{"id":"https://openalex.org/W1963642121","doi":"https://doi.org/10.1634/stemcells.2005-0108","title":"Isolation and Characterization of Bipotent Liver Progenitor Cells from Adult Mouse","display_name":"Isolation and Characterization of Bipotent Liver Progenitor Cells from Adult Mouse","publication_year":2005,"publication_date":"2005-08-18","ids":{"openalex":"https://openalex.org/W1963642121","doi":"https://doi.org/10.1634/stemcells.2005-0108","mag":"1963642121","pmid":"https://pubmed.ncbi.nlm.nih.gov/16109753"},"language":"en","primary_location":{"id":"doi:10.1634/stemcells.2005-0108","doi":"https://doi.org/10.1634/stemcells.2005-0108","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2005-0108","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020133148","display_name":"Wenlin Li","orcid":"https://orcid.org/0000-0002-0842-222X","observed_orcids":["https://orcid.org/0000-0002-0842-222X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Lin Li","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675267","display_name":"Juan Su","orcid":"https://orcid.org/0009-0006-8827-6352","observed_orcids":["https://orcid.org/0009-0006-8827-6352"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Su","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003596325","display_name":"Yucheng Yao","orcid":"https://orcid.org/0000-0003-0483-9180","observed_orcids":["https://orcid.org/0000-0003-0483-9180"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Cheng Yao","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008068714","display_name":"Xinrong Tao","orcid":"https://orcid.org/0000-0002-2106-6039","observed_orcids":["https://orcid.org/0000-0002-2106-6039"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Rong Tao","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046322094","display_name":"Yong-Bi Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-Bi Yan","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong-Yu Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Yu Yu","raw_affiliation_strings":["Department of Pathology, Changzheng Hospital, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Changzheng Hospital, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006199471","display_name":"Xinmin Wang","orcid":"https://orcid.org/0009-0000-4516-8796","observed_orcids":["https://orcid.org/0009-0000-4516-8796","https://orcid.org/0000-0003-1675-327X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Min Wang","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101708134","display_name":"Jianxiu Li","orcid":"https://orcid.org/0000-0002-4631-8132","observed_orcids":["https://orcid.org/0000-0002-4631-8132"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Xiu Li","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100531401","display_name":"Yongji Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-Ji Yang","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074928934","display_name":"Joseph T.Y. Lau","orcid":"https://orcid.org/0000-0002-5128-2664","observed_orcids":["https://orcid.org/0000-0002-5128-2664"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph T.Y. Lau","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101960062","display_name":"Yiping Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Ping Hu","raw_affiliation_strings":["Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Second Military Medical University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101960062"],"corresponding_institution_ids":["https://openalex.org/I177933477"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":4.0715,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.93696749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"322","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-progenitor-cells","display_name":"liver progenitor cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mouse-liver","display_name":"mouse liver","score":0.503000020980835},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ductular-reaction","display_name":"ductular reaction","score":0.9480000138282776},{"id":"https://openalex.org/keywords/single-cell-cloning","display_name":"single-cell cloning","score":0.7020000219345093},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.746999979019165},{"id":"https://openalex.org/keywords/cd90","display_name":"CD90","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hepatocyte-differentiation","display_name":"hepatocyte differentiation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/biliary-differentiation","display_name":"biliary differentiation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/epithelial-growth-factor","display_name":"epithelial growth factor","score":0.828000009059906},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":1.0},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.6740000247955322},{"id":"https://openalex.org/keywords/liver-development","display_name":"liver development","score":0.8119999766349792},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8356208801269531},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.8091839551925659},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5544582009315491},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.5314192771911621},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.49073588848114014},{"id":"https://openalex.org/C195521686","wikidata":"https://www.wikidata.org/wiki/Q17152676","display_name":"Liver cytology","level":3,"score":0.4739789366722107},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4673956334590912},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4587353765964508},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45622003078460693},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4561772048473358},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.42721259593963623},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.41476064920425415},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4115177392959595},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36383187770843506},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2568631172180176},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.15797874331474304},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13897451758384705},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.09250542521476746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08955612778663635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08829289674758911},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0856611430644989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0673077404499054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011763","descriptor_name":"Pyrrolizidine Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1634/stemcells.2005-0108","doi":"https://doi.org/10.1634/stemcells.2005-0108","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2005-0108","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:16109753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16109753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W66677985","https://openalex.org/W120152232","https://openalex.org/W150568786","https://openalex.org/W1490154674","https://openalex.org/W1558031393","https://openalex.org/W1583618104","https://openalex.org/W1626384517","https://openalex.org/W1704142161","https://openalex.org/W1900842650","https://openalex.org/W1940331599","https://openalex.org/W1949977953","https://openalex.org/W1975655671","https://openalex.org/W1976183817","https://openalex.org/W1982022033","https://openalex.org/W1989245663","https://openalex.org/W1992201379","https://openalex.org/W1995026118","https://openalex.org/W1996884864","https://openalex.org/W1998479997","https://openalex.org/W1998666537","https://openalex.org/W2017200989","https://openalex.org/W2025571463","https://openalex.org/W2030648440","https://openalex.org/W2034179390","https://openalex.org/W2039396493","https://openalex.org/W2041782496","https://openalex.org/W2045762602","https://openalex.org/W2052534316","https://openalex.org/W2054556504","https://openalex.org/W2065737661","https://openalex.org/W2068460003","https://openalex.org/W2069676892","https://openalex.org/W2073613428","https://openalex.org/W2075363452","https://openalex.org/W2079733011","https://openalex.org/W2082239129","https://openalex.org/W2082686271","https://openalex.org/W2089154676","https://openalex.org/W2089282501","https://openalex.org/W2090800257","https://openalex.org/W2099755414","https://openalex.org/W2104428993","https://openalex.org/W2105649511","https://openalex.org/W2111367456","https://openalex.org/W2121054813","https://openalex.org/W2126070472","https://openalex.org/W2139364714","https://openalex.org/W2152429894","https://openalex.org/W2160818570","https://openalex.org/W2162179363","https://openalex.org/W2176186412","https://openalex.org/W2598336415","https://openalex.org/W4211173486","https://openalex.org/W4285719527","https://openalex.org/W4294235499","https://openalex.org/W6633321743","https://openalex.org/W6636601686"],"related_works":["https://openalex.org/W2083819316","https://openalex.org/W75725071","https://openalex.org/W2167943387","https://openalex.org/W2098346113","https://openalex.org/W1704142161","https://openalex.org/W2473256984","https://openalex.org/W1978851977","https://openalex.org/W2021158122","https://openalex.org/W2084807012","https://openalex.org/W1900842650"],"abstract_inverted_index":{"Liver":[0],"progenitor":[1,39,70,125],"cells":[2,40,139,171,200],"have":[3],"drawn":[4],"a":[5,96],"great":[6],"deal":[7],"of":[8,83,106,118,183,199,220,255],"attention":[9],"both":[10],"for":[11,16],"their":[12,17],"therapeutic":[13],"potential":[14,254],"and":[15,27,80,95,111,141,146,187,213,244,246],"usefulness":[18],"in":[19,59,152,234,241,250],"exploring":[20],"the":[21,30,84,100,104,107,112,116,119,181,218,221,252],"molecular":[22,239],"events":[23,240],"surrounding":[24],"liver":[25,34,57,69,124,211,242,256],"development":[26,243],"regeneration.":[28],"Despite":[29],"intensive":[31],"studies":[32],"on":[33],"progenitors":[35,58],"from":[36,42],"rats,":[37],"equivalent":[38],"derived":[41],"mice":[43],"are":[44],"relatively":[45],"rare.":[46],"We":[47],"used":[48],"retrosine":[49],"treatment":[50,159,173],"followed":[51],"by":[52,76,134],"partial":[53],"hepatectomy":[54],"to":[55,223,237],"elicit":[56],"mice.":[60],"From":[61],"these":[62,226],"animals":[63],"showing":[64],"prominent":[65],"ductular":[66],"reactions,":[67],"mouse-derived":[68,227],"cell":[71,126],"lines":[72],"(LEPCs)":[73],"were":[74,87],"isolated":[75],"single-cell":[77],"cloning.":[78],"Phenotypic":[79],"lineage":[81,170,194],"profiling":[82],"LEPC":[85],"clones":[86],"performed":[88],"using":[89],"immunochemistry,":[90],"reverse":[91],"transcription-polymerase":[92],"chain":[93],"reaction,":[94],"dual-color":[97],"system":[98],"comprising":[99],"reporter":[101,114],"EGFP":[102],"under":[103,115],"control":[105,117],"cytokeratin":[108],"19":[109],"promoter":[110],"DsRed":[113],"albumin":[120],"promoter.":[121],"LEPCs":[122,128,154,190,208,228],"expressed":[123,130],"markers.":[127],"also":[129],"some":[131],"markers":[132],"shared":[133],"bone":[135],"marrow-derived":[136],"hematopoietic":[137],"stem":[138,257],"c-Kit":[140],"Thy-1":[142],"but":[143],"not":[144],"CD34":[145],"CD45.":[147],"When":[148],"cultured":[149],"as":[150,233],"aggregates":[151],"Matrigel,":[153,189],"differentiated":[155,167,214],"into":[156,168,206,210,215],"hepatocyte":[157,177,202],"upon":[158,172],"with":[160,174,196],"50":[161],"ng/ml":[162,176],"epithelial":[163],"growth":[164,178],"factor":[165],"or":[166],"biliary":[169],"20":[175],"factor.":[179],"In":[180],"presence":[182],"2%":[184,188],"dimethyl":[185],"sulfoxide":[186],"acquired":[191],"predominantly":[192],"bile":[193],"phenotypes,":[195],"occasional":[197],"patches":[198],"exhibiting":[201],"phenotypes.":[203],"Upon":[204],"transplantation":[205],"CCl4-injured-liver,":[207],"engrafted":[209],"parenchyma":[212],"hepatocytes.":[216],"Considering":[217],"amenability":[219],"mouse":[222],"genetic":[224],"manipulation,":[225],"may":[229],"be":[230],"useful":[231],"tools":[232],"vitro":[235],"models":[236],"study":[238],"regeneration":[245],"can":[247],"shed":[248],"light":[249],"studying":[251],"therapy":[253],"cells.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}