{"id":"https://openalex.org/W1963726922","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","title":"5-AZA-2?-deoxycytidine-induced dysmorphogenesis in the rat","display_name":"5-AZA-2?-deoxycytidine-induced dysmorphogenesis in the rat","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1963726922","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","mag":"1963726922","pmid":"https://pubmed.ncbi.nlm.nih.gov/10495450"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","pdf_url":null,"source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015088296","display_name":"Stacy Branch","orcid":"https://orcid.org/0000-0002-1048-6097","observed_orcids":["https://orcid.org/0000-0002-1048-6097"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Branch","raw_affiliation_strings":["Department of Toxicology, North Carolina State University, Raleigh, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, North Carolina State University, Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025952841","display_name":"Neil Chernoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Chernoff","raw_affiliation_strings":["United States Environmental Protection Agency, NHEERL, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Environmental Protection Agency, NHEERL, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113468863","display_name":"Cecil F. Brownie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Brownie","raw_affiliation_strings":["Statistics Department, North Carolina State University, Raleigh, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics Department, North Carolina State University, Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113942573","display_name":"B. Magnus Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Magnus Francis","raw_affiliation_strings":["Department of Entomology, University of Illinois, Urbana, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomology, University of Illinois, Urbana, Illinois","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015088296"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"19","issue":"5","first_page":"329","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.996999979019165},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dysmorphogenesis","display_name":"dysmorphogenesis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/phocomelia","display_name":"phocomelia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cleft-palate","display_name":"cleft palate","score":0.8949999809265137},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7450000047683716},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.35499998927116394},{"id":"https://openalex.org/keywords/rat-embryo","display_name":"rat embryo","score":0.4259999990463257},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2778646069","wikidata":"https://www.wikidata.org/wiki/Q5468632","display_name":"Forelimb","level":2,"score":0.9540706276893616},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.8278721570968628},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.7376170754432678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6347224116325378},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.45242512226104736},{"id":"https://openalex.org/C2777971045","wikidata":"https://www.wikidata.org/wiki/Q1377526","display_name":"Axial skeleton","level":2,"score":0.45108234882354736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4338959753513336},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.41838985681533813},{"id":"https://openalex.org/C2777844706","wikidata":"https://www.wikidata.org/wiki/Q422504","display_name":"Deoxycytidine","level":4,"score":0.41700899600982666},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3856050968170166},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3454616665840149},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26636120676994324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19057762622833252},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10211679339408875},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08715838193893433},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D004480","descriptor_name":"Ectromelia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020567","descriptor_name":"Fetal Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.0.co;2-s","pdf_url":null,"source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.3.co;2-j","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.3.co;2-j","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.3.co;2-j","pdf_url":null,"source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},{"id":"pmid:10495450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10495450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, carcinogenesis, and mutagenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320310013","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1905627141","https://openalex.org/W1964529816","https://openalex.org/W1965378320","https://openalex.org/W1973918069","https://openalex.org/W1974605049","https://openalex.org/W1991069657","https://openalex.org/W1991564573","https://openalex.org/W1991904488","https://openalex.org/W1994654396","https://openalex.org/W2015098675","https://openalex.org/W2042190289","https://openalex.org/W2046241907","https://openalex.org/W2059559334","https://openalex.org/W2065767835","https://openalex.org/W2099407461","https://openalex.org/W2141720311","https://openalex.org/W7014527517"],"related_works":["https://openalex.org/W1973918069","https://openalex.org/W2062685638","https://openalex.org/W2141720311","https://openalex.org/W1964529816","https://openalex.org/W2130623407","https://openalex.org/W2349748995","https://openalex.org/W2559512764","https://openalex.org/W1965378320","https://openalex.org/W2119570595","https://openalex.org/W2059840007"],"abstract_inverted_index":{"5-aza-2'-deoxycytidine":[0],"(d-AZA)":[1],"causes":[2],"temporally":[3],"related":[4],"defects":[5,154],"in":[6,20,46,132,182,199,206,218],"the":[7,50,57,60,77,83,117,130,133,138,183,189,192,200,209,219,227,232,237],"developing":[8],"mouse.":[9,118,139],"Treatment":[10],"of":[11,43,67,80,116,151,162,188,203,212,226],"1.0":[12],"mg/kg":[13],"on":[14,24,31,36,106],"gestation":[15],"day":[16],"(GD)":[17],"8":[18],"results":[19],"axial":[21,152],"skeletal":[22,153],"defects;":[23,30],"GD9,":[25,107],"cleft":[26,156],"palate":[27],"and":[28,35,59,155,165,168,173,191],"vertebral":[29],"GD10,":[32,147],"hindlimb":[33,171],"phocomelia;":[34],"GD11,":[37,158],"digital":[38],"defects.":[39,176],"An":[40],"unusual":[41],"aspect":[42],"d-AZA":[44,97,187],"teratogenicity":[45],"mice":[47],"is":[48,62],"that":[49,225],"phocomelia":[51,164,172],"appears":[52],"to":[53,56,75,85,112,129,137,186,224,229],"be":[54,222],"specific":[55],"hindlimb,":[58],"forelimb":[61,163,174],"not":[63],"similarly":[64],"affected":[65],"regardless":[66],"treatment":[68,141],"day.":[69],"The":[70,101,119],"current":[71],"study":[72],"was":[73,103,142],"initiated":[74],"evaluate":[76],"embryonic":[78],"response":[79],"another":[81],"species,":[82],"rat,":[84],"this":[86],"unique":[87],"teratogen.":[88],"Pregnant":[89],"Sprague":[90],"Dawley":[91],"(CD)":[92],"rats":[93],"were":[94],"treated":[95],"with":[96],"or":[98,110],"vehicle":[99],"control.":[100],"compound":[102,131],"administered":[104],"i.p.":[105],"10,":[108],"11,":[109],"12":[111],"parallel":[113],"developmental":[114,184,233],"staging":[115],"highest":[120],"dose":[121],"(1.0":[122],"mg/kg)":[123],"elicited":[124],"effects":[125],"indicating":[126],"increased":[127],"sensitivity":[128],"rat":[134,228],"as":[135],"compared":[136,223],"GD9":[140],"characterized":[143],"by":[144,148,159,170],"massive":[145],"resorptions;":[146],"a":[149,160],"predominance":[150,161],"palate;":[157],"missing":[166],"ribs;":[167],"GD12":[169],"digit":[175],"These":[177],"data":[178,216],"indicate":[179],"significant":[180],"differences":[181,198],"responses":[185],"mouse":[190,220],"rat.":[193],"This":[194],"may":[195],"reflect":[196],"interspecies":[197,238],"temporal":[201],"expression":[202],"genes":[204],"involved":[205],"morphogenesis":[207],"and/or":[208],"methylation":[210],"patterns":[211],"such":[213],"genes.":[214],"Molecular":[215],"generated":[217],"will":[221],"further":[230],"characterize":[231],"dynamics":[234],"responsible":[235],"for":[236],"differences.":[239],"Teratogenesis":[240],"Carcinog.":[241],"Mutagen.":[242],"19:329-338,":[243],"1999.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
