{"id":"https://openalex.org/W1963644176","doi":"https://doi.org/10.1016/0378-1119(89)90019-x","title":"Human 6-phosphofructo-1-kinase gene has an additional intron upstream of start codon","display_name":"Human 6-phosphofructo-1-kinase gene has an additional intron upstream of start codon","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W1963644176","doi":"https://doi.org/10.1016/0378-1119(89)90019-x","mag":"1963644176","pmid":"https://pubmed.ncbi.nlm.nih.gov/2526044"},"language":"en","primary_location":{"id":"doi:10.1016/0378-1119(89)90019-x","doi":"https://doi.org/10.1016/0378-1119(89)90019-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-1119(89)90019-x","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089724364","display_name":"Benigno C. Valdez","orcid":"https://orcid.org/0000-0003-2471-8247","observed_orcids":["https://orcid.org/0000-0003-2471-8247"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benigno C. Valdez","raw_affiliation_strings":["Department of Biochemistry, Louisiana State University, Baton Rouge 70803","Stem Cell Transplantation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Louisiana State University, Baton Rouge 70803","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Stem Cell Transplantation","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chen Zhuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Zhuo","raw_affiliation_strings":["Department of Biochemistry, Louisiana State University, Baton Rouge, LA 70803 U.S.A. Tel. (504)388-8790","Louisiana State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Louisiana State University, Baton Rouge, LA 70803 U.S.A. Tel. (504)388-8790","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Louisiana State University**","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083606821","display_name":"Miguel G. Sosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I2801463575","display_name":"University Medical Center New Orleans","ror":"https://ror.org/02zrb2v54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel G. Sosa","raw_affiliation_strings":["Department of Medicine-Genetics, Louisiana State University Medical Center, New Orleans, LA 70112 U.S.A. Tel. (504)568-5867"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine-Genetics, Louisiana State University Medical Center, New Orleans, LA 70112 U.S.A. Tel. (504)568-5867","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I2801463575","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042317796","display_name":"Ezzat S. Younathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ezzat S. Younathan","raw_affiliation_strings":["Department of Biochemistry, Louisiana State University, Baton Rouge, LA 70803 U.S.A. Tel. (504)388-8790","Louisiana State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Louisiana State University, Baton Rouge, LA 70803 U.S.A. Tel. (504)388-8790","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Louisiana State University**","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103457477","display_name":"Simon H. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Simon H. Chang","raw_affiliation_strings":["Department of Biochemistry, Louisiana State University, Baton Rouge, LA 70803 U.S.A. Tel. (504)388-8790","Louisiana State University**"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Louisiana State University, Baton Rouge, LA 70803 U.S.A. Tel. (504)388-8790","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Louisiana State University**","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103457477"],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.9026,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.721893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"1","first_page":"167","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.10369999706745148,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.06710000336170197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-phosphofructokinase","display_name":"6-phosphofructokinase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/5-flanking-region","display_name":"5'-flanking region","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.6399999856948853},{"id":"https://openalex.org/keywords/at-rich-sequences","display_name":"AT-rich sequences","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cdna-sequence","display_name":"cDNA sequence","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8950965404510498},{"id":"https://openalex.org/C176990463","wikidata":"https://www.wikidata.org/wiki/Q1854186","display_name":"Start codon","level":4,"score":0.7656540870666504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7399873733520508},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.7202483415603638},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6387184262275696},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.6112534999847412},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5724238157272339},{"id":"https://openalex.org/C84148353","wikidata":"https://www.wikidata.org/wiki/Q863908","display_name":"Nucleic acid sequence","level":3,"score":0.5599603652954102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47505947947502136},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.25034892559051514}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010582","descriptor_name":"Bacteriophage lambda","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010732","descriptor_name":"Phosphofructokinase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0378-1119(89)90019-x","doi":"https://doi.org/10.1016/0378-1119(89)90019-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-1119(89)90019-x","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"pmid:2526044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2526044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1702772888","display_name":null,"funder_award_id":"DK31676","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1512701796","https://openalex.org/W1969600436","https://openalex.org/W1970587800","https://openalex.org/W1990831187","https://openalex.org/W2048507814","https://openalex.org/W2086483887","https://openalex.org/W2144634347","https://openalex.org/W2325826250","https://openalex.org/W2768517853","https://openalex.org/W4210965190"],"related_works":["https://openalex.org/W1989482213","https://openalex.org/W4282828664","https://openalex.org/W2093415114","https://openalex.org/W3144577499","https://openalex.org/W1987651013","https://openalex.org/W2433618683","https://openalex.org/W1985091138","https://openalex.org/W2018520589","https://openalex.org/W2022503185","https://openalex.org/W2067686397"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}