{"id":"https://openalex.org/W1963804606","doi":"https://doi.org/10.1136/mp.49.2.m112","title":"Detection of clonal immunoglobulin gene rearrangements in the peripheral blood progenitor cells of patients with multiple myeloma: the potential role of purging with CD34 positive selection","display_name":"Detection of clonal immunoglobulin gene rearrangements in the peripheral blood progenitor cells of patients with multiple myeloma: the potential role of purging with CD34 positive selection","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W1963804606","doi":"https://doi.org/10.1136/mp.49.2.m112","mag":"1963804606","pmid":"https://pubmed.ncbi.nlm.nih.gov/16696051","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/408031"},"language":"en","primary_location":{"id":"doi:10.1136/mp.49.2.m112","doi":"https://doi.org/10.1136/mp.49.2.m112","is_oa":true,"landing_page_url":"https://doi.org/10.1136/mp.49.2.m112","pdf_url":"https://mp.bmj.com/content/molpath/49/2/M112.full.pdf","source":{"id":"https://openalex.org/S68106708","display_name":"Molecular Pathology","issn_l":"1366-8714","issn":["1366-8714","1472-4154"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://mp.bmj.com/content/molpath/49/2/M112.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063301766","display_name":"Roger G. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R G Owen","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109250940","display_name":"Andy P. Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A P Haynes","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004618702","display_name":"Paul Evans","orcid":"https://orcid.org/0000-0002-7915-0946","observed_orcids":["https://orcid.org/0000-0002-7915-0946"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P A Evans","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102969295","display_name":"Robert James Johnson","orcid":"https://orcid.org/0000-0002-4256-7457","observed_orcids":["https://orcid.org/0000-0002-4256-7457"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R J Johnson","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001511648","display_name":"Andy C. Rawstron","orcid":"https://orcid.org/0000-0003-0798-9790","observed_orcids":["https://orcid.org/0000-0003-0798-9790"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A C Rawstron","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072267975","display_name":"Grant McQuaker","orcid":"https://orcid.org/0000-0001-9462-4233","observed_orcids":["https://orcid.org/0000-0001-9462-4233"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G McQuaker","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083761453","display_name":"Graeme Smith","orcid":"https://orcid.org/0000-0003-1694-4885","observed_orcids":["https://orcid.org/0000-0003-1694-4885"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G M Smith","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113445100","display_name":"M. C. Galvin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M C Galvin","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109916936","display_name":"D. L. Barnard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D L Barnard","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035489508","display_name":"Nigel H. Russell","orcid":"https://orcid.org/0000-0003-1893-8155","observed_orcids":["https://orcid.org/0000-0003-1893-8155"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N H Russell","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112827367","display_name":"J. Anthony Child","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J A Child","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]},{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]},{"id":"https://openalex.org/I4210160796","display_name":"Pinderfields Hospital","ror":"https://ror.org/04tbm0m52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210160067","https://openalex.org/I4210160796"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G J Morgan","raw_affiliation_strings":["Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","Department of Haematology, City Hospital, Hucknall Road, Nottingham","Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","Department of Haematology, St James's University Hospital, Beckett Street, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haematological Oncology, The General Infirmary at Leeds, Great George Street, Leeds","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Department of Haematology, City Hospital, Hucknall Road, Nottingham","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"Department of Haematology, Pinderfields General Hospital, Aberford Road, Wakefield","institution_ids":["https://openalex.org/I4210160796"]},{"raw_affiliation_string":"Department of Haematology, St James's University Hospital, Beckett Street, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4681,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60970088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"2","first_page":"M112","last_page":"M117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/peripheral-blood-progenitor-cells","display_name":"peripheral blood progenitor cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6494140625},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5961365103721619},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5549097657203674},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5531085729598999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5275147557258606},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5035735964775085},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.4907627999782562},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.47638481855392456},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4687989354133606},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.45210760831832886},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.4378056526184082},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42040184140205383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3953108489513397},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2855238914489746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18583792448043823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16348952054977417}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1136/mp.49.2.m112","doi":"https://doi.org/10.1136/mp.49.2.m112","is_oa":true,"landing_page_url":"https://doi.org/10.1136/mp.49.2.m112","pdf_url":"https://mp.bmj.com/content/molpath/49/2/M112.full.pdf","source":{"id":"https://openalex.org/S68106708","display_name":"Molecular Pathology","issn_l":"1366-8714","issn":["1366-8714","1472-4154"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:408031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/408031","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Mol Pathol","raw_type":"Text"},{"id":"pmid:16696051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16696051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical molecular pathology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:molpath:49/2/M112","doi":null,"is_oa":false,"landing_page_url":"http://mp.bmj.com/cgi/content/short/49/2/M112","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/mp.49.2.m112","doi":"https://doi.org/10.1136/mp.49.2.m112","is_oa":true,"landing_page_url":"https://doi.org/10.1136/mp.49.2.m112","pdf_url":"https://mp.bmj.com/content/molpath/49/2/M112.full.pdf","source":{"id":"https://openalex.org/S68106708","display_name":"Molecular Pathology","issn_l":"1366-8714","issn":["1366-8714","1472-4154"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963804606.pdf","grobid_xml":"https://content.openalex.org/works/W1963804606.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W84991684","https://openalex.org/W197334239","https://openalex.org/W2025617996","https://openalex.org/W2034699896","https://openalex.org/W2074289657","https://openalex.org/W2130358507","https://openalex.org/W2162992800","https://openalex.org/W2242711566","https://openalex.org/W2288060887","https://openalex.org/W2295603781","https://openalex.org/W2301504565","https://openalex.org/W2324339443","https://openalex.org/W2373939791","https://openalex.org/W2408688530","https://openalex.org/W2416550358","https://openalex.org/W2416846259","https://openalex.org/W2418641834","https://openalex.org/W2434562180","https://openalex.org/W2461838534","https://openalex.org/W3112391997"],"related_works":["https://openalex.org/W2034699896","https://openalex.org/W1996798479","https://openalex.org/W2538365970","https://openalex.org/W2411051628","https://openalex.org/W2003367269","https://openalex.org/W2328274820","https://openalex.org/W7217254898","https://openalex.org/W7216619417","https://openalex.org/W2079893206","https://openalex.org/W2128608897"],"abstract_inverted_index":{"Aims-To":[0],"determine":[1],"the":[2,24,40,58,63,84,96,139,144,166,170,177,181,190],"extent":[3],"of":[4,8,27,42,62,70,98,118,141,143,176,213],"clonal":[5,43,99,167],"cell":[6,12],"contamination":[7],"peripheral":[9],"blood":[10],"progenitor":[11],"(PBPC)":[13],"collections":[14,31,208],"in":[15,108,115,138,151,169,189,201,209],"patients":[16,34,65,146,214],"with":[17,35,50,75,105,128,197,215],"multiple":[18],"myeloma":[19],"(MM)":[20],"and":[21,89,121,217],"to":[22,123,126,164],"assess":[23],"purging":[25],"efficacy":[26],"CD34":[28,71,87,149,171,191,222],"positive":[29,72,88,172,192,223],"selection.Methods-PBPC":[30],"from":[32,60],"29":[33,64,119],"MM":[36,216],"were":[37,66,92,113,136],"analysed":[38],"for":[39,95],"presence":[41,97],"immunoglobulin":[44],"heavy":[45],"chain":[46],"(IgH)":[47],"gene":[48],"rearrangements":[49,103,135],"a":[51,154,198,210],"fluorescence":[52],"based":[53],"PCR":[54],"technique.":[55],"In":[56,81,174],"addition,":[57],"PBPC":[59,140,207],"eight":[61,145],"\"purged\"":[67],"by":[68,221],"selection":[69],"haematopoietic":[73],"progenitors":[74],"an":[76],"avidin-biotin":[77],"immunoabsorption":[78],"column":[79],"(Ceprate).":[80],"each":[82],"case":[83],"unmanipulated":[85],"PBPC,":[86],"waste":[90],"fractions":[91],"all":[93],"assessed":[94],"IgH":[100,102],"rearrangements.Results-Clonal":[101],"(identical":[104],"those":[106,127],"demonstrated":[107,114,188],"diagnostic":[109],"bone":[110,131],"marrow":[111,132],"samples)":[112],"10":[116],"(35%)":[117],"cases":[120,180],"seemed":[122],"be":[124,187,219],"confined":[125],"significant":[129,199,211],"residual":[130],"disease.":[133],"Clonal":[134],"evident":[137],"two":[142],"who":[147],"underwent":[148],"selection;":[150],"both":[152],"instances":[153],"\"clonal":[155],"purge\"":[156],"was":[157,161],"seen":[158],"as":[159],"it":[160],"not":[162,186],"possible":[163],"demonstrate":[165],"rearrangement":[168],"fraction.":[173],"four":[175],"six":[178],"remaining":[179],"normal":[182],"polyclonal":[183],"fingerprint":[184],"could":[185],"fraction,":[193],"which":[194],"is":[195],"consistent":[196],"reduction":[200],"contaminating":[202],"B":[203],"cells.Conclusions-Clonal":[204],"cells":[205],"contaminate":[206],"proportion":[212],"may":[218],"eliminated":[220],"selection.":[224]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}