{"id":"https://openalex.org/W1963559816","doi":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","title":"Adverse haemodynamic effects of high\u2010dose aprotinin in a paediatric cardiac surgical patient","display_name":"Adverse haemodynamic effects of high\u2010dose aprotinin in a paediatric cardiac surgical patient","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W1963559816","doi":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","mag":"1963559816","pmid":"https://pubmed.ncbi.nlm.nih.gov/1700640"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2044.1990.tb14571.x","doi":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1990.tb14571.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1990.tb14571.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111671436","display_name":"Hubert Bohrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. B\u00d6HRER","raw_affiliation_strings":["Department of Anaesthesia, University of Heidelberg, West Germany","H. B\u00f6hrer, MD, DEAA, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesia, University of Heidelberg, West Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"H. B\u00f6hrer, MD, DEAA, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111925177","display_name":"A. Bach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. BACH","raw_affiliation_strings":["A. Bach, MD, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. Bach, MD, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039693820","display_name":"F. Fleischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. FLEISCHER","raw_affiliation_strings":["F. Fleischer, MD, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Fleischer, MD, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110987954","display_name":"J Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. LANG","raw_affiliation_strings":["J. Lang, MD, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Lang, MD, Department of Anaesthesia, University of Heidelberg, Im Neuenheimer Feld 110, D-6900 Heidelberg, West Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":4970,"currency":"USD","value_usd":4970},"apc_paid":null,"fwci":3.4999,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.92726846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"10","first_page":"853","last_page":"854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8930000066757202},{"id":"https://openalex.org/keywords/flushing","display_name":"flushing","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pediatric-cardiac-surgery","display_name":"pediatric cardiac surgery","score":0.9309999942779541},{"id":"https://openalex.org/keywords/intraoperative-blood-loss","display_name":"intraoperative blood loss","score":0.7879999876022339},{"id":"https://openalex.org/keywords/postoperative-blood-loss","display_name":"postoperative blood loss","score":0.8700000047683716},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cardiovascular-instability","display_name":"cardiovascular instability","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9854704141616821},{"id":"https://openalex.org/C2780799893","wikidata":"https://www.wikidata.org/wiki/Q418625","display_name":"Aprotinin","level":2,"score":0.9150243997573853},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.668548583984375},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6328549385070801},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6006820797920227},{"id":"https://openalex.org/C2778520758","wikidata":"https://www.wikidata.org/wiki/Q3443277","display_name":"Flushing","level":2,"score":0.5258334875106812},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.48910123109817505},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.4714542329311371},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34550046920776367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2042917013168335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2044.1990.tb14571.x","doi":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1990.tb14571.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},{"id":"pmid:1700640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1700640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2044.1990.tb14571.x","doi":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.1990.tb14571.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1990.tb14571.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963559816.pdf","grobid_xml":"https://content.openalex.org/works/W1963559816.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1967523846","https://openalex.org/W1987347324","https://openalex.org/W1997068213","https://openalex.org/W2009699612","https://openalex.org/W2017118779","https://openalex.org/W2020624709","https://openalex.org/W2047045638","https://openalex.org/W2070586531","https://openalex.org/W2079656189","https://openalex.org/W2156910916","https://openalex.org/W2253816243","https://openalex.org/W2341772947","https://openalex.org/W2409962522"],"related_works":["https://openalex.org/W2040937372","https://openalex.org/W2068266143","https://openalex.org/W2079007124","https://openalex.org/W4255448282","https://openalex.org/W2025999616","https://openalex.org/W2322665250","https://openalex.org/W1977572546","https://openalex.org/W2313606424","https://openalex.org/W2443395670","https://openalex.org/W1561238274"],"abstract_inverted_index":{"High-dose":[0],"aprotinin":[1],"for":[2],"reduction":[3],"of":[4],"intra-":[5],"and":[6,15,28],"postoperative":[7],"blood":[8],"loss":[9],"was":[10,31,35],"associated":[11],"with":[12,26],"profound":[13],"hypotension":[14],"flushing":[16],"in":[17],"a":[18],"3.5-year-old":[19],"child":[20],"who":[21],"underwent":[22],"cardiac":[23],"surgery.":[24],"Treatment":[25],"noradrenaline":[27],"intravenous":[29],"fluid":[30],"required.":[32],"Cardiovascular":[33],"stability":[34],"restored":[36],"after":[37],"10":[38],"minutes.":[39]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
