{"id":"https://openalex.org/W1963554302","doi":"https://doi.org/10.1093/neuonc/nou255.4","title":"ET-04 * MEBENDAZOLE IS EFFICACIOUS IN DIVERSE MEDULLOBLASTOMA TUMOR MODELS AND INHIBITS TUMOR ANGIOGENESIS","display_name":"ET-04 * MEBENDAZOLE IS EFFICACIOUS IN DIVERSE MEDULLOBLASTOMA TUMOR MODELS AND INHIBITS TUMOR ANGIOGENESIS","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W1963554302","doi":"https://doi.org/10.1093/neuonc/nou255.4","mag":"1963554302"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nou255.4","doi":"https://doi.org/10.1093/neuonc/nou255.4","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/nou255.4","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/suppl_5/v79/3599405/nou255.4.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/suppl_5/v79/3599405/nou255.4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R. Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Bai","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083149638","display_name":"Verena Staedtke","orcid":"https://orcid.org/0000-0002-7874-5585","observed_orcids":["https://orcid.org/0000-0002-7874-5585"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Staedtke","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049524331","display_name":"Charles M. Rudin","orcid":"https://orcid.org/0000-0001-5204-3465","observed_orcids":["https://orcid.org/0000-0001-5204-3465"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Rudin","raw_affiliation_strings":["#N#            2Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#            2Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089509820","display_name":"Fred Bunz","orcid":"https://orcid.org/0000-0003-0878-1553","observed_orcids":["https://orcid.org/0000-0003-0878-1553"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Bunz","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057847362","display_name":"Gregory Joseph Riggins","orcid":"https://orcid.org/0000-0002-4538-0436","observed_orcids":["https://orcid.org/0000-0002-4538-0436","https://orcid.org/0000-0002-9634-8524"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Riggins","raw_affiliation_strings":["1Johns Hopkins University, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Johns Hopkins University, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"suppl 5","first_page":"v79","last_page":"v79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mebendazole","display_name":"mebendazole","score":0.8700000047683716},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vegfr-2-inhibition","display_name":"VEGFR-2 inhibition","score":0.8669999837875366},{"id":"https://openalex.org/keywords/shh-medulloblastoma","display_name":"SHH medulloblastoma","score":0.8259999752044678},{"id":"https://openalex.org/keywords/group-3-medulloblastoma","display_name":"Group 3 medulloblastoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ptch1-mutation","display_name":"PTCH1 mutation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.7450000047683716},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.9185240864753723},{"id":"https://openalex.org/C2779061029","wikidata":"https://www.wikidata.org/wiki/Q422194","display_name":"Mebendazole","level":2,"score":0.8019737005233765},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6189165115356445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48970773816108704},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41444841027259827},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35773536562919617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17465266585350037},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/nou255.4","doi":"https://doi.org/10.1093/neuonc/nou255.4","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/nou255.4","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/suppl_5/v79/3599405/nou255.4.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4218137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4218137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/nou255.4","doi":"https://doi.org/10.1093/neuonc/nou255.4","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/nou255.4","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/suppl_5/v79/3599405/nou255.4.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1963554302.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068095941","https://openalex.org/W2437378177","https://openalex.org/W102352224","https://openalex.org/W2026535531","https://openalex.org/W2415344201","https://openalex.org/W2129563366","https://openalex.org/W2401721453","https://openalex.org/W2415240345","https://openalex.org/W2416286154","https://openalex.org/W1994782072"],"abstract_inverted_index":{"Medulloblastoma":[0],"is":[1],"the":[2,16,42,68,78,98,104,118,124],"leading":[3],"cause":[4],"of":[5,37,70,103,127],"cancer":[6],"death":[7],"in":[8,23,31,59,106,129,132],"children.":[9],"Surgery,":[10],"radiotherapy":[11],"and":[12,33,81,85,122,131],"chemotherapy":[13],"regimens":[14],"are":[15],"current":[17],"standard":[18],"for":[19,145],"treatment.":[20],"While":[21],"effective":[22],"most":[24],"patients,":[25],"those":[26],"have":[27],"long-term":[28],"neurological":[29],"sequelae":[30],"survivors,":[32],"a":[34,91,141],"significant":[35,56],"fraction":[36],"patients":[38],"still":[39],"succumb":[40],"to":[41,97],"disease.":[43],"In":[44],"this":[45],"study,":[46],"we":[47],"found":[48],"that":[49,110,137],"mebendazole":[50],"(MBZ),":[51],"an":[52],"FDA-approved":[53],"antiparasitic,":[54],"demonstrated":[55],"anti-tumor":[57],"efficacy":[58],"etiologically":[60],"distinct":[61],"medulloblastoma":[62,93,146],"mouse":[63],"models.":[64],"MBZ":[65,111,138],"significantly":[66],"improved":[67],"survival":[69],"mice":[71],"with":[72,94,147],"orthotopic":[73],"xenograft":[74],"tumors":[75,108],"derived":[76],"from":[77],"SHH":[79],"group":[80,82],"3":[83],"medulloblastomas":[84],"was":[86],"also":[87],"highly":[88,142],"efficacious":[89],"against":[90],"PTCH1-mutant":[92],"acquired":[95],"resistance":[96],"SMO":[99],"inhibitor":[100],"vismodgib.":[101],"Analysis":[102],"vasculature":[105],"rodent":[107],"revealed":[109],"selectively":[112],"inhibited":[113,123],"tumor":[114],"angiogenesis":[115,149],"but":[116],"not":[117],"normal":[119],"brain":[120],"vasculature,":[121],"kinase":[125],"activity":[126],"VEGFR2":[128],"vitro":[130],"vivo.":[133],"This":[134],"study":[135],"demonstrates":[136],"could":[139],"be":[140],"promising":[143],"therapeutic":[144],"anti-":[148],"activity.":[150]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}