{"id":"https://openalex.org/W1963798231","doi":"https://doi.org/10.1016/j.taap.2009.01.022","title":"Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane","display_name":"Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane","publication_year":2009,"publication_date":"2009-02-07","ids":{"openalex":"https://openalex.org/W1963798231","doi":"https://doi.org/10.1016/j.taap.2009.01.022","mag":"1963798231","pmid":"https://pubmed.ncbi.nlm.nih.gov/19371605"},"language":"en","primary_location":{"id":"doi:10.1016/j.taap.2009.01.022","doi":"https://doi.org/10.1016/j.taap.2009.01.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2009.01.022","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015601396","display_name":"Galya Orr","orcid":"https://orcid.org/0000-0002-5552-2151","observed_orcids":["https://orcid.org/0000-0002-5552-2151"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Galya Orr","raw_affiliation_strings":["Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA. galya.orr@pnl.gov","Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA. galya.orr@pnl.gov","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029657260","display_name":"David J. Panther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Panther","raw_affiliation_strings":["Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044739865","display_name":"Kaylyn J. Cassens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaylyn J. Cassens","raw_affiliation_strings":["Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059962429","display_name":"Jaclyn L. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaclyn L. Phillips","raw_affiliation_strings":["Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Materials Sciences, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, WA 99354, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057904055","display_name":"Barbara J. Tarasevich","orcid":"https://orcid.org/0000-0001-9444-6836","observed_orcids":["https://orcid.org/0000-0001-9444-6836"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J. Tarasevich","raw_affiliation_strings":["Materials Sciences, Pacific Northwest National Laboratory, Richland, WA 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Sciences, Pacific Northwest National Laboratory, Richland, WA 99354, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038563335","display_name":"Joel G. Pounds","orcid":"https://orcid.org/0000-0002-6616-1566","observed_orcids":["https://orcid.org/0000-0002-6616-1566"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel G. Pounds","raw_affiliation_strings":["Biological Sciences, Pacific Northwest National Laboratory, Richland, WA 99354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, Pacific Northwest National Laboratory, Richland, WA 99354, USA","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015601396"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.0752,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.83861393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"236","issue":"2","first_page":"210","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.18880000710487366,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amorphous-silica-particles","display_name":"amorphous silica particles","score":0.9589999914169312},{"id":"https://openalex.org/keywords/positively-charged-particles","display_name":"positively charged particles","score":0.8399999737739563},{"id":"https://openalex.org/keywords/particle-internalization","display_name":"particle internalization","score":0.8899999856948853},{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/heparan-sulfate-proteoglycans","display_name":"heparan sulfate proteoglycans","score":0.9210000038146973},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/cell-particle-interactions","display_name":"particle-cell interactions","score":0.5920000076293945},{"id":"https://openalex.org/keywords/particle-toxicity","display_name":"particle toxicity","score":0.6819999814033508},{"id":"https://openalex.org/keywords/inhaled-particles","display_name":"inhaled particles","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.908358097076416},{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.7828371524810791},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.570904016494751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5678431987762451},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.5008504390716553},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.48422718048095703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47952842712402344},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.44653642177581787},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4139111042022705},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4075855314731598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18933600187301636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1880151331424713}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D052638","descriptor_name":"Particulate Matter","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053668","descriptor_name":"Syndecan-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.taap.2009.01.022","doi":"https://doi.org/10.1016/j.taap.2009.01.022","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.taap.2009.01.022","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:19371605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19371605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2919521460","display_name":null,"funder_award_id":"RD833338","funder_id":"https://openalex.org/F4320320835","funder_display_name":"Environmental Protection Agency"},{"id":"https://openalex.org/G3367698011","display_name":null,"funder_award_id":"FA8650\u201305\u20131\u20135041","funder_id":"https://openalex.org/F4320338294","funder_display_name":"Air Force Research Laboratory"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320312831","display_name":"Oregon Nanoscience and Microtechnologies Institute","ror":"https://ror.org/00hgwte81"},{"id":"https://openalex.org/F4320320835","display_name":"Environmental Protection Agency","ror":"https://ror.org/05qbqeh37"},{"id":"https://openalex.org/F4320338294","display_name":"Air Force Research Laboratory","ror":"https://ror.org/02e2egq70"},{"id":"https://openalex.org/F4320338354","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W96938930","https://openalex.org/W107992251","https://openalex.org/W1531891705","https://openalex.org/W1853807720","https://openalex.org/W1966976603","https://openalex.org/W1969349787","https://openalex.org/W1972171150","https://openalex.org/W1975833492","https://openalex.org/W1976109709","https://openalex.org/W1976811878","https://openalex.org/W1980290112","https://openalex.org/W1980450658","https://openalex.org/W1982965697","https://openalex.org/W1990309791","https://openalex.org/W1991089571","https://openalex.org/W1991172636","https://openalex.org/W1995464852","https://openalex.org/W1999460509","https://openalex.org/W1999468126","https://openalex.org/W2001038738","https://openalex.org/W2003336829","https://openalex.org/W2006188134","https://openalex.org/W2016600100","https://openalex.org/W2017615656","https://openalex.org/W2027008782","https://openalex.org/W2028035233","https://openalex.org/W2031143008","https://openalex.org/W2031506032","https://openalex.org/W2033960117","https://openalex.org/W2044044042","https://openalex.org/W2044179563","https://openalex.org/W2046890107","https://openalex.org/W2049624297","https://openalex.org/W2056978535","https://openalex.org/W2058246130","https://openalex.org/W2064311601","https://openalex.org/W2072879931","https://openalex.org/W2073355679","https://openalex.org/W2073475898","https://openalex.org/W2075051672","https://openalex.org/W2075105055","https://openalex.org/W2076382280","https://openalex.org/W2077576116","https://openalex.org/W2083618070","https://openalex.org/W2086069830","https://openalex.org/W2095734305","https://openalex.org/W2096096031","https://openalex.org/W2113860483","https://openalex.org/W2114950491","https://openalex.org/W2125240547","https://openalex.org/W2128942500","https://openalex.org/W2136462695","https://openalex.org/W2139960392","https://openalex.org/W2144588996","https://openalex.org/W2148230934","https://openalex.org/W2155118487","https://openalex.org/W2157489799","https://openalex.org/W2160957107","https://openalex.org/W2166395219","https://openalex.org/W2167806590","https://openalex.org/W2170208598","https://openalex.org/W2171263596","https://openalex.org/W2171627581","https://openalex.org/W2406225731","https://openalex.org/W6657212543"],"related_works":["https://openalex.org/W1980290112","https://openalex.org/W2807073074","https://openalex.org/W2049269927","https://openalex.org/W2002391544","https://openalex.org/W2056828473","https://openalex.org/W2128153968","https://openalex.org/W2315585663","https://openalex.org/W1931117608","https://openalex.org/W2193782895","https://openalex.org/W1996112060"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
