{"id":"https://openalex.org/W1963961538","doi":"https://doi.org/10.1177/0961203306069985","title":"cAMP response element modulator \u03b1 expression in patients with systemic lupus erythematosus","display_name":"cAMP response element modulator \u03b1 expression in patients with systemic lupus erythematosus","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1963961538","doi":"https://doi.org/10.1177/0961203306069985","mag":"1963961538","pmid":"https://pubmed.ncbi.nlm.nih.gov/17211988"},"language":"en","primary_location":{"id":"doi:10.1177/0961203306069985","doi":"https://doi.org/10.1177/0961203306069985","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0961203306069985","pdf_url":null,"source":{"id":"https://openalex.org/S115920904","display_name":"Lupus","issn_l":"0961-2033","issn":["0961-2033","1477-0962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048559252","display_name":"Vasileios C. Kyttaris","orcid":"https://orcid.org/0000-0001-7652-3826","observed_orcids":["https://orcid.org/0000-0001-7652-3826"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I2801951336","display_name":"Washington Hospital","ror":"https://ror.org/00jerb145","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801951336"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V C Kyttaris","raw_affiliation_strings":["Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA, Section of Rheumatology, Washington Hospital Center, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA, Section of Rheumatology, Washington Hospital Center, Washington, DC, USA","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I2801951336","https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Wang","raw_affiliation_strings":["Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049977820","display_name":"Y-T Juang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y-T Juang","raw_affiliation_strings":["Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084356090","display_name":"Arthur Weinstein","orcid":"https://orcid.org/0000-0002-7248-6623","observed_orcids":["https://orcid.org/0000-0002-7248-6623"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]},{"id":"https://openalex.org/I2801951336","display_name":"Washington Hospital","ror":"https://ror.org/00jerb145","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801951336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Weinstein","raw_affiliation_strings":["Section of Rheumatology, Washington Hospital Center, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, Washington Hospital Center, Washington, DC, USA","institution_ids":["https://openalex.org/I1285739803","https://openalex.org/I2801951336"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027542245","display_name":"George C. Tsokos","orcid":"https://orcid.org/0000-0001-9589-2360","observed_orcids":["https://orcid.org/0000-0001-9589-2360"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G C Tsokos","raw_affiliation_strings":["Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA, Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I148314036","https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027542245"],"corresponding_institution_ids":["https://openalex.org/I148314036","https://openalex.org/I92664306"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4334,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.66321877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"12","first_page":"840","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interleukin-2-promoter","display_name":"interleukin-2 promoter","score":0.8970000147819519},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9549999833106995},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8939999938011169},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.6710000038146973},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8221229314804077},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6186904311180115},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5558393001556396},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5398906469345093},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.45245346426963806},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44059687852859497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4304531514644623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40147191286087036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2153744399547577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11205971240997314},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0733567476272583},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05653339624404907},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051786","descriptor_name":"Cyclic AMP Response Element Modulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/0961203306069985","doi":"https://doi.org/10.1177/0961203306069985","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0961203306069985","pdf_url":null,"source":{"id":"https://openalex.org/S115920904","display_name":"Lupus","issn_l":"0961-2033","issn":["0961-2033","1477-0962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"journal-article"},{"id":"pmid:17211988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17211988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8211835501","display_name":"Lymphocyte Signaling Defects in Patients with Lupus","funder_award_id":"R01AI042269","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000897611","display_name":"Gene Transcription in SLE","funder_award_id":"R01AI049954","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1603845935","https://openalex.org/W1982548356","https://openalex.org/W1982595442","https://openalex.org/W2008521296","https://openalex.org/W2011738951","https://openalex.org/W2045577571","https://openalex.org/W2053085401","https://openalex.org/W2055522356","https://openalex.org/W2064999867","https://openalex.org/W2070527591","https://openalex.org/W2110670037","https://openalex.org/W2126414539","https://openalex.org/W2143139324","https://openalex.org/W2143146123"],"related_works":["https://openalex.org/W3026021983","https://openalex.org/W2010543739","https://openalex.org/W2126414539","https://openalex.org/W4311936193","https://openalex.org/W2005871909","https://openalex.org/W2108673463","https://openalex.org/W1479915365","https://openalex.org/W6908473506","https://openalex.org/W1603845935","https://openalex.org/W4383999226"],"abstract_inverted_index":{"T":[0,42,112],"cells":[1,43],"from":[2,44],"patients":[3,45,80],"with":[4,46,67],"systemic":[5],"lupus":[6],"erythematosus":[7],"(SLE)":[8],"have":[9,87],"high":[10,82],"levels":[11,38,53,63,89],"of":[12,84,90,95,103],"cAMP":[13],"response":[14],"element":[15],"modulator":[16],"(CREM)-alpha":[17],"which":[18],"bind":[19],"to":[20,86],"the":[21,58,101,110],"interleukin":[22],"(IL-2)":[23],"promoter":[24],"and":[25],"limit":[26],"IL-2":[27],"production.":[28],"In":[29],"this":[30],"case-controlled":[31],"study,":[32],"we":[33],"show":[34],"that":[35,99],"CREM-alpha":[36,61,91,104],"mRNA":[37,52,62],"were":[39],"higher":[40],"in":[41,108,115],"SLE":[47],"than":[48],"controls":[49],"while":[50],"CREB":[51],"did":[54,64],"not":[55,65],"differ":[56],"between":[57],"two":[59],"groups.":[60],"correlate":[66],"clinical":[68],"characteristics,":[69],"disease":[70],"activity":[71],"or":[72],"treatment.":[73],"Nevertheless,":[74],"there":[75],"was":[76],"a":[77],"trend":[78],"for":[79],"on":[81],"doses":[83],"corticosteroids":[85],"low":[88],"mRNA.":[92],"The":[93],"discovery":[94],"specific":[96],"non-toxic":[97],"medications":[98],"block":[100],"expression":[102],"may":[105],"prove":[106],"useful":[107],"reversing":[109],"aberrant":[111],"cell":[113],"function":[114],"SLE.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
