{"id":"https://openalex.org/W1963894699","doi":"https://doi.org/10.1016/j.molmed.2011.06.001","title":"Revisiting the TCA cycle: signaling to tumor formation","display_name":"Revisiting the TCA cycle: signaling to tumor formation","publication_year":2011,"publication_date":"2011-07-24","ids":{"openalex":"https://openalex.org/W1963894699","doi":"https://doi.org/10.1016/j.molmed.2011.06.001","mag":"1963894699","pmid":"https://pubmed.ncbi.nlm.nih.gov/21764377","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3205302"},"language":"en","primary_location":{"id":"doi:10.1016/j.molmed.2011.06.001","doi":"https://doi.org/10.1016/j.molmed.2011.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molmed.2011.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3205302","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006141192","display_name":"Nuno Raimundo","orcid":"https://orcid.org/0000-0002-5988-9129","observed_orcids":["https://orcid.org/0000-0002-5988-9129"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nuno Raimundo","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA. nuno.raimundo@yale.edu","Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA. nuno.raimundo@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042047926","display_name":"Bora E. Baysal","orcid":"https://orcid.org/0000-0003-3382-1545","observed_orcids":["https://orcid.org/0000-0003-3382-1545"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bora E. Baysal","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520","Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079476247","display_name":"Gerald S. Shadel","orcid":"https://orcid.org/0000-0003-2899-8717","observed_orcids":["https://orcid.org/0000-0003-2899-8717"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald S. Shadel","raw_affiliation_strings":["Department of Genetics, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520","Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520","Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, BML 369, 310 Cedar St, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.6428,"has_fulltext":false,"cited_by_count":271,"citation_normalized_percentile":{"value":0.86553672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"17","issue":"11","first_page":"641","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-formation","display_name":"tumor formation","score":0.781000018119812},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.6159999966621399},{"id":"https://openalex.org/keywords/idh-mutation","display_name":"IDH mutation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/succinate-dehydrogenase-mutations","display_name":"succinate dehydrogenase mutations","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hypoxia-pathway","display_name":"hypoxia pathway","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.925000011920929},{"id":"https://openalex.org/keywords/tca-cycle-metabolites","display_name":"TCA cycle metabolites","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-suppressor-signaling","display_name":"tumor suppressor signaling","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.8575398325920105},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.7900234460830688},{"id":"https://openalex.org/C106302636","wikidata":"https://www.wikidata.org/wiki/Q21107515","display_name":"Fumarase","level":3,"score":0.6990768909454346},{"id":"https://openalex.org/C2781330172","wikidata":"https://www.wikidata.org/wiki/Q412837","display_name":"Succinate dehydrogenase","level":3,"score":0.5761269927024841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5390827655792236},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5208214521408081},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5117373466491699},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4989049434661865},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.48157382011413574},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.46751004457473755},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4428275525569916},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4343443810939789},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42851877212524414},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.42599767446517944},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38463854789733887},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3648854196071625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32322031259536743},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2881671190261841},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11870118975639343},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09706586599349976},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molmed.2011.06.001","doi":"https://doi.org/10.1016/j.molmed.2011.06.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molmed.2011.06.001","pdf_url":null,"source":{"id":"https://openalex.org/S64855341","display_name":"Trends in Molecular Medicine","issn_l":"1471-4914","issn":["1471-4914","1471-499X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:21764377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21764377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3205302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3205302","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Mol Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3205302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3205302","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Mol Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426008686","display_name":"Cellular Responses to Oxidative Stress in Models of Colon Cancer Development","funder_award_id":"P01ES011163","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1699743394","display_name":"Epigenetic Regulation of Mitochondiral Complex II","funder_award_id":"R01CA112364","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2606566589","display_name":null,"funder_award_id":"ES011163","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G586469878","display_name":null,"funder_award_id":"CA112364","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W135930319","https://openalex.org/W166059795","https://openalex.org/W1528834211","https://openalex.org/W1965824315","https://openalex.org/W1967291345","https://openalex.org/W1969899640","https://openalex.org/W1970540546","https://openalex.org/W1977015709","https://openalex.org/W1987519315","https://openalex.org/W1988742700","https://openalex.org/W1993672713","https://openalex.org/W1994414101","https://openalex.org/W1995675594","https://openalex.org/W2002392031","https://openalex.org/W2004183689","https://openalex.org/W2004805159","https://openalex.org/W2005917601","https://openalex.org/W2009447162","https://openalex.org/W2011300705","https://openalex.org/W2014892666","https://openalex.org/W2015755329","https://openalex.org/W2018171566","https://openalex.org/W2022245796","https://openalex.org/W2022451432","https://openalex.org/W2025719835","https://openalex.org/W2028117213","https://openalex.org/W2029254739","https://openalex.org/W2041253360","https://openalex.org/W2041596211","https://openalex.org/W2042472611","https://openalex.org/W2043251964","https://openalex.org/W2055255976","https://openalex.org/W2056811326","https://openalex.org/W2057199368","https://openalex.org/W2059747280","https://openalex.org/W2060628991","https://openalex.org/W2063439260","https://openalex.org/W2065664525","https://openalex.org/W2067382049","https://openalex.org/W2068414886","https://openalex.org/W2068892354","https://openalex.org/W2074820523","https://openalex.org/W2077954885","https://openalex.org/W2078972833","https://openalex.org/W2080452140","https://openalex.org/W2097259163","https://openalex.org/W2109917395","https://openalex.org/W2118880610","https://openalex.org/W2119169141","https://openalex.org/W2119457772","https://openalex.org/W2120370940","https://openalex.org/W2122380998","https://openalex.org/W2125955965","https://openalex.org/W2126511952","https://openalex.org/W2126694133","https://openalex.org/W2126817554","https://openalex.org/W2131473358","https://openalex.org/W2131860315","https://openalex.org/W2131964237","https://openalex.org/W2132878122","https://openalex.org/W2135549828","https://openalex.org/W2136749294","https://openalex.org/W2144575277","https://openalex.org/W2151215883","https://openalex.org/W2156714520","https://openalex.org/W2166702961","https://openalex.org/W2170526668","https://openalex.org/W2171026968","https://openalex.org/W6606763518"],"related_works":["https://openalex.org/W2057199368","https://openalex.org/W1973352921","https://openalex.org/W3156279634","https://openalex.org/W2068385489","https://openalex.org/W2130262598","https://openalex.org/W2392881786","https://openalex.org/W4238252493","https://openalex.org/W2318659688","https://openalex.org/W2511175281","https://openalex.org/W2754664643"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
