{"id":"https://openalex.org/W1963966569","doi":"https://doi.org/10.1007/s11999-010-1702-0","title":"Methods for Assessing Bone Quality: A Review","display_name":"Methods for Assessing Bone Quality: A Review","publication_year":2010,"publication_date":"2010-11-29","ids":{"openalex":"https://openalex.org/W1963966569","doi":"https://doi.org/10.1007/s11999-010-1702-0","mag":"1963966569","pmid":"https://pubmed.ncbi.nlm.nih.gov/21116752","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126959"},"language":"en","primary_location":{"id":"doi:10.1007/s11999-010-1702-0","doi":"https://doi.org/10.1007/s11999-010-1702-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11999-010-1702-0","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics &amp; Related Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126959","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043462522","display_name":"Eve L. Donnelly","orcid":"https://orcid.org/0000-0001-8165-9568","observed_orcids":["https://orcid.org/0000-0001-8165-9568"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eve Donnelly","raw_affiliation_strings":["Mineralized Tissues Laboratory, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA, donnellye@hss.edu","Mineralized Tissues Laboratory, Hospital for Special Surgery, 535 East 70th Street, 10021, New York, NY, USA","e-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mineralized Tissues Laboratory, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA, donnellye@hss.edu","institution_ids":["https://openalex.org/I1281539108"]},{"raw_affiliation_string":"Mineralized Tissues Laboratory, Hospital for Special Surgery, 535 East 70th Street, 10021, New York, NY, USA","institution_ids":["https://openalex.org/I1281539108"]},{"raw_affiliation_string":"e-mail","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043462522"],"corresponding_institution_ids":["https://openalex.org/I1281539108"],"apc_list":null,"apc_paid":null,"fwci":8.2344,"has_fulltext":false,"cited_by_count":303,"citation_normalized_percentile":{"value":0.97623101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"469","issue":"8","first_page":"2128","last_page":"2138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-quality","display_name":"bone quality","score":1.0},{"id":"https://openalex.org/keywords/mechanical-properties-of-bone","display_name":"bone mechanical properties","score":0.7570000290870667},{"id":"https://openalex.org/keywords/bone-microarchitecture","display_name":"bone microarchitecture","score":0.7480000257492065},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.6579999923706055},{"id":"https://openalex.org/keywords/trabecular-morphology","display_name":"trabecular morphology","score":0.6690000295639038},{"id":"https://openalex.org/keywords/nanoindentation","display_name":"nanoindentation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"quantitative computed tomography","score":0.699999988079071},{"id":"https://openalex.org/keywords/micro-ct","display_name":"micro-CT","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bone-tissue-composition","display_name":"bone tissue composition","score":0.453000009059906},{"id":"https://openalex.org/keywords/collagen-cross-links","display_name":"collagen cross-links","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fracture-resistance","display_name":"fracture resistance","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5804200768470764},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.5714725852012634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5151061415672302},{"id":"https://openalex.org/C49326732","wikidata":"https://www.wikidata.org/wiki/Q1549892","display_name":"Nanoindentation","level":2,"score":0.49874305725097656},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.48764005303382874},{"id":"https://openalex.org/C2777425516","wikidata":"https://www.wikidata.org/wiki/Q17083560","display_name":"Quantitative computed tomography","level":4,"score":0.4551255404949188},{"id":"https://openalex.org/C31555180","wikidata":"https://www.wikidata.org/wiki/Q3523867","display_name":"Material properties","level":2,"score":0.4532445967197418},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.3907230496406555},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38812941312789917},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.32046252489089966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18066570162773132},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14481332898139954},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12257722020149231}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s11999-010-1702-0","doi":"https://doi.org/10.1007/s11999-010-1702-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11999-010-1702-0","pdf_url":null,"source":{"id":"https://openalex.org/S191421250","display_name":"Clinical Orthopaedics and Related Research","issn_l":"0009-921X","issn":["0009-921X","1528-1132"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Orthopaedics &amp; Related Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2411376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3126959","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126959","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Orthop Relat Res","raw_type":"Text"},{"id":"pmid:21116752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21116752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical orthopaedics and related research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2411376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126959","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G437974322","display_name":"Effects of bone tissue mineral and matrix properties on fracture incidence","funder_award_id":"F32AR056148","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W18311573","https://openalex.org/W122585317","https://openalex.org/W1218970471","https://openalex.org/W1532749597","https://openalex.org/W1752854822","https://openalex.org/W1901463649","https://openalex.org/W1948301689","https://openalex.org/W1964023148","https://openalex.org/W1966840648","https://openalex.org/W1966907599","https://openalex.org/W1968310052","https://openalex.org/W1972101280","https://openalex.org/W1972766017","https://openalex.org/W1974015559","https://openalex.org/W1974725047","https://openalex.org/W1987551491","https://openalex.org/W1990119775","https://openalex.org/W1992591531","https://openalex.org/W1993090130","https://openalex.org/W1996794759","https://openalex.org/W1998111806","https://openalex.org/W2000035078","https://openalex.org/W2001576085","https://openalex.org/W2003682724","https://openalex.org/W2004509444","https://openalex.org/W2005578054","https://openalex.org/W2006006050","https://openalex.org/W2006356329","https://openalex.org/W2009610732","https://openalex.org/W2012610216","https://openalex.org/W2015040655","https://openalex.org/W2016308888","https://openalex.org/W2016441011","https://openalex.org/W2018839559","https://openalex.org/W2021151569","https://openalex.org/W2021542350","https://openalex.org/W2022836308","https://openalex.org/W2023739541","https://openalex.org/W2024550196","https://openalex.org/W2026310458","https://openalex.org/W2027363033","https://openalex.org/W2028691139","https://openalex.org/W2029733751","https://openalex.org/W2031881697","https://openalex.org/W2031958859","https://openalex.org/W2032937109","https://openalex.org/W2036029654","https://openalex.org/W2036125852","https://openalex.org/W2036512532","https://openalex.org/W2037189818","https://openalex.org/W2038929699","https://openalex.org/W2040873725","https://openalex.org/W2046596180","https://openalex.org/W2048362355","https://openalex.org/W2051394874","https://openalex.org/W2053085627","https://openalex.org/W2058877817","https://openalex.org/W2059311075","https://openalex.org/W2060122532","https://openalex.org/W2060653586","https://openalex.org/W2061001238","https://openalex.org/W2061070333","https://openalex.org/W2062680483","https://openalex.org/W2062972212","https://openalex.org/W2066056548","https://openalex.org/W2066902264","https://openalex.org/W2072955115","https://openalex.org/W2073813406","https://openalex.org/W2074016952","https://openalex.org/W2078098175","https://openalex.org/W2078467681","https://openalex.org/W2083991002","https://openalex.org/W2084872529","https://openalex.org/W2086933933","https://openalex.org/W2087301624","https://openalex.org/W2087378917","https://openalex.org/W2094285126","https://openalex.org/W2096901253","https://openalex.org/W2103684286","https://openalex.org/W2109392661","https://openalex.org/W2109764750","https://openalex.org/W2119538833","https://openalex.org/W2121714292","https://openalex.org/W2137271817","https://openalex.org/W2141528524","https://openalex.org/W2144990076","https://openalex.org/W2148508563","https://openalex.org/W2159986807","https://openalex.org/W2160787234","https://openalex.org/W2164775171","https://openalex.org/W2170442655","https://openalex.org/W2481077326"],"related_works":["https://openalex.org/W4221053523","https://openalex.org/W2509835585","https://openalex.org/W4239422412","https://openalex.org/W2094250862","https://openalex.org/W2530017572","https://openalex.org/W1972101280","https://openalex.org/W2080450602","https://openalex.org/W2003090089","https://openalex.org/W2416973561","https://openalex.org/W2005578054"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bone":[1,23],"mass,":[2],"geometry,":[3,147],"and":[4,21,28,55,59,76,99,101,109,130,141,150,189,191,199,203,241],"tissue":[5,151,177],"material":[6,29,110,211],"properties":[7,93],"contribute":[8,32],"to":[9,33,67,71,160,244],"bone":[10,14,19,47,72,117,128,172,228,250],"structural":[11,107],"integrity.":[12],"Thus,":[13],"strength":[15,108],"arises":[16],"from":[17],"both":[18],"quantity":[20],"quality.":[22,251],"quality":[24,48],"encompasses":[25],"the":[26,43,158,165,209,215],"geometric":[27],"factors":[30],"that":[31],"fracture":[34],"resistance.":[35],"QUESTIONS/PURPOSES:":[36],"This":[37],"review":[38],"presents":[39],"an":[40],"overview":[41],"of":[42,116,167,171,249],"methods":[44,69],"for":[45,86,90,126,175,217],"assessing":[46,91],"across":[49],"multiple":[50],"length":[51],"scales,":[52],"their":[53,56],"outcomes,":[54],"relative":[57],"advantages":[58],"disadvantages.":[60],"METHODS:":[61],"A":[62],"PubMed":[63],"search":[64],"was":[65],"conducted":[66],"identify":[68],"related":[70],"mechanical":[73,92,240],"testing,":[74],"imaging,":[75,188],"compositional":[77,242],"analysis.":[78],"Using":[79],"various":[80],"exclusion":[81],"criteria,":[82],"articles":[83],"were":[84],"selected":[85],"inclusion.":[87],"RESULTS:":[88],"Methods":[89,125,174],"include":[94,106,113,120,132,144,164,179,196,208,214],"whole-bone,":[95],"bulk":[96],"tissue,":[97],"microbeam,":[98],"micro-":[100],"nanoindentation":[102],"testing":[103],"techniques.":[104,194],"Outcomes":[105,143,195],"modulus.":[111],"Advantages":[112,207],"direct":[114,169],"assessment":[115],"strength;":[118],"disadvantages":[119,163,213],"specimen":[121],"destruction":[122],"during":[123],"testing.":[124],"characterizing":[127],"geometry":[129],"microarchitecture":[131],"quantitative":[133,137],"CT,":[134,138],"high-resolution":[135,139],"peripheral":[136],"MRI,":[140],"micro-CT.":[142],"three-dimensional":[145],"whole-bone":[146],"trabecular":[148],"morphology,":[149],"mineral":[152,197],"density.":[153],"The":[154],"primary":[155],"advantage":[156],"is":[157],"ability":[159],"image":[161],"noninvasively;":[162],"lack":[166],"a":[168,218,246],"measure":[170],"strength.":[173],"measuring":[176],"composition":[178],"scanning":[180],"electron":[181],"microscopy,":[182],"vibrational":[183],"spectroscopy,":[184],"nuclear":[185],"magnetic":[186],"resonance":[187],"chemical":[190],"physical":[192],"analytical":[193],"density":[198],"crystallinity,":[200],"elemental":[201],"composition,":[202],"collagen":[204],"crosslink":[205],"composition.":[206],"detailed":[210],"characterization;":[212],"need":[216],"biopsy.":[219],"CONCLUSIONS:":[220],"Although":[221],"no":[222],"single":[223],"method":[224],"can":[225,234],"completely":[226],"characterize":[227],"quality,":[229],"current":[230],"noninvasive":[231],"imaging":[232],"techniques":[233,243],"be":[235],"combined":[236],"with":[237],"ex":[238],"vivo":[239],"provide":[245],"comprehensive":[247],"understanding":[248]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
