{"id":"https://openalex.org/W1963660637","doi":"https://doi.org/10.1016/s0002-9149(96)00353-0","title":"Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction","display_name":"Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W1963660637","doi":"https://doi.org/10.1016/s0002-9149(96)00353-0","mag":"1963660637","pmid":"https://pubmed.ncbi.nlm.nih.gov/8806332"},"language":"en","primary_location":{"id":"doi:10.1016/s0002-9149(96)00353-0","doi":"https://doi.org/10.1016/s0002-9149(96)00353-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","pdf_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","source":{"id":"https://openalex.org/S185186944","display_name":"The American Journal of Cardiology","issn_l":"0002-9149","issn":["0002-9149","1879-1913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035334697","display_name":"Jonathan Scharfstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Scharfstein","raw_affiliation_strings":["Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041079260","display_name":"Dana R. Abendschein","orcid":"https://orcid.org/0000-0001-6640-9958","observed_orcids":["https://orcid.org/0000-0001-6640-9958"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana R. Abendschein","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107309625","display_name":"Paul R. Eisenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R. Eisenberg","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109935481","display_name":"Dorinda George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorinda George","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026602252","display_name":"Christopher Paul Cannon","orcid":"https://orcid.org/0000-0003-4596-2791","observed_orcids":["https://orcid.org/0000-0003-4596-2791"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Cannon","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004956623","display_name":"Richard Clinton Becker","orcid":"https://orcid.org/0000-0002-9878-7707","observed_orcids":["https://orcid.org/0000-0002-9878-7707"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C. Becker","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112384262","display_name":"Burton E. Sobel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Burton Sobel","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059560495","display_name":"L. Adrienne Cupples","orcid":"https://orcid.org/0000-0003-0273-7965","observed_orcids":["https://orcid.org/0000-0003-0273-7965"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.Adrienne Cupples","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267024","display_name":"Eugene Braunwald","orcid":"https://orcid.org/0000-0002-3472-626X","observed_orcids":["https://orcid.org/0000-0002-3472-626X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Braunwald","raw_affiliation_strings":["From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","Investigators","18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine , Boston University School of Medicine , Boston , Mossachu - setts; the","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Investigators","institution_ids":[]},{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028396638","display_name":"Joseph Loscalzo","orcid":"https://orcid.org/0000-0002-1153-8047","observed_orcids":["https://orcid.org/0000-0002-1153-8047"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Loscalzo","raw_affiliation_strings":["18. 01996 by Excerpt0 Medico, Inc","Boston University School of Public Health, Boston, Massachusetts","Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","Department of Medicine, Washington University School of Medicine, St. Louis,","From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"18. 01996 by Excerpt0 Medico, Inc","institution_ids":[]},{"raw_affiliation_string":"Boston University School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; the","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, University of Vermont College of Med-icine, Burlington, Vermont; and","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis,","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mossachu-setts; the Department of Medicine,","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Mis-souri; Thrombosis Research Center and Department of Medicine, Uni-versity of Massachusetts Medical Center, Worcester, Massachusetis; the","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Sec-tion, Evans Department of Medicine, Boston University Medica Y Cen-ter Hospital, 88 East Newton Street, Boston, MA 02","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109927974","display_name":"The TIMI III Investigators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"The TIMI- Investigators","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":{"value":3380,"currency":"USD","value_usd":3380},"fwci":6.7274,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97164326,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"78","issue":"5","first_page":"503","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.17299999296665192,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fibrinopeptide-a","display_name":"fibrinopeptide A","score":0.9079999923706055},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9660000205039978},{"id":"https://openalex.org/keywords/prothrombin-fragment-1-2","display_name":"prothrombin fragment 1+2","score":0.996999979019165},{"id":"https://openalex.org/keywords/procoagulant-activity","display_name":"procoagulant activity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hirudin","display_name":"hirudin","score":0.7070000171661377},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.902999997138977},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.6029999852180481},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.7770000100135803},{"id":"https://openalex.org/keywords/recurrent-ischemia","display_name":"recurrent ischemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4819999933242798},{"id":"https://openalex.org/keywords/timi-flow-grade","display_name":"TIMI flow","score":0.6110000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9321658611297607},{"id":"https://openalex.org/C2777995511","wikidata":"https://www.wikidata.org/wiki/Q2897649","display_name":"TIMI","level":4,"score":0.8673907518386841},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7458134889602661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7175698280334473},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.7036431431770325},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6766618490219116},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.6003490090370178},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.5853250026702881},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5423008799552917},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4301249384880066},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.4235069453716278},{"id":"https://openalex.org/C2778271848","wikidata":"https://www.wikidata.org/wiki/Q386715","display_name":"Hirudin","level":4,"score":0.41781771183013916},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.08926314115524292}],"mesh":[{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005344","descriptor_name":"Fibrinopeptide A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024764","descriptor_name":"Hirudin Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0002-9149(96)00353-0","doi":"https://doi.org/10.1016/s0002-9149(96)00353-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","pdf_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","source":{"id":"https://openalex.org/S185186944","display_name":"The American Journal of Cardiology","issn_l":"0002-9149","issn":["0002-9149","1879-1913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Cardiology","raw_type":"journal-article"},{"id":"pmid:8806332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8806332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of cardiology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1016/s0002-9149(96)00353-0","doi":"https://doi.org/10.1016/s0002-9149(96)00353-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","pdf_url":"https://doi.org/10.1016/s0002-9149(96)00353-0","source":{"id":"https://openalex.org/S185186944","display_name":"The American Journal of Cardiology","issn_l":"0002-9149","issn":["0002-9149","1879-1913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963660637.pdf","grobid_xml":"https://content.openalex.org/works/W1963660637.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W21802224","https://openalex.org/W1512771871","https://openalex.org/W1971319904","https://openalex.org/W1992003098","https://openalex.org/W2008305192","https://openalex.org/W2032781826","https://openalex.org/W2036760282","https://openalex.org/W2047172923","https://openalex.org/W2065206445","https://openalex.org/W2071816794","https://openalex.org/W2077866784","https://openalex.org/W2124297695","https://openalex.org/W2170253441","https://openalex.org/W2187542142","https://openalex.org/W2266172904","https://openalex.org/W2339348678","https://openalex.org/W2409296984","https://openalex.org/W2410522723","https://openalex.org/W2421079549","https://openalex.org/W3025057188"],"related_works":["https://openalex.org/W2394807357","https://openalex.org/W2421079549","https://openalex.org/W2018104837","https://openalex.org/W1964523819","https://openalex.org/W1992003098","https://openalex.org/W1604564424","https://openalex.org/W2073096151","https://openalex.org/W2068050111","https://openalex.org/W2016990759","https://openalex.org/W2033431715"],"abstract_inverted_index":{"Thrombin":[0],"activity":[1,32,127,254],"is":[2],"increased":[3,176,184,197,213],"in":[4,30,38,51,71,131,134,137,231,258,262],"the":[5,20,39,52,76,93,135],"setting":[6],"of":[7,22,44,57,68,78,95,100,107,125,150,166,215,241,250],"acute":[8,26],"myocardial":[9],"infarction":[10],"(AMI)":[11],"and":[12,50,80,90,117,122,178,186,212,234,252],"has":[13],"been":[14],"shown":[15],"to":[16,41,46,54,73,91,161,227],"increase":[17,29],"further":[18],"after":[19,60],"administration":[21],"thrombolytic":[23,266],"therapy":[24,157,267],"for":[25,268],"infarction.":[27],"This":[28,142],"thrombin":[31,69],"may":[33,238,255],"play":[34],"an":[35],"important":[36],"role":[37,94],"15%":[40,55],"25%":[42],"rate":[43,56],"failure":[45],"achieve":[47],"initial":[48],"reperfusion":[49],"5%":[53],"early":[58],"reocclusion":[59],"initially":[61],"successful":[62],"thrombolysis.":[63],"To":[64],"investigate":[65,92],"potential":[66],"mechanisms":[67],"formation":[70],"vivo,":[72],"understand":[74],"better":[75],"balance":[77],"coagulation":[79],"fibrinolysis":[81],"during":[82],"treatment":[83],"with":[84,158,163,171,183,202,222,265],"recombinant":[85],"tissue-type":[86],"plasminogen":[87],"activator":[88],"(rt-PA),":[89],"hemostatic":[96],"markers":[97,106,167,219,249],"as":[98,154],"predictors":[99],"clinical":[101,172,260],"events,":[102],"we":[103],"measured":[104],"3":[105,217],"procoagulant":[108,218,251],"activity:":[109],"fibrinopeptide":[110],"A":[111],"(FPA),":[112],"thrombin-antithrombin":[113],"III":[114],"complexes":[115],"(TAT),":[116],"prothrombin":[118],"fragment":[119],"1.2":[120],"(F1.2),":[121],"a":[123,145],"marker":[124],"fibrinogenolytic":[126,253],"(B":[128],"beta":[129,236],"1-42)":[130],"patients":[132,162,263],"enrolled":[133],"Thrombolysis":[136],"Myocardial":[138],"Infarction":[139],"(TIMI)-5":[140],"study.":[141],"trial":[143,149],"was":[144],"randomized,":[146],"dose-ranging,":[147],"pilot":[148],"hirudin":[151],"versus":[152],"heparin":[153],"adjunctive":[155],"antithrombotic":[156],"rt-PA":[159],"administered":[160],"AMI.":[164,269],"Correlation":[165],"at":[168,194,209],"1":[169,207],"hour":[170],"outcomes":[173,261],"revealed":[174],"that":[175,247],"FPA":[177],"TAT":[179],"levels":[180,199,214],"were":[181,200,220],"associated":[182,201,221],"mortality":[185],"TIMI":[187,203],"grades":[188],"0,":[189],"1,":[190],"or":[191,206],"2":[192],"flow":[193,208],"90":[195,210],"minutes;":[196,211],"F1.2":[198],"grade":[204],"0":[205],"all":[216],"hemorrhagic":[223],"events.":[224],"Late":[225],"(12":[226],"24":[228],"hours)":[229],"increases":[230],"F1.2,":[232],"TAT,":[233],"B":[235],"1-42":[237],"be":[239,256],"predictive":[240],"recurrent":[242],"ischemia.":[243],"These":[244],"results":[245],"suggest":[246],"selected":[248],"useful":[257],"predicting":[259],"treated":[264]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
