{"id":"https://openalex.org/W1963772620","doi":"https://doi.org/10.1007/s11064-013-1060-x","title":"Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases","display_name":"Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases","publication_year":2013,"publication_date":"2013-05-15","ids":{"openalex":"https://openalex.org/W1963772620","doi":"https://doi.org/10.1007/s11064-013-1060-x","mag":"1963772620","pmid":"https://pubmed.ncbi.nlm.nih.gov/23677775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3691476"},"language":"en","primary_location":{"id":"doi:10.1007/s11064-013-1060-x","doi":"https://doi.org/10.1007/s11064-013-1060-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11064-013-1060-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1060-x.pdf","source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1060-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053513783","display_name":"Andrzej Szutowicz","orcid":"https://orcid.org/0000-0002-3723-2097","observed_orcids":["https://orcid.org/0000-0002-3723-2097"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Andrzej Szutowicz","raw_affiliation_strings":["Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland. aszut@gumed.edu.pl","Medical University of Gda\u00f1sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland. aszut@gumed.edu.pl","institution_ids":["https://openalex.org/I75124487"]},{"raw_affiliation_string":"Medical University of Gda\u00f1sk","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017720496","display_name":"Hanna Bielarczyk","orcid":"https://orcid.org/0000-0002-5956-4498","observed_orcids":["https://orcid.org/0000-0002-5956-4498"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Hanna Bielarczyk","raw_affiliation_strings":["Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland","Medical University of Gda\u00f1sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]},{"raw_affiliation_string":"Medical University of Gda\u00f1sk","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608980","display_name":"Agnieszka Jankowska-Kulawy","orcid":"https://orcid.org/0000-0003-2753-2763","observed_orcids":["https://orcid.org/0000-0003-2753-2763"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agnieszka Jankowska-Kulawy","raw_affiliation_strings":["Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland","Medical University of Gda\u00f1sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]},{"raw_affiliation_string":"Medical University of Gda\u00f1sk","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072250438","display_name":"Tadeusz Pawe\u0142czyk","orcid":"https://orcid.org/0000-0002-0375-732X","observed_orcids":["https://orcid.org/0000-0002-0375-732X"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tadeusz Pawe\u0142czyk","raw_affiliation_strings":["Department of Molecular Medicine, Medical University of Gda\u0144sk, Gda\u0144sk, Poland","Medical University of Gda\u00f1sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Medical University of Gda\u0144sk, Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]},{"raw_affiliation_string":"Medical University of Gda\u00f1sk","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033349763","display_name":"Anna Ronowska","orcid":"https://orcid.org/0000-0001-5715-1211","observed_orcids":["https://orcid.org/0000-0001-5715-1211"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Ronowska","raw_affiliation_strings":["Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland","Medical University of Gda\u00f1sk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Medical University of Gda\u0144sk, Ul. D\u0119binki 7, 80-211, Gda\u0144sk, Poland","institution_ids":["https://openalex.org/I75124487"]},{"raw_affiliation_string":"Medical University of Gda\u00f1sk","institution_ids":["https://openalex.org/I75124487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053513783"],"corresponding_institution_ids":["https://openalex.org/I75124487"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.8762,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.60650888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"8","first_page":"1523","last_page":"1542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06350000202655792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-complex","display_name":"pyruvate dehydrogenase complex","score":0.9309999942779541},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8989999890327454},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/acetylcholine-synthesis","display_name":"acetylcholine synthesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.7360000014305115},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.6311359405517578},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6194245219230652},{"id":"https://openalex.org/C39920043","wikidata":"https://www.wikidata.org/wiki/Q786278","display_name":"Neurochemistry","level":3,"score":0.607372522354126},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5011124610900879},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.44944337010383606},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.4420498013496399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40116992592811584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33211639523506165},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000105","descriptor_name":"Acetyl Coenzyme A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s11064-013-1060-x","doi":"https://doi.org/10.1007/s11064-013-1060-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11064-013-1060-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1060-x.pdf","source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2685711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3691476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23677775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23677775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3691476","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3691476/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochem Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.2361","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.2361","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/82/20/11064_2013_Article_1060.PMC3691476.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s11064-013-1060-x","doi":"https://doi.org/10.1007/s11064-013-1060-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11064-013-1060-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1060-x.pdf","source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322733","display_name":"Ministerstwo Edukacji i Nauki","ror":"https://ror.org/05dwvd537"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963772620.pdf","grobid_xml":"https://content.openalex.org/works/W1963772620.grobid-xml"},"referenced_works_count":188,"referenced_works":["https://openalex.org/W4238906","https://openalex.org/W68463649","https://openalex.org/W146519451","https://openalex.org/W268901812","https://openalex.org/W1501555066","https://openalex.org/W1509238502","https://openalex.org/W1515288366","https://openalex.org/W1525738413","https://openalex.org/W1544740422","https://openalex.org/W1551151660","https://openalex.org/W1559324825","https://openalex.org/W1581850992","https://openalex.org/W1605885548","https://openalex.org/W1625071251","https://openalex.org/W1645403146","https://openalex.org/W1673416974","https://openalex.org/W1681064839","https://openalex.org/W1779682141","https://openalex.org/W1802455527","https://openalex.org/W1886575365","https://openalex.org/W1928313261","https://openalex.org/W1963805458","https://openalex.org/W1965107086","https://openalex.org/W1965842048","https://openalex.org/W1966645595","https://openalex.org/W1967253192","https://openalex.org/W1969231637","https://openalex.org/W1970431048","https://openalex.org/W1971783082","https://openalex.org/W1972525575","https://openalex.org/W1972850922","https://openalex.org/W1976861183","https://openalex.org/W1977622464","https://openalex.org/W1979094225","https://openalex.org/W1979183551","https://openalex.org/W1979742224","https://openalex.org/W1979829753","https://openalex.org/W1980164623","https://openalex.org/W1980883732","https://openalex.org/W1981166958","https://openalex.org/W1981200556","https://openalex.org/W1981368778","https://openalex.org/W1981458288","https://openalex.org/W1983746043","https://openalex.org/W1984412958","https://openalex.org/W1985292661","https://openalex.org/W1986298163","https://openalex.org/W1988576735","https://openalex.org/W1988843930","https://openalex.org/W1989407221","https://openalex.org/W1991968136","https://openalex.org/W1993692534","https://openalex.org/W1994771726","https://openalex.org/W1996494449","https://openalex.org/W1997661796","https://openalex.org/W1998036938","https://openalex.org/W1999591907","https://openalex.org/W2000706612","https://openalex.org/W2001066986","https://openalex.org/W2005503052","https://openalex.org/W2008203844","https://openalex.org/W2008861534","https://openalex.org/W2009759484","https://openalex.org/W2010187525","https://openalex.org/W2011746987","https://openalex.org/W2011969090","https://openalex.org/W2012617759","https://openalex.org/W2012621449","https://openalex.org/W2013256363","https://openalex.org/W2013770936","https://openalex.org/W2015582271","https://openalex.org/W2017079501","https://openalex.org/W2019657620","https://openalex.org/W2020061548","https://openalex.org/W2021014339","https://openalex.org/W2021346090","https://openalex.org/W2022483350","https://openalex.org/W2023411795","https://openalex.org/W2026816538","https://openalex.org/W2027061069","https://openalex.org/W2028320321","https://openalex.org/W2028384515","https://openalex.org/W2031942380","https://openalex.org/W2032163981","https://openalex.org/W2033508630","https://openalex.org/W2033658395","https://openalex.org/W2034615358","https://openalex.org/W2035290496","https://openalex.org/W2036839645","https://openalex.org/W2040869151","https://openalex.org/W2043053390","https://openalex.org/W2044385925","https://openalex.org/W2046858517","https://openalex.org/W2049449180","https://openalex.org/W2050215864","https://openalex.org/W2051303822","https://openalex.org/W2052915752","https://openalex.org/W2053758857","https://openalex.org/W2053924529","https://openalex.org/W2054294333","https://openalex.org/W2054742331","https://openalex.org/W2058096429","https://openalex.org/W2058121276","https://openalex.org/W2058425661","https://openalex.org/W2059721162","https://openalex.org/W2060893933","https://openalex.org/W2062644904","https://openalex.org/W2062706679","https://openalex.org/W2063932219","https://openalex.org/W2064111465","https://openalex.org/W2064540971","https://openalex.org/W2065191501","https://openalex.org/W2067963805","https://openalex.org/W2068678697","https://openalex.org/W2068997428","https://openalex.org/W2069303994","https://openalex.org/W2072509079","https://openalex.org/W2073086859","https://openalex.org/W2073285446","https://openalex.org/W2074092374","https://openalex.org/W2074395614","https://openalex.org/W2074468913","https://openalex.org/W2074874295","https://openalex.org/W2075788414","https://openalex.org/W2076059045","https://openalex.org/W2077113902","https://openalex.org/W2077705158","https://openalex.org/W2079625146","https://openalex.org/W2080147613","https://openalex.org/W2080225612","https://openalex.org/W2080323442","https://openalex.org/W2081869280","https://openalex.org/W2082235350","https://openalex.org/W2082766755","https://openalex.org/W2083317764","https://openalex.org/W2084785765","https://openalex.org/W2086253463","https://openalex.org/W2087255758","https://openalex.org/W2090091665","https://openalex.org/W2090828039","https://openalex.org/W2091391741","https://openalex.org/W2092146469","https://openalex.org/W2092548955","https://openalex.org/W2094767283","https://openalex.org/W2101672833","https://openalex.org/W2102545959","https://openalex.org/W2104128198","https://openalex.org/W2106093262","https://openalex.org/W2107013935","https://openalex.org/W2109068739","https://openalex.org/W2111516110","https://openalex.org/W2112357968","https://openalex.org/W2113402112","https://openalex.org/W2115889677","https://openalex.org/W2117120039","https://openalex.org/W2119983609","https://openalex.org/W2121028686","https://openalex.org/W2127150445","https://openalex.org/W2128578138","https://openalex.org/W2136742948","https://openalex.org/W2137466165","https://openalex.org/W2137777161","https://openalex.org/W2138648425","https://openalex.org/W2144575277","https://openalex.org/W2146455514","https://openalex.org/W2148105857","https://openalex.org/W2149168676","https://openalex.org/W2152165298","https://openalex.org/W2152299618","https://openalex.org/W2152420555","https://openalex.org/W2155714885","https://openalex.org/W2158606960","https://openalex.org/W2159359957","https://openalex.org/W2162846333","https://openalex.org/W2166070786","https://openalex.org/W2168035874","https://openalex.org/W2168534798","https://openalex.org/W2174634321","https://openalex.org/W2228108424","https://openalex.org/W2344015391","https://openalex.org/W2395290096","https://openalex.org/W2409653942","https://openalex.org/W2431103296","https://openalex.org/W2467818932","https://openalex.org/W2477848304","https://openalex.org/W2479413981","https://openalex.org/W2502914033","https://openalex.org/W4413980012"],"related_works":["https://openalex.org/W7100510726","https://openalex.org/W2089388064","https://openalex.org/W1979742224","https://openalex.org/W2015582271","https://openalex.org/W2080147613","https://openalex.org/W2284840464","https://openalex.org/W2579442274","https://openalex.org/W7221602512","https://openalex.org/W1979183551","https://openalex.org/W2058121276"],"abstract_inverted_index":{"Glucose-derived":[0],"pyruvate":[1,13],"is":[2,78],"a":[3],"principal":[4],"source":[5],"of":[6,22,50,66,81,90,145,155,177],"acetyl-CoA":[7,30,51,96,146,178],"in":[8,34,40,55,101,105,116,147,172,180],"all":[9],"brain":[10],"cells,":[11,28,110],"through":[12,175],"dehydogenase":[14],"complex":[15],"(PDHC)":[16],"reaction.":[17],"Cholinergic":[18],"neurons":[19,21,46,103,133,157],"like":[20],"other":[23],"transmitter":[24,62,118],"systems":[25],"and":[26,36,73,88,108],"glial":[27,109],"utilize":[29],"for":[31,52,130,135],"energy":[32],"production":[33],"mitochondria":[35],"diverse":[37,159],"synthetic":[38],"pathways":[39],"their":[41,56,61],"extramitochondrial":[42],"compartments.":[43],"However,":[44],"cholinergic":[45,86,102,132,156,173,182],"require":[47],"additional":[48,114],"amounts":[49],"acetylcholine":[53],"synthesis":[54],"cytoplasmic":[57],"compartment":[58],"to":[59,112,126,158],"maintain":[60],"functions.":[63,92],"Characteristic":[64],"feature":[65],"several":[67],"neurodegenerating":[68],"diseases":[69],"including":[70],"Alzheimer's":[71],"disease":[72],"thiamine":[74],"diphosphate":[75],"deficiency":[76],"encephalopathy":[77],"the":[79,117,131,148,181],"decrease":[80],"PDHC":[82],"activity":[83],"correlating":[84],"with":[85],"deficits":[87,97],"losses":[89],"cognitive":[91],"Such":[93],"conditions":[94,123],"generate":[95],"that":[98],"are":[99,124],"deeper":[100],"than":[104,134],"noncholinergic":[106,136],"neuronal":[107],"due":[111],"its":[113],"consumption":[115],"synthesis.":[119],"Therefore,":[120],"any":[121],"neuropathologic":[122],"likely":[125],"be":[127],"more":[128],"harmful":[129],"ones.":[137],"For":[138],"this":[139],"reason":[140],"attempts":[141],"preserving":[142],"proper":[143],"supply":[144],"diseased":[149],"brain,":[150],"should":[151],"attenuate":[152],"high":[153],"susceptibility":[154],"neurodegenerative":[160,167],"conditions.":[161],"This":[162],"review":[163],"describes":[164],"how":[165],"common":[166],"signals":[168],"could":[169],"induce":[170],"deficts":[171],"neurotransmission":[174],"suppression":[176],"metabolism":[179],"neurons.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}