{"id":"https://openalex.org/W1963619306","doi":"https://doi.org/10.1152/ajpregu.00214.2003","title":"Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats","display_name":"Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats","publication_year":2004,"publication_date":"2004-01-30","ids":{"openalex":"https://openalex.org/W1963619306","doi":"https://doi.org/10.1152/ajpregu.00214.2003","mag":"1963619306","pmid":"https://pubmed.ncbi.nlm.nih.gov/14563657"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00214.2003","doi":"https://doi.org/10.1152/ajpregu.00214.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00214.2003","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047968747","display_name":"Ken\u2010ichiro Hayashida","orcid":"https://orcid.org/0000-0001-6397-5444","observed_orcids":["https://orcid.org/0000-0001-6397-5444"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichiro Hayashida","raw_affiliation_strings":["Dept. of Veterinary Physiology, Faculty of Agriculture, Tottori Univ., Tottori 680-0945, Japan","Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori 680-0945, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Veterinary Physiology, Faculty of Agriculture, Tottori Univ., Tottori 680-0945, Japan","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori 680-0945, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001134032","display_name":"Takashi Takeuchi","orcid":"https://orcid.org/0000-0001-9308-1302","observed_orcids":["https://orcid.org/0000-0001-9308-1302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Takeuchi","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112319337","display_name":"Takeshi Ozaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Ozaki","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hirohiko Shimizu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirohiko Shimizu","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113699056","display_name":"Kunio Ando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunio Ando","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045926885","display_name":"Atsushi Miyamoto","orcid":"https://orcid.org/0000-0002-1980-2869","observed_orcids":["https://orcid.org/0000-0002-1980-2869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsushi Miyamoto","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113552156","display_name":"Etsumori Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Etsumori Harada","raw_affiliation_strings":["","tottori university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"tottori university","institution_ids":["https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2008,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.74972828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"286","issue":"2","first_page":"R359","last_page":"R365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-lactoferrin","display_name":"bovine lactoferrin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.9309999942779541},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6150000095367432},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.8759999871253967},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.8389999866485596},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.7229999899864197},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9020000100135803},{"id":"https://openalex.org/keywords/aortic-relaxation","display_name":"aortic relaxation","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.635257363319397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6055585145950317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.594233512878418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.524181067943573},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.4963832497596741},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4958828389644623},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.4857816994190216},{"id":"https://openalex.org/C153461711","wikidata":"https://www.wikidata.org/wiki/Q5072487","display_name":"Channel blocker","level":3,"score":0.4727509915828705},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.43057170510292053},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.42988860607147217},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.410998672246933},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3540502190589905},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3264603614807129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29926198720932007},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27791985869407654},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.16619762778282166},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.07957983016967773}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.00214.2003","doi":"https://doi.org/10.1152/ajpregu.00214.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00214.2003","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:14563657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14563657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W49088916","https://openalex.org/W167961668","https://openalex.org/W941173698","https://openalex.org/W1965895043","https://openalex.org/W1985428994","https://openalex.org/W1988979797","https://openalex.org/W1991978604","https://openalex.org/W1995771491","https://openalex.org/W1995932730","https://openalex.org/W1996238386","https://openalex.org/W1997540603","https://openalex.org/W1998004568","https://openalex.org/W2000233490","https://openalex.org/W2003807878","https://openalex.org/W2006305777","https://openalex.org/W2019783997","https://openalex.org/W2022597247","https://openalex.org/W2027970428","https://openalex.org/W2034823787","https://openalex.org/W2035678291","https://openalex.org/W2045739557","https://openalex.org/W2046523416","https://openalex.org/W2047205198","https://openalex.org/W2060377895","https://openalex.org/W2066808891","https://openalex.org/W2073453216","https://openalex.org/W2074178023","https://openalex.org/W2074421138","https://openalex.org/W2077742197","https://openalex.org/W2083907754","https://openalex.org/W2085118021","https://openalex.org/W2090968114","https://openalex.org/W2100477885","https://openalex.org/W2116286111","https://openalex.org/W2117208403","https://openalex.org/W2123339576","https://openalex.org/W2134739752","https://openalex.org/W2135527870","https://openalex.org/W2152909969","https://openalex.org/W2155414406","https://openalex.org/W2158710625","https://openalex.org/W2160720951","https://openalex.org/W2170166188","https://openalex.org/W2277749601","https://openalex.org/W2286683639","https://openalex.org/W2335211542","https://openalex.org/W2417733688"],"related_works":["https://openalex.org/W4297965283","https://openalex.org/W2035988892","https://openalex.org/W4386403688","https://openalex.org/W2743782065","https://openalex.org/W2320456832","https://openalex.org/W2024364379","https://openalex.org/W2001862039","https://openalex.org/W1980834994","https://openalex.org/W1776360753","https://openalex.org/W2084289214"],"abstract_inverted_index":{"Lactoferrin":[0],"(LF)":[1],"is":[2,7,21,34,218],"a":[3],"multifunctional":[4],"protein":[5],"that":[6,209,217,225],"found":[8],"in":[9,23,59,68,80,175],"milk,":[10],"neutrophils,":[11],"and":[12,55,62,95,224],"other":[13],"biological":[14],"fluids.":[15],"Under":[16],"inflammatory":[17],"conditions,":[18],"LF":[19,33,47],"production":[20,223],"increased":[22],"the":[24,29,38,43,50,63,69,88,112,126,135,146,161,168,200,233],"periphery":[25],"by":[26,105,119,134,145,160,188,193,197,221,232],"neutrophils.":[27],"However,":[28],"cardiovascular":[30],"function":[31,65],"of":[32,45,66,75,100,149],"still":[35],"unknown.":[36],"In":[37],"present":[39],"study,":[40],"we":[41],"investigated":[42],"effect":[44,99],"bovine":[46],"(BLF)":[48],"on":[49],"mean":[51],"blood":[52],"pressure":[53],"(MBP)":[54],"heart":[56],"rate":[57],"(HR)":[58],"urethane-anesthetized":[60],"rats":[61],"vascular":[64],"BLF":[67,76,101,172,189,210],"rat":[70],"thoracic":[71],"aorta.":[72],"Intravenous":[73],"injection":[74],"produced":[77,173],"dose-dependent":[78],"decreases":[79],"MBP":[81,94],"but":[82,115,143,177,195],"did":[83],"not":[84,103,144,158,178,196],"affect":[85],"HR,":[86],"while":[87],"opioid":[89],"agonist":[90],"morphine":[91],"decreased":[92],"both":[93],"HR.":[96],"The":[97,185],"hypotensive":[98],"was":[102,116,131,157,190],"altered":[104,159],"naloxone":[106,120],"methiodide,":[107],"which":[108,122],"cannot":[109],"pass":[110,124],"through":[111,125],"blood-brain":[113,127],"barrier,":[114],"significantly":[117],"reduced":[118],"hydrochloride,":[121],"does":[123],"barrier.":[128],"BLF-induced":[129,155,226],"hypotension":[130,156,212,227],"completely":[132,191],"blocked":[133,192],"NO":[136,222],"synthase":[137],"inhibitor":[138,170],"NG-nitro-l-arginine":[139],"methyl":[140,152],"ester":[141,153],"(l-NAME)":[142],"inactive":[147],"enantiomer":[148],"l-NAME,":[150],"NG-nitro-d-arginine":[151],"(d-NAME).":[154],"muscarinic":[162],"ACh":[163],"receptor":[164],"antagonist":[165],"atropine":[166],"or":[167,199],"cyclooxygenase":[169],"diclofenac.":[171],"relaxation":[174,186],"endothelium-intact":[176],"endothelium-denuded":[179],"aortic":[180],"rings":[181],"precontracted":[182],"with":[183],"phenylephrine.":[184],"evoked":[187],"l-NAME":[194],"d-NAME":[198],"ATP-sensitive":[201],"potassium":[202],"channel":[203],"blocker":[204],"glibenclamide.":[205],"These":[206],"results":[207],"suggest":[208],"causes":[211],"via":[213],"an":[214],"endothelium-dependent":[215],"vasodilation":[216],"strongly":[219],"mediated":[220,231],"also":[228],"may":[229],"be":[230],"central":[234],"opioidergic":[235],"system.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
