{"id":"https://openalex.org/W1963675451","doi":"https://doi.org/10.1016/j.drudis.2006.03.001","title":"Antibacterial drug discovery and structure-based design","display_name":"Antibacterial drug discovery and structure-based design","publication_year":2006,"publication_date":"2006-04-23","ids":{"openalex":"https://openalex.org/W1963675451","doi":"https://doi.org/10.1016/j.drudis.2006.03.001","mag":"1963675451","pmid":"https://pubmed.ncbi.nlm.nih.gov/16635801"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2006.03.001","doi":"https://doi.org/10.1016/j.drudis.2006.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2006.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103439885","display_name":"John J. Barker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148098","display_name":"Evotec (United Kingdom)","ror":"https://ror.org/04qvy9k41","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210130816","https://openalex.org/I4210148098"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John J. Barker","raw_affiliation_strings":["Evotec UK, 111 Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK. john.barker@evotec.com","Evotec UK, 111 Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec UK, 111 Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK. john.barker@evotec.com","institution_ids":["https://openalex.org/I4210148098"]},{"raw_affiliation_string":"Evotec UK, 111 Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK","institution_ids":["https://openalex.org/I4210148098"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103439885"],"corresponding_institution_ids":["https://openalex.org/I4210148098"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":null,"fwci":0.6517,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.50980392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"11","issue":"9-10","first_page":"391","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-discovery","display_name":"antibiotic discovery","score":0.972000002861023},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bacterial-resistance","display_name":"bacterial resistance","score":0.7319999933242798},{"id":"https://openalex.org/keywords/antibiotic-targets","display_name":"antibiotic targets","score":0.7630000114440918},{"id":"https://openalex.org/keywords/new-antibiotics","display_name":"novel antibiotics","score":0.6060000061988831},{"id":"https://openalex.org/keywords/antibiotic-pipeline","display_name":"antibiotic pipeline","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7177411913871765},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.5617949962615967},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5570851564407349},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44655951857566833},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39055415987968445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3293902575969696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30173203349113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2047206163406372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07843378186225891}],"mesh":[{"descriptor_ui":"D000069349","descriptor_name":"Linezolid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023303","descriptor_name":"Oxazolidinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.drudis.2006.03.001","doi":"https://doi.org/10.1016/j.drudis.2006.03.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2006.03.001","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:16635801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16635801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W43163001","https://openalex.org/W196894692","https://openalex.org/W1520268322","https://openalex.org/W1553345136","https://openalex.org/W1592698292","https://openalex.org/W1601335235","https://openalex.org/W1728871043","https://openalex.org/W1900949922","https://openalex.org/W1918498545","https://openalex.org/W1964619751","https://openalex.org/W1964841429","https://openalex.org/W1965866496","https://openalex.org/W1966103442","https://openalex.org/W1967189967","https://openalex.org/W1969435224","https://openalex.org/W1971551011","https://openalex.org/W1975361143","https://openalex.org/W1975447903","https://openalex.org/W1975806050","https://openalex.org/W1977071520","https://openalex.org/W1977444198","https://openalex.org/W1978378674","https://openalex.org/W1981076832","https://openalex.org/W1982662224","https://openalex.org/W1983296406","https://openalex.org/W1983611229","https://openalex.org/W1983788552","https://openalex.org/W1984454747","https://openalex.org/W1986240377","https://openalex.org/W1987641460","https://openalex.org/W1989380134","https://openalex.org/W1990186735","https://openalex.org/W1995003178","https://openalex.org/W1996135614","https://openalex.org/W1998933192","https://openalex.org/W2003765170","https://openalex.org/W2005170733","https://openalex.org/W2006373999","https://openalex.org/W2008232775","https://openalex.org/W2010087271","https://openalex.org/W2012631644","https://openalex.org/W2012686105","https://openalex.org/W2014739829","https://openalex.org/W2014989916","https://openalex.org/W2015820373","https://openalex.org/W2016240055","https://openalex.org/W2016296087","https://openalex.org/W2017662055","https://openalex.org/W2017800476","https://openalex.org/W2019109910","https://openalex.org/W2019567686","https://openalex.org/W2026355982","https://openalex.org/W2027214692","https://openalex.org/W2027246104","https://openalex.org/W2027801033","https://openalex.org/W2030410219","https://openalex.org/W2031364460","https://openalex.org/W2038271205","https://openalex.org/W2040255633","https://openalex.org/W2040293762","https://openalex.org/W2041686943","https://openalex.org/W2042383469","https://openalex.org/W2044337867","https://openalex.org/W2045679602","https://openalex.org/W2045801059","https://openalex.org/W2047118695","https://openalex.org/W2048214699","https://openalex.org/W2049259261","https://openalex.org/W2049617418","https://openalex.org/W2051038130","https://openalex.org/W2051592117","https://openalex.org/W2054342607","https://openalex.org/W2054354711","https://openalex.org/W2054411861","https://openalex.org/W2062291001","https://openalex.org/W2063098602","https://openalex.org/W2065884817","https://openalex.org/W2067484324","https://openalex.org/W2067677115","https://openalex.org/W2070196678","https://openalex.org/W2072256706","https://openalex.org/W2074785621","https://openalex.org/W2074978477","https://openalex.org/W2075186867","https://openalex.org/W2075964433","https://openalex.org/W2078048835","https://openalex.org/W2079865160","https://openalex.org/W2081027015","https://openalex.org/W2084344997","https://openalex.org/W2085162369","https://openalex.org/W2089136101","https://openalex.org/W2089656772","https://openalex.org/W2092630918","https://openalex.org/W2092763509","https://openalex.org/W2094303590","https://openalex.org/W2096942328","https://openalex.org/W2097977801","https://openalex.org/W2098627421","https://openalex.org/W2098807280","https://openalex.org/W2099384461","https://openalex.org/W2101355256","https://openalex.org/W2101685360","https://openalex.org/W2104075210","https://openalex.org/W2105069516","https://openalex.org/W2106177696","https://openalex.org/W2106192857","https://openalex.org/W2107870109","https://openalex.org/W2113318738","https://openalex.org/W2114254991","https://openalex.org/W2119378770","https://openalex.org/W2120291672","https://openalex.org/W2121303975","https://openalex.org/W2121915984","https://openalex.org/W2123117050","https://openalex.org/W2124148699","https://openalex.org/W2125777370","https://openalex.org/W2126221698","https://openalex.org/W2126809195","https://openalex.org/W2127295844","https://openalex.org/W2127658176","https://openalex.org/W2128780278","https://openalex.org/W2129832229","https://openalex.org/W2132175878","https://openalex.org/W2132600317","https://openalex.org/W2142826460","https://openalex.org/W2143641256","https://openalex.org/W2145513267","https://openalex.org/W2147241123","https://openalex.org/W2152173135","https://openalex.org/W2153848674","https://openalex.org/W2158815676","https://openalex.org/W2162511624","https://openalex.org/W2163864714","https://openalex.org/W2168778762","https://openalex.org/W2170243611","https://openalex.org/W2170344031","https://openalex.org/W2172578489","https://openalex.org/W2172867693","https://openalex.org/W2176028587","https://openalex.org/W2178649408","https://openalex.org/W2179461628","https://openalex.org/W2276374504","https://openalex.org/W2318777851","https://openalex.org/W2414693816","https://openalex.org/W2420555659","https://openalex.org/W4211254771","https://openalex.org/W4246516957","https://openalex.org/W6699853505"],"related_works":["https://openalex.org/W2146641929","https://openalex.org/W1997663081","https://openalex.org/W2094613507","https://openalex.org/W169349371","https://openalex.org/W2092620764","https://openalex.org/W2073507989","https://openalex.org/W2335535405","https://openalex.org/W2914631090","https://openalex.org/W2069886797","https://openalex.org/W1945141992"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
