{"id":"https://openalex.org/W1963604265","doi":"https://doi.org/10.2337/diab.40.12.1630","title":"Intestinal and Hepatic Cholesterogenesis in Hypercholesterolemic Dyslipidemia of Experimental Diabetes in Dogs","display_name":"Intestinal and Hepatic Cholesterogenesis in Hypercholesterolemic Dyslipidemia of Experimental Diabetes in Dogs","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W1963604265","doi":"https://doi.org/10.2337/diab.40.12.1630","mag":"1963604265","pmid":"https://pubmed.ncbi.nlm.nih.gov/1756903"},"language":"en","primary_location":{"id":"doi:10.2337/diab.40.12.1630","doi":"https://doi.org/10.2337/diab.40.12.1630","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.40.12.1630","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111682637","display_name":"Linda K. Kwong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda K Kwong","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080994","display_name":"Kenneth R. Feingold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth R Feingold","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002853073","display_name":"Ludvic Peric-Golia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ludvic Peric-Golia","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009200939","display_name":"Thanh Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh Le","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109974105","display_name":"John D. Karkas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D Karkas","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108454557","display_name":"Alfred W. Alberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred W Alberts","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111613983","display_name":"Dana E. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana E Wilson","raw_affiliation_strings":["Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center\u2008Salt Lake City; and the Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Utah School of Medicine\u2008Salt Lake City; Utah; the Department of Medicine, University of California\u2008San Francisco; and the Veterans Affairs Medical Center, Metabolism Section (111F)\u2008San Francisco, California; and the Merck Sharp and Dohme Research Laboratories\u2008Rahway, New Jersey","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5245,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.88439912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"40","issue":"12","first_page":"1630","last_page":"1639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7730000019073486},{"id":"https://openalex.org/keywords/intestinal-cholesterol-synthesis","display_name":"intestinal cholesterol synthesis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hepatic-cholesterol-synthesis","display_name":"hepatic cholesterol synthesis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hdl1","display_name":"HDL1","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hdl-subfractions","display_name":"HDL subfractions","score":0.6919999718666077},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6899999976158142},{"id":"https://openalex.org/keywords/intestinal-hypertrophy","display_name":"intestinal hypertrophy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/mevalonate","display_name":"mevalonate","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hyperphagia","display_name":"hyperphagia","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8728936910629272},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8249359130859375},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.655960202217102},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5070555210113525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4592250883579254},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.4207339286804199},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.4127786457538605}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.40.12.1630","doi":"https://doi.org/10.2337/diab.40.12.1630","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.40.12.1630","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.40.12.1630","doi":"https://doi.org/10.2337/diabetes.40.12.1630","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.40.12.1630","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:1756903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1756903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320317828","display_name":"Nora Eccles Treadwell Foundation","ror":"https://ror.org/028zcv790"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051666284","https://openalex.org/W2157447812","https://openalex.org/W2166635929","https://openalex.org/W2331575954","https://openalex.org/W1965330823","https://openalex.org/W2167458763","https://openalex.org/W2065472731","https://openalex.org/W2027447562","https://openalex.org/W2187093360","https://openalex.org/W2054435379"],"abstract_inverted_index":{"We":[0],"previously":[1],"reported":[2],"that":[3,164,172,189],"dog":[4,183],"diabetes":[5,184],"results":[6],"in":[7,54,91,150,154,159,165,177,182,196],"hypercholesterolemia":[8,181,198],"and":[9,26,31,62,76,93,123,129,134,152,185],"the":[10,55,178,187,197],"accumulation":[11],"of":[12,115,139,180,199],"a":[13,194],"high-density":[14],"lipoprotein":[15],"(HDL)":[16],"subclass,":[17],"HDL1.":[18],"Hypercholesterolemic":[19],"diabetic":[20,57,66],"rodents":[21],"exhibit":[22],"hyperphagia,":[23],"intestinal":[24,28,33,63,173],"hypertrophy,":[25],"increased":[27,120,148,190],"cholesterol":[29,117,191],"synthesis":[30,192],"absorption;":[32],"3-hydroxy-3-methylglutaryl":[34],"(HMG)":[35],"CoA":[36,141],"reductase":[37,142],"activity":[38,43,138,158],"is":[39,44,175],"increased,":[40,128],"whereas":[41],"hepatic":[42,61,94,124],"unchanged":[45],"or":[46],"reduced.":[47],"To":[48],"determine":[49],"whether":[50],"similar":[51],"mechanisms":[52],"operate":[53],"hypercholesterolemic":[56,77],"dog,":[58],"we":[59],"measured":[60],"cholesterologenesis.":[64],"Streptozocin-alloxan-induced":[65],"dogs":[67],"allowed":[68],"access":[69],"to":[70],"food":[71],"ad":[72],"libitum":[73],"were":[74,87,96,126],"hyperphagic":[75],"(10.1":[78],"vs.":[79],"4.47":[80],"mM)":[81],"but":[82],"normotriglyceridemic.":[83],"Plasma":[84],"HDL1":[85],"concentrations":[86],"markedly":[88],"increased.":[89],"Differences":[90],"renal":[92],"function":[95],"not":[97],"statistically":[98],"significant,":[99],"except":[100],"serum":[101],"alkaline":[102],"phosphatase,":[103],"which":[104],"was":[105,119,147,161],"elevated":[106],"4-fold":[107],"(P":[108],"=":[109],"0.0003).":[110],"Urinary":[111],"mevalonate,":[112],"an":[113],"index":[114],"whole-body":[116],"synthesis,":[118],"6-fold.":[121],"Intestinal":[122],"weights":[125],"both":[127],"direct":[130],"measurements":[131],"showed":[132],"crypt":[133],"villus":[135],"thickening.":[136],"The":[137],"HMG":[140],"per":[143],"gram":[144],"organ":[145],"weight":[146],"1.7-fold":[149],"liver":[151],"2.1-fold":[153],"intestine.":[155],"Calculated":[156],"whole-organ":[157],"intestine":[160],"nearly":[162],"twice":[163],"liver.":[166],"These":[167],"observations":[168],"provide":[169],"strong":[170],"evidence":[171],"cholesterogenesis":[174],"involved":[176],"pathogenesis":[179],"support":[186],"conclusion":[188],"plays":[193],"role":[195],"diabetes.":[200]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}