{"id":"https://openalex.org/W1963938153","doi":"https://doi.org/10.1142/s2339547814500058","title":"A combined magnetophoresis/dielectrophoresis based microbead array as high-throughput biomolecular tweezers","display_name":"A combined magnetophoresis/dielectrophoresis based microbead array as high-throughput biomolecular tweezers","publication_year":2014,"publication_date":"2014-02-19","ids":{"openalex":"https://openalex.org/W1963938153","doi":"https://doi.org/10.1142/s2339547814500058","mag":"1963938153"},"language":"en","primary_location":{"id":"doi:10.1142/s2339547814500058","doi":"https://doi.org/10.1142/s2339547814500058","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s2339547814500058","pdf_url":null,"source":{"id":"https://openalex.org/S4210220183","display_name":"TECHNOLOGY","issn_l":"2339-5478","issn":["2339-5478","2345-7740"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TECHNOLOGY","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110392545","display_name":"Lizhi Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizhi Cao","raw_affiliation_strings":["Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003417709","display_name":"Zhengchun Peng","orcid":"https://orcid.org/0000-0002-7114-1797","observed_orcids":["https://orcid.org/0000-0002-7114-1797"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengchun Peng","raw_affiliation_strings":["Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, USA","Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065031384","display_name":"Wilbur Aaron Lam","orcid":"https://orcid.org/0000-0002-0325-7990","observed_orcids":["https://orcid.org/0000-0002-0325-7990"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilbur Lam","raw_affiliation_strings":["Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, USA","Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073026508","display_name":"Thomas Harrison Barker","orcid":"https://orcid.org/0000-0002-3218-8111","observed_orcids":["https://orcid.org/0000-0002-3218-8111"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H. Barker","raw_affiliation_strings":["Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1544,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4969087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"02","issue":"01","first_page":"23","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10490","display_name":"Orbital Angular Momentum in Optics","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetophoresis","display_name":"magnetophoresis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dielectrophoresis","display_name":"dielectrophoresis","score":1.0},{"id":"https://openalex.org/keywords/paramagnetic-beads","display_name":"paramagnetic beads","score":0.7910000085830688},{"id":"https://openalex.org/keywords/biomolecular-interactions","display_name":"biomolecular interactions","score":0.7279999852180481},{"id":"https://openalex.org/keywords/antibody-antigen-binding","display_name":"antibody-antigen binding","score":0.9509999752044678},{"id":"https://openalex.org/keywords/high-throughput-characterization","display_name":"high-throughput characterization","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776363448","wikidata":"https://www.wikidata.org/wiki/Q12008238","display_name":"Microbead (research)","level":2,"score":0.9348804950714111},{"id":"https://openalex.org/C106825181","wikidata":"https://www.wikidata.org/wiki/Q902890","display_name":"Dielectrophoresis","level":3,"score":0.8195359706878662},{"id":"https://openalex.org/C109386097","wikidata":"https://www.wikidata.org/wiki/Q1053956","display_name":"Bead","level":2,"score":0.6885645389556885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.649752676486969},{"id":"https://openalex.org/C105480513","wikidata":"https://www.wikidata.org/wiki/Q6731630","display_name":"Magnetic tweezers","level":3,"score":0.6137799620628357},{"id":"https://openalex.org/C2993110782","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic bead","level":2,"score":0.6091477870941162},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.5728023648262024},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.5678809285163879},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5567681789398193},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.4721638858318329},{"id":"https://openalex.org/C2779833257","wikidata":"https://www.wikidata.org/wiki/Q2663154","display_name":"Magnetic separation","level":2,"score":0.4561062157154083},{"id":"https://openalex.org/C20198109","wikidata":"https://www.wikidata.org/wiki/Q1066633","display_name":"Optical tweezers","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.3056842088699341},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.2426547110080719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19456487894058228},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.15067899227142334},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12627866864204407},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.11884307861328125},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.11732763051986694},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08302974700927734},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1142/s2339547814500058","doi":"https://doi.org/10.1142/s2339547814500058","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s2339547814500058","pdf_url":null,"source":{"id":"https://openalex.org/S4210220183","display_name":"TECHNOLOGY","issn_l":"2339-5478","issn":["2339-5478","2345-7740"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TECHNOLOGY","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W208653037","https://openalex.org/W1994810393","https://openalex.org/W1998282575","https://openalex.org/W2026549867","https://openalex.org/W2028050830","https://openalex.org/W2036095526","https://openalex.org/W2041014993","https://openalex.org/W2070344022","https://openalex.org/W2072485067","https://openalex.org/W2087427893","https://openalex.org/W2115979056"],"related_works":["https://openalex.org/W4387564344","https://openalex.org/W2091275458","https://openalex.org/W2774021446","https://openalex.org/W2929245131","https://openalex.org/W2005190307","https://openalex.org/W3161901283","https://openalex.org/W2100484511","https://openalex.org/W1785569162","https://openalex.org/W2052288619","https://openalex.org/W2270068801"],"abstract_inverted_index":{"In":[0],"this":[1],"paper":[2],"we":[3],"describe":[4],"a":[5,33],"combined":[6],"magnetophoresis":[7],"(MAP)":[8],"and":[9,45,74,93],"dielectrophoresis":[10],"(DEP)":[11,47],"based":[12],"platform":[13],"for":[14],"high":[15],"throughput":[16],"characterization":[17],"of":[18,28,40,78],"specific":[19,84],"biomolecular":[20],"interactions.":[21],"The":[22],"magnetic":[23,30,34,44,72],"manipulation":[24],"enables":[25],"parallel":[26],"loading":[27],"individual":[29],"beads":[31,70],"onto":[32,71],"pad":[35,94],"array,":[36],"while":[37],"the":[38,76],"combination":[39],"tightly":[41],"controlled":[42],"opposing":[43],"dielectrophoretic":[46],"forces":[48],"is":[49],"employed":[50],"to":[51,62,81],"produce":[52],"characteristic":[53],"out-of-plane":[54],"(z-axial)":[55],"bead":[56,92],"displacement.":[57],"We":[58],"optimized":[59],"design":[60],"parameters":[61],"evenly":[63],"load":[64],"2.8":[65],"\u03bcm":[66],"biomolecule":[67],"functionalized":[68],"paramagnetic":[69],"pads,":[73],"demonstrate":[75],"ability":[77],"our":[79],"tweezers":[80],"discriminate":[82],"between":[83,91],"antibody-antigen":[85],"bond":[86,89],"from":[87],"non-specific":[88],"formed":[90],"surface.":[95]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
