{"id":"https://openalex.org/W1963783377","doi":"https://doi.org/10.1002/jcb.20951","title":"Modified HMG\u2010CoA reductase and LDLr regulation is deeply involved in age\u2010related hypercholesterolemia","display_name":"Modified HMG\u2010CoA reductase and LDLr regulation is deeply involved in age\u2010related hypercholesterolemia","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W1963783377","doi":"https://doi.org/10.1002/jcb.20951","mag":"1963783377","pmid":"https://pubmed.ncbi.nlm.nih.gov/16741953"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.20951","doi":"https://doi.org/10.1002/jcb.20951","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.20951","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062446429","display_name":"Valentina Pallottini","orcid":"https://orcid.org/0000-0003-2511-6168","observed_orcids":["https://orcid.org/0000-0003-2511-6168"]},"institutions":[{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Valentina Pallottini","raw_affiliation_strings":["Department of Biology, University of Rome \"Roma Tre\", Viale Marconi 446, 00146 Rome, Italy. vpallott@uniroma3.it","Department of Biology, University of Rome ROMA TRE, Viale Marconi 446, 00146 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome \"Roma Tre\", Viale Marconi 446, 00146 Rome, Italy. vpallott@uniroma3.it","institution_ids":["https://openalex.org/I119003972"]},{"raw_affiliation_string":"Department of Biology, University of Rome ROMA TRE, Viale Marconi 446, 00146 Rome, Italy","institution_ids":["https://openalex.org/I119003972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091299641","display_name":"Chiara Martini","orcid":"https://orcid.org/0000-0002-0877-4954","observed_orcids":["https://orcid.org/0000-0002-0877-4954"]},"institutions":[{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Martini","raw_affiliation_strings":["Department of Biology, University of Rome \u201cRoma Tre\u201d, Viale Marconi, 446, 00146 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome \u201cRoma Tre\u201d, Viale Marconi, 446, 00146 Rome, Italy","institution_ids":["https://openalex.org/I119003972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031107244","display_name":"Gabriella Cavallini","orcid":"https://orcid.org/0000-0002-3734-6289","observed_orcids":["https://orcid.org/0000-0002-3734-6289"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Cavallini","raw_affiliation_strings":["Department of Experimental Pathology, University of Pisa, Via Roma, 8, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, University of Pisa, Via Roma, 8, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109165720","display_name":"Alessio Donati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Donati","raw_affiliation_strings":["Department of Experimental Pathology, University of Pisa, Via Roma, 8, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, University of Pisa, Via Roma, 8, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111378199","display_name":"Ettore Bergamini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore Bergamini","raw_affiliation_strings":["Department of Experimental Pathology, University of Pisa, Via Roma, 8, 56126 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, University of Pisa, Via Roma, 8, 56126 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081146160","display_name":"Maria Notarnicola","orcid":"https://orcid.org/0000-0003-2274-2198","observed_orcids":["https://orcid.org/0000-0003-2274-2198"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Notarnicola","raw_affiliation_strings":["I.R.C.C.S. \u201cDe Bellis\u201d Via della Resistenza, 70013 Castellana Grotte (BA), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.R.C.C.S. \u201cDe Bellis\u201d Via della Resistenza, 70013 Castellana Grotte (BA), Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079940936","display_name":"Maria Gabriella Caruso","orcid":"https://orcid.org/0000-0003-4518-6307","observed_orcids":["https://orcid.org/0000-0003-4518-6307"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Gabriella Caruso","raw_affiliation_strings":["I.R.C.C.S. \u201cDe Bellis\u201d Via della Resistenza, 70013 Castellana Grotte (BA), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I.R.C.C.S. \u201cDe Bellis\u201d Via della Resistenza, 70013 Castellana Grotte (BA), Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090490423","display_name":"Anna Trentalance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Trentalance","raw_affiliation_strings":["Department of Biology, University of Rome \u201cRoma Tre\u201d, Viale Marconi, 446, 00146 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome \u201cRoma Tre\u201d, Viale Marconi, 446, 00146 Rome, Italy","institution_ids":["https://openalex.org/I119003972"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062446429"],"corresponding_institution_ids":["https://openalex.org/I119003972"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":3.2424,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.90925089,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"98","issue":"5","first_page":"1044","last_page":"1053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sterol-regulatory-element-binding-proteins","display_name":"SREBP","score":0.8820000290870667},{"id":"https://openalex.org/keywords/srebp-2","display_name":"SREBP2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/scap","display_name":"SCAP","score":0.8830000162124634},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/enzyme-degradation","display_name":"enzyme degradation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.5609999895095825},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7480000257492065},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.7301474213600159},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.7089187502861023},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.6702041029930115},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.6050889492034912},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.5888131856918335},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5376296043395996},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5330454707145691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5068088173866272},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4440484046936035},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43949806690216064},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.43812185525894165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4219260513782501},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42049849033355713},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40148064494132996},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39630451798439026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35390913486480713},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.27688831090927124},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2737366557121277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2729615271091461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15917769074440002},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051779","descriptor_name":"Sterol Regulatory Element Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/jcb.20951","doi":"https://doi.org/10.1002/jcb.20951","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.20951","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:16741953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16741953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/199188","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/199188","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma3.it:11590/121057","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11590/121057","pdf_url":null,"source":{"id":"https://openalex.org/S4377196120","display_name":"Iris (Roma Tre University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119003972","host_organization_name":"Roma Tre University","host_organization_lineage":["https://openalex.org/I119003972"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W44263171","https://openalex.org/W1543816617","https://openalex.org/W1598401563","https://openalex.org/W1775749144","https://openalex.org/W1971942469","https://openalex.org/W1973397039","https://openalex.org/W1984026469","https://openalex.org/W1984505570","https://openalex.org/W2000352166","https://openalex.org/W2000815833","https://openalex.org/W2007711341","https://openalex.org/W2009616432","https://openalex.org/W2020353017","https://openalex.org/W2033293611","https://openalex.org/W2040641918","https://openalex.org/W2045472079","https://openalex.org/W2058614644","https://openalex.org/W2058743922","https://openalex.org/W2066981510","https://openalex.org/W2070509877","https://openalex.org/W2071124826","https://openalex.org/W2074997034","https://openalex.org/W2078081113","https://openalex.org/W2080664601","https://openalex.org/W2094535056","https://openalex.org/W2097632838","https://openalex.org/W2100482385","https://openalex.org/W2101973268","https://openalex.org/W2121936687","https://openalex.org/W2128963767","https://openalex.org/W2146544786","https://openalex.org/W2151602225","https://openalex.org/W2158157260","https://openalex.org/W2166890179","https://openalex.org/W2357597734","https://openalex.org/W2473956268","https://openalex.org/W4252021281"],"related_works":["https://openalex.org/W7002172689","https://openalex.org/W2053304248","https://openalex.org/W7020783604","https://openalex.org/W7008460598","https://openalex.org/W2109208578","https://openalex.org/W6982278567","https://openalex.org/W2015429953","https://openalex.org/W1977413660","https://openalex.org/W136583803","https://openalex.org/W1982296069"],"abstract_inverted_index":{"During":[0],"the":[1,21,36,81,84,87,90,95,100,102,159,164,167,194],"ageing":[2],"process":[3],"in":[4,8,44,67,173,179],"rats":[5,46],"hypercholesterolemia":[6],"occurs":[7],"concert":[9],"with":[10],"full":[11],"activation,":[12],"lowered":[13,41],"degradation":[14,42,61,161],"rate":[15,22,43,162],"and":[16,40,60,83,115,139,166],"an":[17],"unchanged":[18,38],"level":[19,39,85,103],"of":[20,35,62,72,80,86,89,94,104,123,163],"limiting":[23],"cholesterol":[24,96],"biosynthesis":[25],"enzyme,":[26],"3-hydroxy-3-methylglutaryl":[27],"coenzyme":[28],"A":[29],"reductase":[30],"(HMG-CoAR).":[31],"The":[32,121,146,171,185],"molecular":[33],"bases":[34],"HMG-CoAR":[37,165],"aged":[45],"is":[47,129,133],"not":[48],"clear.":[49],"In":[50],"fact":[51],"no":[52],"data":[53,187],"are":[54],"available":[55],"during":[56],"ageing,":[57],"on":[58],"transcription":[59,128],"HMG-CoAR,":[63],"so":[64],"well":[65],"defined":[66],"adult":[68],"animal.":[69],"So,":[70],"aim":[71],"this":[73],"work":[74],"was":[75],"to":[76,152,176,182,192],"measure":[77],"mRNA":[78],"levels":[79,122],"enzyme":[82],"proteins":[88,109],"regulatory":[91,106],"complex":[92],"responsible":[93],"metabolism.":[97],"To":[98],"complete":[99],"picture,":[101],"sterol":[105],"element":[107],"binding":[108],"(SREBPs),":[110],"SREBP":[111,130],"cleavage":[112],"activating":[113],"protein,":[114],"insulin-induced":[116],"gene":[117,183],"has":[118],"been":[119,143],"measured.":[120,145],"other":[124],"related":[125],"proteins,":[126],"whose":[127],"dependent,":[131],"that":[132],"low":[134],"density":[135],"lipoprotein":[136],"receptor":[137],"(LDLr)":[138],"Caveolin":[140],"1,":[141],"have":[142],"also":[144],"age-related":[147,195],"reduced":[148,154],"Insigs":[149],"levels,":[150],"joined":[151],"a":[153,189],"insulin":[155],"sensitivity,":[156],"could":[157],"explain":[158,193],"decreased":[160],"increased":[168],"active":[169],"SREBP-2.":[170],"SREBP-2":[172],"particular":[174],"seems":[175],"be":[177],"committed":[178],"multiple":[180],"way":[181],"transcription.":[184],"obtained":[186],"represent":[188],"good":[190],"contribution":[191],"hypercholesterolemia.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
