{"id":"https://openalex.org/W1963944657","doi":"https://doi.org/10.1038/220272a0","title":"Metabolic Cooperation between Genetically Marked Human Fibroblasts in Tissue Culture","display_name":"Metabolic Cooperation between Genetically Marked Human Fibroblasts in Tissue Culture","publication_year":1968,"publication_date":"1968-10-01","ids":{"openalex":"https://openalex.org/W1963944657","doi":"https://doi.org/10.1038/220272a0","mag":"1963944657"},"language":"en","primary_location":{"id":"doi:10.1038/220272a0","doi":"https://doi.org/10.1038/220272a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/220272a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022484519","display_name":"Theodore Friedmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THEODORE FRIEDMANN","raw_affiliation_strings":["Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland","Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037864999","display_name":"J. Edwin Seegmiller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. EDWIN SEEGMILLER","raw_affiliation_strings":["Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland","Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Section on Human Biochemical Genetics, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058606345","display_name":"John H. Subak-Sharpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146449","display_name":"MRC University of Glasgow Centre for Virus Research","ror":"https://ror.org/03vaer060","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210146449","https://openalex.org/I7882870","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JOHN H. SUBAK-SHARPE","raw_affiliation_strings":["MRC Experimental Virus Research Unit, University of Glasgow,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Experimental Virus Research Unit, University of Glasgow,","institution_ids":["https://openalex.org/I4210146449","https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":1.7925,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.82274998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"220","issue":"5164","first_page":"272","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxanthine-guanine-phosphoribosyltransferase","display_name":"hypoxanthine-guanine phosphoribosyltransferase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/purine-salvage-pathway","display_name":"purine salvage pathway","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lesch-nyhan-syndrome","display_name":"Lesch-Nyhan syndrome","score":0.9210000038146973},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.7509999871253967},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.4779999852180481},{"id":"https://openalex.org/keywords/nucleoside-incorporation","display_name":"nucleoside incorporation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/enzyme-deficiency","display_name":"enzyme deficiency","score":0.4860000014305115},{"id":"https://openalex.org/keywords/metabolic-cooperation","display_name":"metabolic cooperation","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C78179603","wikidata":"https://www.wikidata.org/wiki/Q14864606","display_name":"Hypoxanthine-guanine phosphoribosyltransferase","level":4,"score":0.8560073375701904},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.8157823085784912},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.7402790784835815},{"id":"https://openalex.org/C71615608","wikidata":"https://www.wikidata.org/wiki/Q24720082","display_name":"Purine nucleoside phosphorylase","level":4,"score":0.7278887629508972},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.7250959873199463},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.6449292898178101},{"id":"https://openalex.org/C194101687","wikidata":"https://www.wikidata.org/wiki/Q583813","display_name":"Nucleotide salvage","level":4,"score":0.6362251043319702},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6304749846458435},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6146982908248901},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5885515213012695},{"id":"https://openalex.org/C2777991568","wikidata":"https://www.wikidata.org/wiki/Q7187556","display_name":"Phosphoribosyltransferase","level":5,"score":0.5815140604972839},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5387564301490784},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5379031896591187},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.4638941287994385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4397273659706116},{"id":"https://openalex.org/C2909697302","wikidata":"https://www.wikidata.org/wiki/Q14864606","display_name":"Hypoxanthine Phosphoribosyltransferase","level":5,"score":0.4136626720428467},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.41128358244895935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3834850490093231},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2046557366847992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16550061106681824},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/220272a0","doi":"https://doi.org/10.1038/220272a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/220272a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6018000245094299}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1541896646","https://openalex.org/W2026099271","https://openalex.org/W2037480066","https://openalex.org/W2053536091","https://openalex.org/W2056306453","https://openalex.org/W2081943361","https://openalex.org/W2120613619"],"related_works":["https://openalex.org/W808517834","https://openalex.org/W2520238671","https://openalex.org/W6987271155","https://openalex.org/W2055693391","https://openalex.org/W1983001081","https://openalex.org/W2073782571","https://openalex.org/W1570900932","https://openalex.org/W1997285960","https://openalex.org/W2072933554","https://openalex.org/W1997819620"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
