{"id":"https://openalex.org/W1963603371","doi":"https://doi.org/10.1007/s00109-008-0368-5","title":"A central role for free heme in the pathogenesis of severe malaria: the missing link?","display_name":"A central role for free heme in the pathogenesis of severe malaria: the missing link?","publication_year":2008,"publication_date":"2008-07-18","ids":{"openalex":"https://openalex.org/W1963603371","doi":"https://doi.org/10.1007/s00109-008-0368-5","mag":"1963603371","pmid":"https://pubmed.ncbi.nlm.nih.gov/18641963"},"language":"en","primary_location":{"id":"doi:10.1007/s00109-008-0368-5","doi":"https://doi.org/10.1007/s00109-008-0368-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00109-008-0368-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-008-0368-5.pdf","source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00109-008-0368-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037563280","display_name":"Ana Catharyna Estrela Ferreira","orcid":"https://orcid.org/0000-0002-9171-6068","observed_orcids":["https://orcid.org/0000-0002-9171-6068"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Ferreira","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051937204","display_name":"J\u00f3zsef Balla","orcid":"https://orcid.org/0000-0001-7923-2645","observed_orcids":["https://orcid.org/0000-0001-7923-2645"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J\u00f3zsef Balla","raw_affiliation_strings":["Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, 4032, Debrecen, Hungary","Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, 4032, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075376414","display_name":"Vikt\u00f3ria Jeney","orcid":"https://orcid.org/0000-0003-4942-7091","observed_orcids":["https://orcid.org/0000-0003-4942-7091"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Vikt\u00f3ria Jeney","raw_affiliation_strings":["Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, 4032, Debrecen, Hungary","Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, 4032, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109306699","display_name":"Gy\u00f6rgy Balla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gy\u00f6rgy Balla","raw_affiliation_strings":["Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, 4032, Debrecen, Hungary","Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, 4032, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]},{"raw_affiliation_string":"Departments of Medicine and Neonatology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067643807","display_name":"Miguel Parreira Soares","orcid":"https://orcid.org/0000-0002-9314-4833","observed_orcids":["https://orcid.org/0000-0002-9314-4833"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Miguel P. Soares","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, 2780\u2013156, Oeiras, Portugal","Instituto Gulbenkian de Ci\u00eancia; Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, 2780\u2013156, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia; Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067643807"],"corresponding_institution_ids":["https://openalex.org/I48057805"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.4467,"has_fulltext":true,"cited_by_count":209,"citation_normalized_percentile":{"value":0.78950777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"86","issue":"10","first_page":"1097","last_page":"1111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.27000001072883606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cerebral-malaria","display_name":"cerebral malaria","score":0.9559999704360962},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9419999718666077},{"id":"https://openalex.org/keywords/free-heme","display_name":"free heme","score":0.9559999704360962},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.871999979019165},{"id":"https://openalex.org/keywords/free-hemoglobin","display_name":"free hemoglobin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/biliverdin","display_name":"biliverdin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.4819999933242798},{"id":"https://openalex.org/keywords/rodent-malaria-model","display_name":"rodent malaria model","score":0.777999997138977},{"id":"https://openalex.org/keywords/malaria-pathogenesis","display_name":"malaria pathogenesis","score":0.5789999961853027},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2908793570","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Cerebral Malaria","level":4,"score":0.8709436655044556},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.788115382194519},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.784095048904419},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7828209400177002},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.5983543395996094},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.5418184399604797},{"id":"https://openalex.org/C2776253728","wikidata":"https://www.wikidata.org/wiki/Q422964","display_name":"Biliverdin","level":5,"score":0.5341094732284546},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.5338505506515503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5311509370803833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49436092376708984},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4884413778781891},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4542560577392578},{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.4245394468307495},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.199529230594635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1185545027256012},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09508982300758362},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016779","descriptor_name":"Malaria, Cerebral","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016779","descriptor_name":"Malaria, Cerebral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016779","descriptor_name":"Malaria, Cerebral","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00109-008-0368-5","doi":"https://doi.org/10.1007/s00109-008-0368-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00109-008-0368-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-008-0368-5.pdf","source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:18641963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18641963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular medicine (Berlin, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:12930","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/12930/1/1239492.pdf","pdf_url":"http://real.mtak.hu/12930/1/1239492.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dea.lib.unideb.hu:2437/82380","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1007/s00109-008-0368-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"foly\u00f3iratcikk"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/82380","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/82380","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"}],"best_oa_location":{"id":"doi:10.1007/s00109-008-0368-5","doi":"https://doi.org/10.1007/s00109-008-0368-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00109-008-0368-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-008-0368-5.pdf","source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G169337059","display_name":null,"funder_award_id":"RET-06/2004","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G6738607125","display_name":null,"funder_award_id":"11003","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G738917718","display_name":"Heme oxigenase-1: regulador do efeito protector da Anemia Falciforme contra o desenvolvimento de Mal\u00e1ria Cerebral","funder_award_id":"PTDC/SAU-MII/71140/2006","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320325035","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963603371.pdf","grobid_xml":"https://content.openalex.org/works/W1963603371.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W176468989","https://openalex.org/W1500284214","https://openalex.org/W1500754345","https://openalex.org/W1509804778","https://openalex.org/W1517026994","https://openalex.org/W1535567348","https://openalex.org/W1594909253","https://openalex.org/W1600690434","https://openalex.org/W1602122856","https://openalex.org/W1621595817","https://openalex.org/W1870494617","https://openalex.org/W1903666634","https://openalex.org/W1965109486","https://openalex.org/W1966582616","https://openalex.org/W1967434989","https://openalex.org/W1972048560","https://openalex.org/W1973664534","https://openalex.org/W1982293312","https://openalex.org/W1982977768","https://openalex.org/W1983531823","https://openalex.org/W1986525923","https://openalex.org/W1992494631","https://openalex.org/W1993198132","https://openalex.org/W1994364461","https://openalex.org/W1998055077","https://openalex.org/W2001382332","https://openalex.org/W2003590875","https://openalex.org/W2005234042","https://openalex.org/W2021650047","https://openalex.org/W2022203801","https://openalex.org/W2023459898","https://openalex.org/W2025765364","https://openalex.org/W2025928231","https://openalex.org/W2028778467","https://openalex.org/W2030707725","https://openalex.org/W2030928461","https://openalex.org/W2034184306","https://openalex.org/W2037159578","https://openalex.org/W2039227742","https://openalex.org/W2039941241","https://openalex.org/W2040755930","https://openalex.org/W2044879397","https://openalex.org/W2048992607","https://openalex.org/W2051478582","https://openalex.org/W2055629622","https://openalex.org/W2057467676","https://openalex.org/W2058844821","https://openalex.org/W2060000199","https://openalex.org/W2063838707","https://openalex.org/W2065284764","https://openalex.org/W2068006559","https://openalex.org/W2072222144","https://openalex.org/W2079697817","https://openalex.org/W2079744876","https://openalex.org/W2085077927","https://openalex.org/W2086567353","https://openalex.org/W2087450601","https://openalex.org/W2087583468","https://openalex.org/W2094477505","https://openalex.org/W2094951825","https://openalex.org/W2095371540","https://openalex.org/W2107734982","https://openalex.org/W2108555819","https://openalex.org/W2111646717","https://openalex.org/W2111897470","https://openalex.org/W2118493661","https://openalex.org/W2119428502","https://openalex.org/W2120505405","https://openalex.org/W2120724865","https://openalex.org/W2124568143","https://openalex.org/W2128378359","https://openalex.org/W2129535784","https://openalex.org/W2131407151","https://openalex.org/W2141570707","https://openalex.org/W2144188747","https://openalex.org/W2145541325","https://openalex.org/W2147504939","https://openalex.org/W2149821716","https://openalex.org/W2150027863","https://openalex.org/W2153461158","https://openalex.org/W2158813976","https://openalex.org/W2160738020","https://openalex.org/W2162093925","https://openalex.org/W2164631866","https://openalex.org/W2166803343","https://openalex.org/W2169450299","https://openalex.org/W2169952241","https://openalex.org/W2171898271","https://openalex.org/W2171931467","https://openalex.org/W2172258104","https://openalex.org/W2176516792","https://openalex.org/W2322213143","https://openalex.org/W2372726278","https://openalex.org/W2411463711","https://openalex.org/W2460998429","https://openalex.org/W2566053029","https://openalex.org/W2979171911","https://openalex.org/W3143442086","https://openalex.org/W4241694836","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2158040122","https://openalex.org/W2021650047","https://openalex.org/W2566526248","https://openalex.org/W176468989","https://openalex.org/W1982370340","https://openalex.org/W3215454187","https://openalex.org/W7131801016","https://openalex.org/W4391487288","https://openalex.org/W2094951825","https://openalex.org/W1870494617"],"abstract_inverted_index":{"Malaria,":[0],"the":[1,17,27,40,88,93,101,123,137,163,193,207,214,220],"disease":[2],"caused":[3],"by":[4,100,134],"Plasmodium":[5,15,20,56,167,224],"infection,":[6,57,75],"is":[7,84,105,147],"endemic":[8],"to":[9,54,91,152,172,187,233],"poverty":[10],"in":[11,22,59,192],"so-called":[12],"underdeveloped":[13],"countries.":[14],"falciparum,":[16],"main":[18],"infectious":[19],"species":[21],"sub-Saharan":[23],"countries,":[24],"can":[25],"trigger":[26],"development":[28],"of":[29,42,73,80,95,129,139,145,166,170,181,195,210,216,223],"severe":[30],"malaria,":[31,34],"including":[32,213],"cerebral":[33,140,196],"a":[35,81,106,116,189],"neurological":[36],"syndrome":[37],"that":[38,78,109,118,205],"claims":[39],"lives":[41],"more":[43],"than":[44],"one":[45],"million":[46],"children":[47],"(<5":[48],"years":[49],"old)":[50],"per":[51],"year.":[52],"Attempts":[53],"eradicate":[55],"and":[58,121,178,226],"particular":[60],"its":[61,150,235],"lethal":[62,236],"outcomes,":[63],"have":[64],"so":[65],"far":[66],"been":[67],"unsuccessful.":[68],"Using":[69],"well-established":[70],"rodent":[71],"models":[72],"malaria":[74],"we":[76,185],"found":[77,186],"survival":[79],"Plasmodium-infected":[82],"host":[83],"strictly":[85],"dependent":[86],"on":[87,219],"host's":[89],"ability":[90],"up-regulate":[92],"expression":[94,215],"heme":[96,112,132,176],"oxygenase-1":[97],"(HO-1":[98],"encoded":[99],"gene":[102],"Hmox1).":[103],"HO-1":[104,135],"stress-responsive":[107],"enzyme":[108],"catabolizes":[110],"free":[111,182,211],"into":[113],"biliverdin,":[114],"via":[115,149],"reaction":[117],"releases":[119],"Fe":[120],"generates":[122],"gas":[124],"carbon":[125],"monoxide":[126],"(CO).":[127],"Generation":[128],"CO":[130,146,171],"through":[131],"catabolism":[133],"prevents":[136,175],"onset":[138],"malaria.":[141,197],"The":[142],"protective":[143],"effect":[144],"mediated":[148],"binding":[151],"cell-free":[153,173],"hemoglobin":[154],"(Hb)":[155],"released":[156],"from":[157],"infected":[158],"red":[159],"blood":[160,164],"cells":[161],"during":[162],"stage":[165],"infection.":[168],"Binding":[169],"Hb":[174],"release":[177],"thus":[179],"generation":[180],"heme,":[183,212],"which":[184],"play":[188],"central":[190],"role":[191],"pathogenesis":[194],"We":[198],"will":[199],"address":[200],"hereby":[201],"how":[202,227],"defense":[203],"mechanisms":[204],"prevent":[206],"deleterious":[208],"effects":[209],"HO-1,":[217],"impact":[218],"pathologic":[221],"outcome":[222],"infection":[225],"these":[228],"may":[229],"be":[230],"used":[231],"therapeutically":[232],"suppress":[234],"outcomes.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}