"Direct Medical Cost of Influenza-Related Hospitalizations in Children","display_name":"Direct Medical Cost of Influenza-Related Hospitalizations in Children","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W1963979877","doi":"https://doi.org/10.1542/peds.2006-0598","mag":"1963979877","pmid":"https://pubmed.ncbi.nlm.nih.gov/17079533"},"language":"en","primary_location":{"id":"doi:10.1542/peds.2006-0598","doi":"https://doi.org/10.1542/peds.2006-0598","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2006-0598","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021146646","display_name":"Ron Keren","orcid":"https://orcid.org/0000-0002-9181-0927","observed_orcids":["https://orcid.org/0000-0002-9181-0927"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ron Keren","raw_affiliation_strings":["General Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Pediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107845445","display_name":"Theoklis E. Zaoutis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theoklis E. Zaoutis","raw_affiliation_strings":["Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066316220","display_name":"Stephanie Saddlemire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Saddlemire","raw_affiliation_strings":["General Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Pediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064891419","display_name":"Xianqun Luan","orcid":"https://orcid.org/0000-0002-2597-3760","observed_orcids":["https://orcid.org/0000-0002-2597-3760"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xian Qun Luan","raw_affiliation_strings":["Biostatistics and Epidemiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Epidemiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030055621","display_name":"Susan E Coffin","orcid":"https://orcid.org/0000-0001-9566-5600","observed_orcids":["https://orcid.org/0000-0001-9566-5600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan E. Coffin","raw_affiliation_strings":["Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021146646"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0996,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.96331361,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"118","issue":"5","first_page":"e1321","last_page":"e1327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza","display_name":"influenza","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pediatric-hospitalization","display_name":"pediatric hospitalization","score":0.7590000033378601},{"id":"https://openalex.org/keywords/direct-medical-costs","display_name":"direct medical costs","score":0.8769999742507935},{"id":"https://openalex.org/keywords/community-acquired-influenza","display_name":"community-acquired influenza","score":0.8169999718666077},{"id":"https://openalex.org/keywords/at-risk-children","display_name":"vulnerable children","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.5960000157356262},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.6050000190734863},{"id":"https://openalex.org/keywords/cost-predictors","display_name":"cost predictors","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9606179594993591},{"id":"https://openalex.org/C3017489713","wikidata":"https://www.wikidata.org/wiki/Q4686866","display_name":"Advisory committee","level":2,"score":0.6125649809837341},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.589530348777771},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.5653955340385437},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5305754542350769},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.5213754773139954},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.48024752736091614},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.46296170353889465},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4592151641845703},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3339027166366577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27007561922073364},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15118154883384705},{"id":"https://openalex.org/C3116431","wikidata":"https://www.wikidata.org/wiki/Q31728","display_name":"Public administration","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003365","descriptor_name":"Costs and Cost Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.2006-0598","doi":"https://doi.org/10.1542/peds.2006-0598","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2006-0598","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:17079533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17079533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3778758096","display_name":null,"funder_award_id":"H23/CCH32253-02","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G5060440674","display_name":"Prediciting Severe Neonatal Hyperbilirubinemia","funder_award_id":"K23HD043179","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1607091144","https://openalex.org/W1905652260","https://openalex.org/W1973047262","https://openalex.org/W1977775160","https://openalex.org/W1999006312","https://openalex.org/W2007670386","https://openalex.org/W2007883262","https://openalex.org/W2027106490","https://openalex.org/W2033564753","https://openalex.org/W2055113279","https://openalex.org/W2058144955","https://openalex.org/W2065420324","https://openalex.org/W2067041342","https://openalex.org/W2078742755","https://openalex.org/W2084653109","https://openalex.org/W2120098467","https://openalex.org/W2122034291","https://openalex.org/W2139841187","https://openalex.org/W2159850238"],"related_works":["https://openalex.org/W1965955024","https://openalex.org/W2008703366","https://openalex.org/W2068746781","https://openalex.org/W2373700193","https://openalex.org/W4295047610","https://openalex.org/W2076578786","https://openalex.org/W1994044758","https://openalex.org/W2737000843","https://openalex.org/W3097600994","https://openalex.org/W1972799334"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Our":[1],"goal":[2],"was":[3,29,59,143],"to":[4,18,151,187],"determine":[5],"the":[6,60,68,95,111,162,194,241],"cost":[7,63,69,137,202,245],"of":[8,21,34,64,70,86,100,138,185,203,217],"influenza-related":[9,65,141,204,231],"hospitalization":[10,23,139,196,232],"in":[11,105,206],"children":[12,103,207],"with":[13,45,121,193,229,237],"community-acquired":[14,46,91],"laboratory-confirmed":[15,47,92],"influenza":[16,48,52,93,118],"and":[17,38,74,180,183],"identify":[19],"predictors":[20],"high":[22],"costs.":[24,233],"PATIENTS":[25],"AND":[26],"METHODS:":[27],"This":[28],"a":[30,42,106],"retrospective":[31],"cohort":[32],"study":[33,96],"patients":[35,88,149,157,165,175,236],"21":[36,188],"years":[37,189],"younger":[39],"hospitalized":[40,89],"at":[41],"children's":[43],"hospital":[44],"during":[49,94],"4":[50],"consecutive":[51],"seasons":[53],"(2000-2004).":[54],"The":[55,134,201,215],"main":[56],"outcome":[57],"measure":[58],"direct":[61],"medical":[62,128,225],"hospitalizations,":[66],"including":[67],"diagnostics,":[71],"therapeutics,":[72],"room,":[73],"physician":[75],"services.":[76],"RESULTS:":[77],"Electronic":[78],"billing":[79],"data":[80],"were":[81,104,190],"retrievable":[82],"for":[83,90,109,140,148,156,159,243],"727":[84],"(98%)":[85],"745":[87],"period.":[97],"A":[98],"total":[99,136,169],"478":[101],"(66%)":[102],"high-risk":[107],"group":[108],"whom":[110],"Advisory":[112,122,219],"Committee":[113,123,220],"on":[114,124,161,221],"Immunization":[115,125,222],"Practices":[116],"recommended":[117],"vaccine":[119],"(patients":[120],"Practices-designated":[126,223],"chronic":[127,224],"conditions":[129,226,239],"or":[130],"aged":[131],"6-23":[132],"months).":[133],"mean":[135,168],"illness":[142],"13,159":[144],"dollars":[145,147,155],"(39,792":[146],"admitted":[150],"an":[152],"ICU;":[153],"7030":[154],"cared":[158],"exclusively":[160],"wards).":[163],"High-risk":[164],"had":[166],"higher":[167,211,230],"costs":[170,197],"(15,269":[171],"dollars)":[172],"than":[173,212],"low-risk":[174],"(9107":[176],"dollars).":[177],"Cardiac,":[178],"metabolic,":[179],"neurologic/neuromuscular":[181],"diseases":[182],"age":[184],"18":[186],"independently":[191],"associated":[192,228],"highest":[195],"(>15th":[198],"percentile).":[199],"CONCLUSIONS:":[200],"hospitalizations":[205],"may":[208],"be":[209],"considerably":[210],"previously":[213],"estimated.":[214],"presence":[216],"certain":[218],"is":[227],"Successfully":[234],"immunizing":[235],"these":[238],"has":[240],"potential":[242],"significant":[244],"savings.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}