{"id":"https://openalex.org/W1963554091","doi":"https://doi.org/10.1016/j.metabol.2011.08.006","title":"Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters","display_name":"Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters","publication_year":2011,"publication_date":"2011-10-17","ids":{"openalex":"https://openalex.org/W1963554091","doi":"https://doi.org/10.1016/j.metabol.2011.08.006","mag":"1963554091","pmid":"https://pubmed.ncbi.nlm.nih.gov/22001333"},"language":"en","primary_location":{"id":"doi:10.1016/j.metabol.2011.08.006","doi":"https://doi.org/10.1016/j.metabol.2011.08.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.metabol.2011.08.006","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100449751","display_name":"Zhu Chen","orcid":"https://orcid.org/0000-0002-9974-0716","observed_orcids":["https://orcid.org/0000-0002-9974-0716","https://orcid.org/0000-0001-8827-3342"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhu Chen","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA. zhu_chen@merck.com","Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA. zhu_chen@merck.com","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887128","display_name":"Shengping Wang","orcid":"https://orcid.org/0000-0002-4245-310X","observed_orcids":["https://orcid.org/0000-0002-4245-310X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng-ping Wang","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054610785","display_name":"Mihajlo L. Krsmanovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mihajlo L. Krsmanovic","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091723829","display_name":"Jose M. Castro\u2010Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Castro-Perez","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056074013","display_name":"Karen Gagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Gagen","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042312820","display_name":"Vivienne Mendoza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivienne Mendoza","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080508390","display_name":"Ray Rosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray Rosa","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109486625","display_name":"Vinit Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinit Shah","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034657918","display_name":"Timothy He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy He","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032846552","display_name":"Steven J. Stout","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve J. Stout","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023825212","display_name":"Neil S. M. Geoghagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil S. Geoghagen","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764633","display_name":"Sang Hyub Lee","orcid":"https://orcid.org/0000-0003-2174-9726","observed_orcids":["https://orcid.org/0000-0003-2174-9726"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang H. Lee","raw_affiliation_strings":["Bioanalytical, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioanalytical, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113503473","display_name":"David G. McLaren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. McLaren","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041413974","display_name":"Liangsu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liangsu Wang","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073022316","display_name":"Thomas P. Roddy","orcid":"https://orcid.org/0009-0005-1143-6840","observed_orcids":["https://orcid.org/0009-0005-1143-6840"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas P. Roddy","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021590941","display_name":"Andrew S. Plump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S. Plump","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069133442","display_name":"Brian K. Hubbard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian K. Hubbard","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045269156","display_name":"Christopher J. Sinz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Sinz","raw_affiliation_strings":["Exploratory Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073513179","display_name":"Douglas G. Johns","orcid":"https://orcid.org/0000-0002-8726-8514","observed_orcids":["https://orcid.org/0000-0002-8726-8514"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas G. Johns","raw_affiliation_strings":["Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100449751"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":2.9435,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.89929486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"61","issue":"4","first_page":"470","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lcat","display_name":"lecithin:cholesterol acyltransferase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/small-molecule-activators","display_name":"small molecule activators","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9589999914169312},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.8980000019073486},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vldl-cholesterol","display_name":"VLDL cholesterol","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.8190000057220459},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2779564620","wikidata":"https://www.wikidata.org/wiki/Q241595","display_name":"Lecithin","level":2,"score":0.7195056676864624},{"id":"https://openalex.org/C964641","wikidata":"https://www.wikidata.org/wiki/Q424716","display_name":"Lecithin\u2014cholesterol acyltransferase","level":4,"score":0.6867451667785645},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.6495097875595093},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6000356674194336},{"id":"https://openalex.org/C2775970874","wikidata":"https://www.wikidata.org/wiki/Q2609152","display_name":"Acyltransferase","level":3,"score":0.5871443748474121},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5609731078147888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4814166724681854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4642176628112793},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4524496793746948},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.43560516834259033},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.43484562635421753},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3463394045829773},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3287493586540222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31560805439949036}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007862","descriptor_name":"Phosphatidylcholine-Sterol O-Acyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013830","descriptor_name":"Thiadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013830","descriptor_name":"Thiadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.metabol.2011.08.006","doi":"https://doi.org/10.1016/j.metabol.2011.08.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.metabol.2011.08.006","pdf_url":null,"source":{"id":"https://openalex.org/S119661813","display_name":"Metabolism","issn_l":"0026-0495","issn":["0026-0495","1532-8600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism","raw_type":"journal-article"},{"id":"pmid:22001333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22001333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolism: clinical and experimental","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1552121147","https://openalex.org/W1947043095","https://openalex.org/W1974176003","https://openalex.org/W1986897872","https://openalex.org/W1988162785","https://openalex.org/W1991272474","https://openalex.org/W1992547735","https://openalex.org/W1996565558","https://openalex.org/W1997601303","https://openalex.org/W2004447015","https://openalex.org/W2008930714","https://openalex.org/W2012504949","https://openalex.org/W2017002005","https://openalex.org/W2021285579","https://openalex.org/W2030554449","https://openalex.org/W2047408830","https://openalex.org/W2054497136","https://openalex.org/W2066236038","https://openalex.org/W2070554153","https://openalex.org/W2094448886","https://openalex.org/W2094768566","https://openalex.org/W2097883007","https://openalex.org/W2104416984","https://openalex.org/W2106571453","https://openalex.org/W2113504642","https://openalex.org/W2121714459","https://openalex.org/W2127432329","https://openalex.org/W2139751443","https://openalex.org/W2141194988","https://openalex.org/W2152311269","https://openalex.org/W2155214511","https://openalex.org/W2158394544","https://openalex.org/W2161615797","https://openalex.org/W2188620533","https://openalex.org/W2398093727","https://openalex.org/W2955306499","https://openalex.org/W4240652435","https://openalex.org/W6764863195"],"related_works":["https://openalex.org/W2588371671","https://openalex.org/W3175065780","https://openalex.org/W4401601506","https://openalex.org/W4381594573","https://openalex.org/W3089313882","https://openalex.org/W3094343244","https://openalex.org/W6898928087","https://openalex.org/W4396591918","https://openalex.org/W2621123160","https://openalex.org/W2053085580"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
