{"id":"https://openalex.org/W1963565705","doi":"https://doi.org/10.1002/hep.1840120512","title":"Human hepatic regenerative stimulator substance: Partial purification and biological characterization of hepatic stimulator substance from human fetal liver cells","display_name":"Human hepatic regenerative stimulator substance: Partial purification and biological characterization of hepatic stimulator substance from human fetal liver cells","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W1963565705","doi":"https://doi.org/10.1002/hep.1840120512","mag":"1963565705","pmid":"https://pubmed.ncbi.nlm.nih.gov/2227812"},"language":"en","primary_location":{"id":"doi:10.1002/hep.1840120512","doi":"https://doi.org/10.1002/hep.1840120512","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.1840120512","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042296452","display_name":"Yao Zhiqiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Zhiqiang","raw_affiliation_strings":["Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yang Weisong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Weisong","raw_affiliation_strings":["Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111514672","display_name":"Zhang Wenbin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Wenbin","raw_affiliation_strings":["Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705998","display_name":"Yong Chen","orcid":"https://orcid.org/0000-0002-3876-0158","observed_orcids":["https://orcid.org/0000-0002-3876-0158"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Yong","raw_affiliation_strings":["Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yang Fengyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Fengyi","raw_affiliation_strings":["Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, the Second (TONGDU) Affiliated Hospital, the Fourth Military Medical University, Xi'an, People's Republic of China","institution_ids":["https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042296452"],"corresponding_institution_ids":["https://openalex.org/I9916479"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":1.3685,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84378947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"5","first_page":"1144","last_page":"1151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-liver-cells","display_name":"fetal liver cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/partial-purification","display_name":"partial purification","score":0.6380000114440918},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hepatocyte-transplantation","display_name":"hepatocyte transplantation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/species-specificity","display_name":"species specificity","score":0.4169999957084656},{"id":"https://openalex.org/keywords/protease-sensitivity","display_name":"protease sensitivity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2911118192","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Fulminant hepatic failure","level":4,"score":0.7775688171386719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6275057196617126},{"id":"https://openalex.org/C2778433245","wikidata":"https://www.wikidata.org/wiki/Q7978039","display_name":"Weanling","level":2,"score":0.6064344644546509},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5934298038482666},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5622086524963379},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5304965972900391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4791247546672821},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.434383749961853},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.410504013299942},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.340190589427948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30004769563674927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26985740661621094},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.17105957865715027},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14736241102218628},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.11405369639396667},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.10872405767440796},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09422338008880615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08932077884674072},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005688","descriptor_name":"Galactosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.1840120512","doi":"https://doi.org/10.1002/hep.1840120512","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.1840120512","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:2227812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2227812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W167338112","https://openalex.org/W1485233538","https://openalex.org/W1490154674","https://openalex.org/W1520458323","https://openalex.org/W1586072285","https://openalex.org/W1608742253","https://openalex.org/W1750535841","https://openalex.org/W1906197854","https://openalex.org/W1978745104","https://openalex.org/W1986355683","https://openalex.org/W1989297142","https://openalex.org/W1989943143","https://openalex.org/W2001104440","https://openalex.org/W2047642287","https://openalex.org/W2048367533","https://openalex.org/W2049623337","https://openalex.org/W2052674146","https://openalex.org/W2062870849","https://openalex.org/W2077034553","https://openalex.org/W2085023954","https://openalex.org/W2092985701","https://openalex.org/W2127510291","https://openalex.org/W2150662486","https://openalex.org/W2152737761","https://openalex.org/W2157510423","https://openalex.org/W2173859365","https://openalex.org/W2247149472","https://openalex.org/W2271317252","https://openalex.org/W2337935976","https://openalex.org/W2409795449","https://openalex.org/W2412196813","https://openalex.org/W2431098381","https://openalex.org/W2608256706"],"related_works":["https://openalex.org/W2409421206","https://openalex.org/W2115596719","https://openalex.org/W2176742052","https://openalex.org/W2001104440","https://openalex.org/W2429885302","https://openalex.org/W2271317252","https://openalex.org/W46770346","https://openalex.org/W1974680006","https://openalex.org/W2173859365","https://openalex.org/W2178975520"],"abstract_inverted_index":{"Current":[0],"support":[1],"or":[2,89],"replacement":[3],"therapies":[4],"for":[5],"fulminant":[6],"acute":[7],"hepatic":[8,18,54,66,79,108,184,194,204],"failure":[9],"are":[10],"frequently":[11],"very":[12],"disappointing.":[13],"In":[14],"this":[15],"study,":[16],"human":[17,27,172,183,193,203],"stimulator":[19,51,55,67,185,195,205],"substance--a":[20],"liver-specific":[21],"growth":[22,50],"factor--was":[23],"partially":[24],"purified":[25,42],"from":[26],"fetal":[28,174],"liver":[29],"cells":[30],"and":[31,63,147,198],"characterized":[32],"by":[33],"its":[34],"biological":[35],"effects.":[36],"Almost":[37],"70-fold":[38],"protein":[39],"content":[40],"was":[41,156],"with":[43,163],"an":[44],"approximately":[45],"80-fold":[46],"increase":[47,74],"in":[48,98,110],"specific":[49],"activity.":[52],"Human":[53,65],"substance":[56,68,186,196,206],"proved":[57],"to":[58,72],"be":[59],"heat-stable,":[60],"protease-sensitive,":[61],"organ-specific":[62],"species-nonspecific.":[64],"produced":[69],"a":[70],"two-":[71],"threefold":[73],"of":[75,96,102,118,166,171,182,190,201],"3H-thymidine":[76],"incorporation":[77],"into":[78,84],"DNA":[80],"when":[81,158],"injected":[82,162],"intraperitoneally":[83],"growing":[85],"weanling":[86],"mice":[87],"(nonhepatectomized)":[88],"regenerating":[90],"rats":[91,111,160],"(34%":[92],"hepatectomy).":[93],"The":[94],"effects":[95],"hHSS":[97],"reversing":[99],"the":[100,159],"lethality":[101],"D-galactosamine":[103],"(1.6":[104],"gm/kg":[105],"body":[106],"weight)-induced":[107],"necrosis":[109],"were":[112,161],"further":[113],"evaluated.":[114],"A":[115],"survival":[116],"rate":[117],"4%":[119],"(n":[120,124,132,140,149],"=":[121,125,133,141,150],"24),":[122],"41%":[123],"12,":[126,134],"p":[127,135,143,152],"less":[128,136,144],"than":[129,137,145,154],"0.05),":[130,138],"33%":[131],"31%":[139],"13,":[142],"0.05)":[146,155],"18%":[148],"11,":[151],"greater":[153],"observed":[157],"4":[164,169,180],"ml":[165,170,181,189,200],"saline":[167],"intraperitoneally,":[168,179,187],"intact":[173],"hepatocytes":[175],"(2.4":[176],"x":[177],"10(8]":[178],"2":[188],"twofold":[191],"concentrated":[192],"intravenously":[197],"1":[199],"fourfold":[202],"intramuscularly,":[207],"respectively,":[208],"20":[209],"hr":[210],"after":[211],"poisoning.(ABSTRACT":[212],"TRUNCATED":[213],"AT":[214],"250":[215],"WORDS)":[216]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
