{"id":"https://openalex.org/W1963628186","doi":"https://doi.org/10.1099/0022-1317-75-12-3393","title":"Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro","display_name":"Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro","publication_year":1994,"publication_date":"1994-12-01","ids":{"openalex":"https://openalex.org/W1963628186","doi":"https://doi.org/10.1099/0022-1317-75-12-3393","mag":"1963628186","pmid":"https://pubmed.ncbi.nlm.nih.gov/7527834"},"language":"en","primary_location":{"id":"doi:10.1099/0022-1317-75-12-3393","doi":"https://doi.org/10.1099/0022-1317-75-12-3393","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-75-12-3393","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069209710","display_name":"Luis J. Montaner","orcid":"https://orcid.org/0000-0001-5799-6759","observed_orcids":["https://orcid.org/0000-0001-5799-6759"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. J. Montaner","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, U.K","Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073088055","display_name":"Philip C. Griffin","orcid":"https://orcid.org/0000-0002-7112-4241","observed_orcids":["https://orcid.org/0000-0002-7112-4241"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Griffin","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060388462","display_name":"Siamon Gordon","orcid":"https://orcid.org/0000-0001-9967-3624","observed_orcids":["https://orcid.org/0000-0001-9967-3624"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Gordon","raw_affiliation_strings":["Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":2.442,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.88463837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"75","issue":"12","first_page":"3393","last_page":"3400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/reverse-transcription-inhibition","display_name":"reverse transcription inhibition","score":0.8149999976158142},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7210000157356262},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.7730000019073486},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.8230000138282776},{"id":"https://openalex.org/keywords/gag-gene","display_name":"gag gene","score":0.5770000219345093},{"id":"https://openalex.org/keywords/anti-hiv-1-activity","display_name":"anti-HIV-1 activity","score":0.4749999940395355},{"id":"https://openalex.org/keywords/cd4-cells","display_name":"CD4 cells","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8537073135375977},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.6178592443466187},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6022326946258545},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.594193696975708},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5784116387367249},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5178230404853821},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5026683807373047},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.4850408434867859},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4480465352535248},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43788617849349976},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43419724702835083},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.43329429626464844},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4121830463409424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29170113801956177},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1622757613658905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08328607678413391},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/0022-1317-75-12-3393","doi":"https://doi.org/10.1099/0022-1317-75-12-3393","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-75-12-3393","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:7527834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7527834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1503200131","https://openalex.org/W1510730676","https://openalex.org/W1723922714","https://openalex.org/W1853090825","https://openalex.org/W1856702249","https://openalex.org/W1934588590","https://openalex.org/W1938763205","https://openalex.org/W1961668980","https://openalex.org/W1969899610","https://openalex.org/W1970664121","https://openalex.org/W1971653058","https://openalex.org/W1974725456","https://openalex.org/W1975258429","https://openalex.org/W1975625627","https://openalex.org/W1990028169","https://openalex.org/W1991670386","https://openalex.org/W1992442658","https://openalex.org/W2036679171","https://openalex.org/W2075135942","https://openalex.org/W2084768146","https://openalex.org/W2099948570","https://openalex.org/W2104503802","https://openalex.org/W2115954882","https://openalex.org/W2145656711","https://openalex.org/W2154916884","https://openalex.org/W2170206314","https://openalex.org/W2191654227"],"related_works":["https://openalex.org/W2364175713","https://openalex.org/W119418178","https://openalex.org/W4283802959","https://openalex.org/W2019099201","https://openalex.org/W2368733723","https://openalex.org/W3138321581","https://openalex.org/W2083274803","https://openalex.org/W2058797471","https://openalex.org/W1779172654","https://openalex.org/W4250091031"],"abstract_inverted_index":{"Interleukin-10":[0],"(IL-10),":[1],"a":[2,57],"product":[3],"of":[4,90,131,141,155,186,230],"T":[5],"lymphocytes,":[6],"B":[7],"cells":[8,179],"and":[9,16,45,48,77,99,113,122,152,165,214],"macrophages,":[10],"participates":[11],"in":[12,51,56,199,219,226,233],"Th-2":[13],"immune":[14],"responses":[15],"modulates":[17],"macrophage":[18,212],"functions":[19],"including":[20],"possible":[21],"interactions":[22],"with":[23,189],"pathogens.":[24],"We":[25],"have":[26],"found":[27],"that":[28],"Chinese":[29],"hamster":[30],"ovary":[31],"cell-derived":[32],"human":[33,38],"recombinant":[34],"(hr)":[35],"IL-10":[36,62,127,172,194,206,222],"inhibits":[37],"immunodeficiency":[39],"virus":[40,187],"type":[41],"1":[42],"strains":[43],"Ada":[44],"Ba-L":[46],"(HIV-1ADA":[47],"HIV-1Ba-L)":[49],"replication":[50],"primary":[52],"tissue":[53],"culture-derived":[54],"macrophages":[55,232],"dose-dependent":[58],"manner.":[59],"Inhibition":[60],"by":[61,81,96,124,147,160,166],"treatment":[63],"(>":[64],"5":[65],"U/ml)":[66],"was":[67,94,145,158,197],"effective":[68,228],"72":[69],"h":[70,74,151,164,169],"before":[71,181],"or":[72,85],"24":[73,163],"after":[75,87,120,170,176,192],"infection":[76,121,132,182,213],"cytokine":[78,177],"activity":[79,196],"blocked":[80],"anti-hrIL-10":[82],"antibody":[83],"(19F1),":[84],"lost":[86],"heat":[88],"inactivation":[89],"IL-10.":[91],"Viral":[92],"production":[93],"measured":[95],"determining":[97],"p24":[98],"reverse":[100,104,143,209],"transcriptase":[101],"levels":[102,185],"while":[103],"transcription":[105,144,210],"kinetics":[106],"for":[107],"the":[108,153,227],"long":[109],"terminal":[110],"repeat":[111],"(LTR)":[112],"gag":[114],"were":[115,174],"assessed":[116],"at":[117,162],"timed":[118],"intervals":[119],"quantified":[123],"32P":[125],"end-labelling.":[126],"inhibited":[128],"early":[129],"steps":[130],"without":[133],"modulating":[134],"cell":[135],"surface":[136],"CD4+":[137],"levels.":[138],"The":[139],"onset":[140],"LTR":[142,156],"delayed":[146],"4":[148],"to":[149],"8":[150],"number":[154],"transcripts":[157],"decreased":[159],"77%":[161],"87%":[167],"48":[168],"infection.":[171,193],"effects":[173],"reversible;":[175],"washout,":[178],"treated":[180,191],"showed":[183],"lower":[184],"compared":[188],"those":[190],"biological":[195],"confirmed":[198],"three":[200],"virus-independent":[201],"assays.":[202],"These":[203],"results":[204],"demonstrate":[205],"decreases":[207],"HIV-1":[208],"upon":[211],"subsequently":[215],"mediates":[216],"viral":[217],"latency":[218],"vitro.":[220],"Therefore,":[221],"may":[223],"be":[224],"involved":[225],"control":[229],"HIV-1-infected":[231],"vivo.":[234]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}
