{"id":"https://openalex.org/W1963705072","doi":"https://doi.org/10.1038/sj.onc.1202143","title":"CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells","display_name":"CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells","publication_year":1998,"publication_date":"1998-10-29","ids":{"openalex":"https://openalex.org/W1963705072","doi":"https://doi.org/10.1038/sj.onc.1202143","mag":"1963705072","pmid":"https://pubmed.ncbi.nlm.nih.gov/9811457"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1202143","doi":"https://doi.org/10.1038/sj.onc.1202143","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1202143","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102494009","display_name":"Ritsu Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ritsu Suzuki","raw_affiliation_strings":["Institute of Life Science, Kurume University, Japan","Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Japan","institution_ids":["https://openalex.org/I105296287"]},{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Sakamoto","raw_affiliation_strings":["Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000373816","display_name":"Hideo Yasukawa","orcid":"https://orcid.org/0000-0003-0422-1145","observed_orcids":["https://orcid.org/0000-0003-0422-1145"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Yasukawa","raw_affiliation_strings":["Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","Third Department of Internal Medicine, Faculty of Medicine, Kurume University, Asahi-machi, Kurume, 830-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]},{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, Kurume University, Asahi-machi, Kurume, 830-0011, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036680398","display_name":"Masaaki Masuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Masuhara","raw_affiliation_strings":["Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071397970","display_name":"Toru Wakioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Wakioka","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kurume University, Asahi-machi, Kurume, 830-0011, Japan","Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kurume University, Asahi-machi, Kurume, 830-0011, Japan","institution_ids":["https://openalex.org/I105296287"]},{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086206547","display_name":"Atsuo T. Sasaki","orcid":"https://orcid.org/0000-0003-2963-4501","observed_orcids":["https://orcid.org/0000-0003-2963-4501"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuo Sasaki","raw_affiliation_strings":["Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040567454","display_name":"Kentaro Yuge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Yuge","raw_affiliation_strings":["Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127800","display_name":"Setsuro Komiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Setsuro Komiya","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kurume University, Asahi-machi, Kurume, 830-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kurume University, Asahi-machi, Kurume, 830-0011, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akio Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Inoue","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kurume University, Asahi-machi, Kurume, 830-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kurume University, Asahi-machi, Kurume, 830-0011, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031427780","display_name":"Akihiko Yoshimura","orcid":"https://orcid.org/0000-0001-5676-8949","observed_orcids":["https://orcid.org/0000-0001-5676-8949","https://orcid.org/0000-0002-8038-1717"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Yoshimura","raw_affiliation_strings":["Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume, 839-0861, Japan","institution_ids":["https://openalex.org/I105296287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I105296287"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":4.9239,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.96070766,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"17","issue":"17","first_page":"2271","last_page":"2278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jab","display_name":"jab","score":0.8889999985694885},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8059999942779541},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.8679999709129333},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fc-gamma-receptor-i","display_name":"Fc gamma receptor I","score":0.9350000023841858},{"id":"https://openalex.org/keywords/jak2-tyrosine-kinase","display_name":"JAK2 tyrosine kinase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7501494884490967},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6170345544815063},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5927319526672363},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5523169040679932},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.438143253326416},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.43251392245292664},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41569364070892334},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.412632554769516},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4029892385005951},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21140414476394653}],"mesh":[{"descriptor_ui":"D000071222","descriptor_name":"Suppressor of Cytokine Signaling 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071223","descriptor_name":"Suppressor of Cytokine Signaling 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053605","descriptor_name":"Leukemia Inhibitory Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.onc.1202143","doi":"https://doi.org/10.1038/sj.onc.1202143","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1202143","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:9811457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9811457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2293199762","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000342893","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309785","display_name":"Naito Foundation","ror":"https://ror.org/02s016q17"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137145530","https://openalex.org/W2315205838","https://openalex.org/W2150176853","https://openalex.org/W2008295144","https://openalex.org/W2042218061","https://openalex.org/W1487582551","https://openalex.org/W2330036938","https://openalex.org/W2657159767","https://openalex.org/W1968990190","https://openalex.org/W2155449991"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}