{"id":"https://openalex.org/W1963837579","doi":"https://doi.org/10.1089/zeb.2012.0764","title":"Reducing the Noise in Behavioral Assays: Sex and Age in Adult Zebrafish Locomotion","display_name":"Reducing the Noise in Behavioral Assays: Sex and Age in Adult Zebrafish Locomotion","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1963837579","doi":"https://doi.org/10.1089/zeb.2012.0764","mag":"1963837579","pmid":"https://pubmed.ncbi.nlm.nih.gov/23244690","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3528087"},"language":"en","primary_location":{"id":"doi:10.1089/zeb.2012.0764","doi":"https://doi.org/10.1089/zeb.2012.0764","is_oa":true,"landing_page_url":"https://doi.org/10.1089/zeb.2012.0764","pdf_url":null,"source":{"id":"https://openalex.org/S164728804","display_name":"Zebrafish","issn_l":"1545-8547","issn":["1545-8547","1557-8542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1089/zeb.2012.0764","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036188490","display_name":"Catelyn Philpott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catelyn Philpott","raw_affiliation_strings":["Lincoln K\u20138 Choice School","Lincoln K-8 Choice School, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lincoln K\u20138 Choice School","institution_ids":[]},{"raw_affiliation_string":"Lincoln K-8 Choice School, Rochester, Minnesota, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057013164","display_name":"Corey J. Donack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corey J. Donack","raw_affiliation_strings":["Lincoln K\u20138 Choice School","Lincoln K\u20138 Choice School, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lincoln K\u20138 Choice School","institution_ids":[]},{"raw_affiliation_string":"Lincoln K\u20138 Choice School, Rochester, Minnesota","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056815195","display_name":"Margot A. Cousin","orcid":"https://orcid.org/0000-0002-6119-9346","observed_orcids":["https://orcid.org/0000-0002-6119-9346"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margot A. Cousin","raw_affiliation_strings":["Mayo Clinic","Department of Biochemistry and Molecular Biology, Integrated Science Education Outreach, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Integrated Science Education Outreach, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013874670","display_name":"Chris Pierret","orcid":"https://orcid.org/0000-0003-0000-4813","observed_orcids":["https://orcid.org/0000-0003-0000-4813"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chris Pierret","raw_affiliation_strings":["Mayo Clinic","Department of Biochemistry and Molecular Biology, Integrated Science Education Outreach, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Integrated Science Education Outreach, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013874670"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.911,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.66724259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"191","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12014","display_name":"Fish biology, ecology, and behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2309","display_name":"Nature and Landscape Conservation"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8790000081062317},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.9369999766349792},{"id":"https://openalex.org/keywords/behavioral-assays","display_name":"behavioral assays","score":0.6589999794960022},{"id":"https://openalex.org/keywords/confounding-factors","display_name":"confounding factors","score":0.8320000171661377},{"id":"https://openalex.org/keywords/adult-zebrafish","display_name":"adult zebrafish","score":0.6949999928474426},{"id":"https://openalex.org/keywords/behavioral-phenotyping","display_name":"behavioral phenotyping","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.891103208065033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7550026178359985},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4207513630390167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0985824465751648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09338569641113281},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07919943332672119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1089/zeb.2012.0764","doi":"https://doi.org/10.1089/zeb.2012.0764","is_oa":true,"landing_page_url":"https://doi.org/10.1089/zeb.2012.0764","pdf_url":null,"source":{"id":"https://openalex.org/S164728804","display_name":"Zebrafish","issn_l":"1545-8547","issn":["1545-8547","1557-8542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2694034","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3528087","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3528087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3528087","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"Text"},{"id":"pmid:23244690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23244690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1089/zeb.2012.0764","doi":"https://doi.org/10.1089/zeb.2012.0764","is_oa":true,"landing_page_url":"https://doi.org/10.1089/zeb.2012.0764","pdf_url":null,"source":{"id":"https://openalex.org/S164728804","display_name":"Zebrafish","issn_l":"1545-8547","issn":["1545-8547","1557-8542"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zebrafish","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8875974309","display_name":"Mayo Clinic Center for Translational Science Activities","funder_award_id":"UL1RR024150","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1976206947","https://openalex.org/W1992907057","https://openalex.org/W1993952450","https://openalex.org/W1998353736","https://openalex.org/W1998512131","https://openalex.org/W2047445649","https://openalex.org/W2051947514","https://openalex.org/W2055672898","https://openalex.org/W2089288067","https://openalex.org/W2117132892","https://openalex.org/W2121927733","https://openalex.org/W2123191929","https://openalex.org/W2128866923","https://openalex.org/W2131347141","https://openalex.org/W2133445454","https://openalex.org/W2141176851","https://openalex.org/W2159898375","https://openalex.org/W2164700595"],"related_works":["https://openalex.org/W2619295859","https://openalex.org/W4396597311","https://openalex.org/W4405038045","https://openalex.org/W4388374652","https://openalex.org/W2071531233","https://openalex.org/W4396772614","https://openalex.org/W7151420077","https://openalex.org/W1156899037","https://openalex.org/W7097034613","https://openalex.org/W1979933042"],"abstract_inverted_index":{"Many":[0],"assays":[1,50],"are":[2],"used":[3,89],"in":[4,90,111,122,156,166,196],"animal":[5],"model":[6,25,60],"systems":[7],"to":[8,44,80,139,147,173],"measure":[9],"specific":[10],"human":[11],"disease-related":[12],"behaviors.":[13,73],"The":[14],"use":[15,57],"of":[16,48,72,86],"both":[17],"adult":[18],"and":[19,33,66,84,108,186,192],"larval":[20],"zebrafish":[21,135,152,160,179],"as":[22,124,134],"a":[23,70,75,119,128],"behavioral":[24,181],"is":[26],"gaining":[27],"popularity.":[28],"As":[29,74],"this":[30,103],"work":[31,94],"progresses":[32],"potentially":[34],"translates":[35],"into":[36],"new":[37],"treatments,":[38],"we":[39,105],"must":[40],"do":[41],"our":[42],"best":[43],"improve":[45],"the":[46,58,82,99,178],"sensitivity":[47],"these":[49,194],"by":[51],"reducing":[52],"confounding":[53],"factors.":[54],"Scientists":[55],"who":[56],"mouse":[59],"system":[61],"have":[62,78,170],"demonstrated":[63],"that":[64,116,175],"sex":[65,85,107,126,187],"age":[67,83,109,117,130,185],"can":[68],"influence":[69],"number":[71],"community,":[76],"they":[77,137],"moved":[79],"report":[81,193],"all":[87],"animals":[88],"their":[91,189,197],"studies.":[92],"Zebrafish":[93],"does":[95],"not":[96],"yet":[97],"carry":[98],"same":[100],"mandate.":[101],"In":[102,132],"study,":[104],"evaluated":[106],"differences":[110],"locomotion":[112,155],"behavior.":[113],"We":[114],"found":[115],"was":[118,125],"significant":[120],"factor":[121],"locomotion,":[123],"within":[127,188],"given":[129],"group.":[131],"short,":[133],"age,":[136],"appear":[138],"show":[140],"less":[141],"base":[142],"level":[143],"locomotion.":[144],"With":[145],"regard":[146],"sex,":[148],"younger":[149],"(10":[150],"months)":[151,162],"showed":[153,163],"more":[154,164],"males,":[157],"while":[158],"older":[159],"(22":[161],"movement":[165],"females.":[167],"These":[168],"findings":[169],"led":[171],"us":[172],"suggest":[174],"those":[176],"using":[177],"for":[180,184],"studies":[182],"control":[183],"experimental":[190],"design":[191],"descriptors":[195],"methods.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}