{"id":"https://openalex.org/W1963572265","doi":"https://doi.org/10.1111/j.1600-0765.2007.01021.x","title":"Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide\u2010induced alveolar bone resorption","display_name":"Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide\u2010induced alveolar bone resorption","publication_year":2007,"publication_date":"2007-12-12","ids":{"openalex":"https://openalex.org/W1963572265","doi":"https://doi.org/10.1111/j.1600-0765.2007.01021.x","mag":"1963572265","pmid":"https://pubmed.ncbi.nlm.nih.gov/18086145"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0765.2007.01021.x","doi":"https://doi.org/10.1111/j.1600-0765.2007.01021.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0765.2007.01021.x","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1963572265"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tohoku.repo.nii.ac.jp/record/91061/files/D1H19466.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100403636","display_name":"Rui Chen","orcid":"https://orcid.org/0000-0002-3589-9103","observed_orcids":["https://orcid.org/0000-0002-3589-9103"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rui Chen","raw_affiliation_strings":["Division of Oral Dysfunction Science, Department of Oral Health and Developmenet Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan","Division of Oral Dysfunction Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oral Dysfunction Science, Department of Oral Health and Developmenet Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Division of Oral Dysfunction Science","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049968620","display_name":"Hiroyuki Kanzaki","orcid":"https://orcid.org/0000-0003-3473-1218","observed_orcids":["https://orcid.org/0000-0003-3473-1218"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kanzaki","raw_affiliation_strings":["Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103201082","display_name":"Mirei Chiba","orcid":"https://orcid.org/0000-0002-7470-7282","observed_orcids":["https://orcid.org/0000-0002-7470-7282"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mirei Chiba","raw_affiliation_strings":["Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057308217","display_name":"Makoto Nishimura","orcid":"https://orcid.org/0000-0001-8658-3582","observed_orcids":["https://orcid.org/0000-0001-8658-3582","https://orcid.org/0009-0008-9180-4851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Makoto Nishimura","raw_affiliation_strings":["Division of Oral Dysfunction Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oral Dysfunction Science","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028746976","display_name":"Reiko Kanzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Kanzaki","raw_affiliation_strings":["Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090131358","display_name":"Kaoru Igarashi","orcid":"https://orcid.org/0000-0003-0017-357X","observed_orcids":["https://orcid.org/0000-0003-0017-357X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaoru Igarashi","raw_affiliation_strings":["Division of Oral Dysfunction Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oral Dysfunction Science","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.2132,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.45295413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"43","issue":"2","first_page":"237","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.1615999937057495,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.8199999928474426},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.9670000076293945},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/periodontium","display_name":"periodontium","score":0.6140000224113464},{"id":"https://openalex.org/keywords/experimental-periodontitis","display_name":"experimental periodontitis","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.8965350389480591},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.8782870769500732},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.8727348446846008},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6936790943145752},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.6892833709716797},{"id":"https://openalex.org/C41868710","wikidata":"https://www.wikidata.org/wiki/Q540092","display_name":"Periodontal fiber","level":2,"score":0.6768596172332764},{"id":"https://openalex.org/C2777894202","wikidata":"https://www.wikidata.org/wiki/Q848382","display_name":"Cementum","level":3,"score":0.5378484129905701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4996354579925537},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.4979829788208008},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.48734650015830994},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.4699575901031494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46061253547668457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39703625440597534},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29485243558883667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2936711013317108},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.26654741168022156},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.24663186073303223},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.04848378896713257}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029082","descriptor_name":"Sendai virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-0765.2007.01021.x","doi":"https://doi.org/10.1111/j.1600-0765.2007.01021.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0765.2007.01021.x","pdf_url":null,"source":{"id":"https://openalex.org/S195000414","display_name":"Journal of Periodontal Research","issn_l":"0022-3484","issn":["0022-3484","1600-0765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Periodontal Research","raw_type":"journal-article"},{"id":"pmid:18086145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18086145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of periodontal research","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00918:0000507955","doi":null,"is_oa":true,"landing_page_url":"https://tohoku.repo.nii.ac.jp/records/91061","pdf_url":"https://tohoku.repo.nii.ac.jp/record/91061/files/D1H19466.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"other"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00918:0000507955","doi":null,"is_oa":true,"landing_page_url":"https://tohoku.repo.nii.ac.jp/records/91061","pdf_url":"https://tohoku.repo.nii.ac.jp/record/91061/files/D1H19466.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"other"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963572265.pdf","grobid_xml":"https://content.openalex.org/works/W1963572265.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W101321234","https://openalex.org/W1910581214","https://openalex.org/W1966119864","https://openalex.org/W1971195407","https://openalex.org/W1976498839","https://openalex.org/W1985148995","https://openalex.org/W1995616953","https://openalex.org/W1999235557","https://openalex.org/W2000647744","https://openalex.org/W2013380492","https://openalex.org/W2028077169","https://openalex.org/W2033793521","https://openalex.org/W2055166353","https://openalex.org/W2059030477","https://openalex.org/W2061479972","https://openalex.org/W2071098531","https://openalex.org/W2079588364","https://openalex.org/W2081147917","https://openalex.org/W2081527623","https://openalex.org/W2093252878","https://openalex.org/W2093424805","https://openalex.org/W2093664855","https://openalex.org/W2095772076","https://openalex.org/W2100751439","https://openalex.org/W2111745826","https://openalex.org/W2128845100","https://openalex.org/W2144345929","https://openalex.org/W2149868323","https://openalex.org/W2165435958","https://openalex.org/W2168382396","https://openalex.org/W2168752929","https://openalex.org/W2169296653","https://openalex.org/W3205519421"],"related_works":["https://openalex.org/W1998770101","https://openalex.org/W2361533116","https://openalex.org/W2168752929","https://openalex.org/W2048961393","https://openalex.org/W2095182741","https://openalex.org/W3155665196","https://openalex.org/W2358775916","https://openalex.org/W2067997394","https://openalex.org/W2367408990","https://openalex.org/W1965861044"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,78],"OBJECTIVE:":[2],"Osteoclastogenesis":[3],"is":[4,17],"primarily":[5],"activated":[6],"by":[7,19,62],"receptor":[8],"activator":[9],"of":[10,87,96,112,135],"nuclear":[11],"factor":[12],"kappaB":[13],"ligand":[14],"(RANKL)":[15],"and":[16,37,68,105,155,177],"inhibited":[18,34,175],"osteoprotegerin":[20],"(OPG).":[21],"A":[22],"previous":[23],"study":[24],"demonstrated":[25],"that":[26,49],"local":[27,50],"OPG":[28,51,120,149,153,160],"gene":[29,52,150,161,170],"transfer":[30,53,151,162,171],"to":[31,54,172],"periodontal":[32,75,133,145,173,184],"tissue":[33,134,174],"RANKL-mediated":[35],"osteoclastogenesis":[36,67,156,176],"experimental":[38,74,183],"tooth":[39],"movement.":[40],"In":[41],"the":[42,47,55,93,97,103,131,136],"present":[43],"study,":[44],"we":[45],"tested":[46],"hypothesis":[48],"periodontium":[56],"can":[57],"neutralize":[58],"RANKL":[59],"activity":[60],"induced":[61,143,152],"lipopolysaccharide":[63,88],"injection,":[64],"thereby":[65],"inhibiting":[66],"diminishing":[69],"alveolar":[70,165,178],"bone":[71,146,166,179],"resorption":[72,180],"in":[73,92,181],"disease.":[76,185],"MATERIAL":[77],"METHODS:":[79],"Seven-week-old":[80],"male":[81],"Wistar":[82],"rats":[83],"received":[84],"an":[85],"injection":[86,142],"or":[89,124],"phosphate-buffered":[90],"saline":[91],"palatal":[94,132],"gingiva":[95],"upper":[98,137],"first":[99,138],"molars":[100],"on":[101],"both":[102],"right":[104],"left":[106],"sides.":[107],"An":[108],"inactivated":[109],"haemagglutinating":[110],"virus":[111],"Japan":[113],"(HVJ)":[114],"envelope":[115],"vector":[116,126],"containing":[117],"a":[118],"mouse":[119],"expression":[121],"plasmid":[122],"[pcDNA3.1(+)-mOPG]":[123],"mock":[125],"was":[127,157],"injected":[128],"periodically":[129],"into":[130],"molars.":[139],"RESULTS:":[140],"Lipopolysaccharide":[141],"severe":[144],"resorption.":[147,167],"Local":[148,159],"production,":[154],"inhibited.":[158],"significantly":[163],"decreased":[164],"CONCLUSION:":[168],"Osteoprotegerin":[169],"lipopolysaccharide-induced":[182]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}