{"id":"https://openalex.org/W1963595907","doi":"https://doi.org/10.1136/bmj.4.5577.446","title":"Current concepts in the treatment of anovulation.","display_name":"Current concepts in the treatment of anovulation.","publication_year":1967,"publication_date":"1967-11-25","ids":{"openalex":"https://openalex.org/W1963595907","doi":"https://doi.org/10.1136/bmj.4.5577.446","mag":"1963595907","pmid":"https://pubmed.ncbi.nlm.nih.gov/6069754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1748542"},"language":"en","primary_location":{"id":"doi:10.1136/bmj.4.5577.446","doi":"https://doi.org/10.1136/bmj.4.5577.446","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmj.4.5577.446","pdf_url":"https://www.bmj.com/content/bmj/4/5577/446.full.pdf","source":{"id":"https://openalex.org/S4393911389","display_name":"BMJ","issn_l":"0007-1447","issn":["0007-1447","0267-0623","1468-5833"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.bmj.com/content/bmj/4/5577/446.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023674114","display_name":"Erwin Rabau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E Rabau","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109854278","display_name":"David M. Serr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"D M Serr","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111956854","display_name":"Shlomo Mashiach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"S Mashiach","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113482410","display_name":"Vaclav Insler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"V Insler","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013572930","display_name":"M Salomy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Salomy","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Tel-Hashomer Govern-ment Hospital and Tel Aviv University Medical School, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034812353","display_name":"Bruno Lunenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"B Lunenfeld","raw_affiliation_strings":["Institute of Endocrinology, Tel-Hashomer Government Hospital and","Tel Aviv University Medical School, Tel Aviv, Israel","Brit. med. ","Departments of Medicine in Karlstad, Malmb, and Angelholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Endocrinology, Tel-Hashomer Government Hospital and","institution_ids":[]},{"raw_affiliation_string":"Tel Aviv University Medical School, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Brit. med. ","institution_ids":[]},{"raw_affiliation_string":"Departments of Medicine in Karlstad, Malmb, and Angelholm, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":null,"apc_paid":null,"fwci":2.3168,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.84936387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"4","issue":"5577","first_page":"446","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anovulation","display_name":"anovulation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/clomiphene","display_name":"clomiphene citrate","score":0.9160000085830688},{"id":"https://openalex.org/keywords/polycystic-ovary","display_name":"polycystic ovary","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.828000009059906},{"id":"https://openalex.org/keywords/conception-rate","display_name":"conception rate","score":0.8399999737739563},{"id":"https://openalex.org/keywords/menstrual-cycle-length","display_name":"menstrual cycle length","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.722000002861023},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2780853582","wikidata":"https://www.wikidata.org/wiki/Q25556","display_name":"Anovulation","level":5,"score":0.8339564800262451},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.5337501764297485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34765952825546265},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.15110287070274353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13804081082344055},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.1048574149608612},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002640","descriptor_name":"Chiari-Frommel Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002996","descriptor_name":"Clomiphene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006065","descriptor_name":"Gonadotropins, Pituitary","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/bmj.4.5577.446","doi":"https://doi.org/10.1136/bmj.4.5577.446","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmj.4.5577.446","pdf_url":"https://www.bmj.com/content/bmj/4/5577/446.full.pdf","source":{"id":"https://openalex.org/S4393911389","display_name":"BMJ","issn_l":"0007-1447","issn":["0007-1447","0267-0623","1468-5833"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1748542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1748542","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br Med J","raw_type":"Text"},{"id":"pmid:6069754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6069754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:bmj:4/5577/446","doi":null,"is_oa":false,"landing_page_url":"http://www.bmj.com/cgi/content/short/4/5577/446","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/bmj.4.5577.446","doi":"https://doi.org/10.1136/bmj.4.5577.446","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmj.4.5577.446","pdf_url":"https://www.bmj.com/content/bmj/4/5577/446.full.pdf","source":{"id":"https://openalex.org/S4393911389","display_name":"BMJ","issn_l":"0007-1447","issn":["0007-1447","0267-0623","1468-5833"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963595907.pdf","grobid_xml":"https://content.openalex.org/works/W1963595907.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1540043912","https://openalex.org/W1764010703","https://openalex.org/W1900456834","https://openalex.org/W1937605694","https://openalex.org/W2004229691","https://openalex.org/W2069404684","https://openalex.org/W2277175521","https://openalex.org/W2409399490","https://openalex.org/W2411421526","https://openalex.org/W2983860270","https://openalex.org/W4302417105"],"related_works":["https://openalex.org/W2417424175","https://openalex.org/W2025506044","https://openalex.org/W2167937580","https://openalex.org/W2555240246","https://openalex.org/W2576479526","https://openalex.org/W7097427281","https://openalex.org/W166435599","https://openalex.org/W2028343900","https://openalex.org/W2277647539","https://openalex.org/W2206848166"],"abstract_inverted_index":{"MEDIBCAILIJUNAL":[0],"residual":[1],"follicle":[2,17],"stimulating":[3,18],"hormone":[4,19],"secretion":[5,20],"leading":[6],"to":[7,85,126,167,269],"the":[8,25,44,70,74,92,99,140,144,149,154,242],"production":[9,156],"of":[10,31,49,56,76,91,95,101,105,110,143,151,157,177,204,237],"polycystic":[11,119,145,196,259],"ovaries":[12,120,133,146,161,197,202,252],"(Ferriman,":[13],"1960)":[14],";":[15],"all":[16],"may":[21,39],"have":[22,63],"disappeared":[23],"in":[24,51,69,98,172,193,209,219],"more":[26,254],"severely":[27],"affected":[28],"patients.The":[29],"development":[30],"sensitive":[32],"and":[33,192],"precise":[34,88],"radio-immunological":[35],"assays":[36],"for":[37],"gonadotrophins":[38],"shed":[40],"some":[41],"light":[42],"on":[43],"problem":[45],"before":[46],"long.The":[47],"incidence":[48],"conception":[50,135],"our":[52,66],"series":[53],"(9":[54],"out":[55],"41)":[57],"is":[58,82,113,169,207],"higher":[59],"than":[60,128,179,218,256],"we":[61],"would":[62,108],"anticipated":[64],"from":[65],"previous":[67],"experiences":[68],"field.This":[71],"has":[72],"been":[73],"experience":[75],"many":[77],"other":[78],"workers":[79],"(Greenblatt,":[80],"1966).It":[81],"not":[83,245,263],"possible":[84],"make":[86],"a":[87,122,230,233],"statistical":[89],"assessment":[90],"comparative":[93],"value":[94],"this":[96,190,226],"drug":[97],"absence":[100],"control":[102],"data.The":[103],"provision":[104],"such":[106],"data":[107],"be":[109,138],"great":[111],"interest.It":[112],"odd":[114],"that":[115],"while":[116],"patients":[117,173,194,210],"with":[118,130,148,174,185,195,199,211,250,258],"show":[121],"better":[123,171,208],"ovulatory":[124,165],"response":[125,166],"clomiphene":[127,168],"those":[129,186,200,220,257],"normal-":[131],"sized":[132],"their":[134],"rate":[136],"should":[137],"lower.Perhaps":[139],"thickened":[141],"capsules":[142],"interfere":[147],"release":[150],"ova,":[152],"or":[153],"increased":[155],"androgen":[158],"by":[159,229],"these":[160],"impairs":[162],"nidation.":[163],"SummaryThe":[164],"significantly":[170],"menstrual":[175],"cycles":[176,188],"less":[178],"six":[180],"months'":[181],"dura-":[182],"tion":[183],"compared":[184,198],"whose":[187,201,221],"exceed":[189],"figure,":[191],"are":[203],"normal":[205],"size.It":[206],"basal":[212],"oestrogen":[213],"excretions":[214],"exceeding":[215],"21":[216],",ug./24hours":[217],"excretion":[222],"levels":[223],"fall":[224],"below":[225],"figure":[227],"(obtained":[228],"method":[231],"having":[232],"nonspecific":[234],"background":[235],"fluorescence":[236],"10":[238],"xug./24":[239],"hours),":[240],"though":[241],"difference":[243,261],"does":[244,262],"quite":[246,264],"reach":[247,265],"formal":[248,266],"significance.Patients":[249],"normal-sized":[251],"conceive":[253],"readily":[255],"ovaries.The":[260],"significance.We":[267],"wish":[268],"thank":[270],"Dr.":[271],"D.":[272]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}