{"id":"https://openalex.org/W1963542258","doi":"https://doi.org/10.1158/1078-0432.ccr-10-1587","title":"Nutlin-3a Is a Potential Therapeutic for Ewing Sarcoma","display_name":"Nutlin-3a Is a Potential Therapeutic for Ewing Sarcoma","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W1963542258","doi":"https://doi.org/10.1158/1078-0432.ccr-10-1587","mag":"1963542258","pmid":"https://pubmed.ncbi.nlm.nih.gov/21098696"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-10-1587","doi":"https://doi.org/10.1158/1078-0432.ccr-10-1587","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-10-1587","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/17/3/494/2000979/494.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/17/3/494/2000979/494.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077917060","display_name":"Kathleen I. Pishas","orcid":"https://orcid.org/0000-0001-7863-807X","observed_orcids":["https://orcid.org/0000-0001-7863-807X"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathleen I. Pishas","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036264210","display_name":"Fares Al\u2010Ejeh","orcid":"https://orcid.org/0000-0002-1553-0077","observed_orcids":["https://orcid.org/0000-0002-1553-0077"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Fares Al-Ejeh","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011750139","display_name":"Irene Zinonos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Irene Zinonos","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108041326","display_name":"Raman Kumar","orcid":"https://orcid.org/0000-0001-7976-8386","observed_orcids":["https://orcid.org/0000-0001-7976-8386"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Raman Kumar","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075623882","display_name":"Andreas Evdokiou","orcid":"https://orcid.org/0000-0001-8321-9806","observed_orcids":["https://orcid.org/0000-0001-8321-9806"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andreas Evdokiou","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021075431","display_name":"Michael Paul Brown","orcid":"https://orcid.org/0000-0002-5796-1932","observed_orcids":["https://orcid.org/0000-0002-5796-1932","https://orcid.org/0000-0002-0495-7315"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael P. Brown","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061371974","display_name":"David Frederick Callen","orcid":"https://orcid.org/0000-0002-6189-9991","observed_orcids":["https://orcid.org/0000-0002-6189-9991"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David F. Callen","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020128416","display_name":"Paul Matthew Neilsen","orcid":"https://orcid.org/0000-0001-7937-3675","observed_orcids":["https://orcid.org/0000-0001-7937-3675"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I4210154468","display_name":"Hanson Institute","ror":"https://ror.org/047kx5j58","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210154468"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul M. Neilsen","raw_affiliation_strings":["Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Sarcoma Research Group and 2Breast Cancer Genetics Group, Discipline of Medicine, University of Adelaide and Hanson Institute Adelaide, South Australia; 3Discipline of Orthopaedics and Trauma, University of Adelaide, Royal Adelaide Hospital and Hanson Institute, 4Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, and 5Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, and School of Medicine, University of Adelaide, Adelaide, South Australia; 6Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I4210154468","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0338,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.96016166,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"494","last_page":"504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nutlin-3a","display_name":"Nutlin-3a","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7009999752044678},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mdm4","display_name":"MDM4","score":0.8939999938011169},{"id":"https://openalex.org/keywords/p53-dependent-apoptosis","display_name":"p53-dependent apoptosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7379999756813049},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.7730000019073486},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.9599999785423279},{"id":"https://openalex.org/keywords/wild-type-p53","display_name":"wild-type p53","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.7776305079460144},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7494348287582397},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7119922637939453},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6285659074783325},{"id":"https://openalex.org/C2777586341","wikidata":"https://www.wikidata.org/wiki/Q1138580","display_name":"Ewing's sarcoma","level":3,"score":0.6032648682594299},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.5377500057220459},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5241082906723022},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5230334997177124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4858526885509491},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.4607260227203369},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3178969621658325},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2469133734703064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23316743969917297},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19472092390060425},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06055951118469238},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/1078-0432.ccr-10-1587","doi":"https://doi.org/10.1158/1078-0432.ccr-10-1587","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-10-1587","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/17/3/494/2000979/494.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:21098696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21098696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:acquire.cqu.edu.au:cqu:16658","doi":null,"is_oa":false,"landing_page_url":"http://hdl.cqu.edu.au/10018/1249972","pdf_url":null,"source":{"id":"https://openalex.org/S4306400635","display_name":"Acquire (CQUniversity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74899385","host_organization_name":"Central Queensland University","host_organization_lineage":["https://openalex.org/I74899385"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pishas, KI, Al-Ejeh, F, Zinonos, I, Kumar, R, Evdokiou, A, Brown, MP, Callen, DF, Neilsen, PM, (2011). Nutlin-3a is a potential therapeutic for Ewing sarcoma. Clinical Cancer Research, Vol. 17, No. 3, p. 494-504 http://dx.doi.org/10.1158/1078-0432.CCR-10-1587","raw_type":"journal article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/63612","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/63612","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1158/1078-0432.CCR-10-1587","raw_type":"Journal article"},{"id":"pmh:oai:figshare.com:article/13441430","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Nutlin-3a_is_a_potential_therapeutic_for_Ewing_sarcoma/13441430","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-10-1587","doi":"https://doi.org/10.1158/1078-0432.ccr-10-1587","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-10-1587","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/17/3/494/2000979/494.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963542258.pdf","grobid_xml":"https://content.openalex.org/works/W1963542258.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W6381430","https://openalex.org/W1650797637","https://openalex.org/W1967488943","https://openalex.org/W1981067307","https://openalex.org/W1997528060","https://openalex.org/W1997557358","https://openalex.org/W2002352068","https://openalex.org/W2005681966","https://openalex.org/W2012720523","https://openalex.org/W2023967169","https://openalex.org/W2026907678","https://openalex.org/W2042757792","https://openalex.org/W2049133549","https://openalex.org/W2058402966","https://openalex.org/W2060387821","https://openalex.org/W2071555702","https://openalex.org/W2071639789","https://openalex.org/W2075103313","https://openalex.org/W2076147908","https://openalex.org/W2078744165","https://openalex.org/W2082979850","https://openalex.org/W2087408588","https://openalex.org/W2097933346","https://openalex.org/W2100494757","https://openalex.org/W2105155498","https://openalex.org/W2106637101","https://openalex.org/W2109325908","https://openalex.org/W2114103020","https://openalex.org/W2114570899","https://openalex.org/W2128472785","https://openalex.org/W2136182072","https://openalex.org/W2139244380","https://openalex.org/W2141762576","https://openalex.org/W2151033070","https://openalex.org/W2151526351","https://openalex.org/W2153641948","https://openalex.org/W2154783588","https://openalex.org/W2158234992","https://openalex.org/W2163125749","https://openalex.org/W2164115530","https://openalex.org/W2317345315","https://openalex.org/W2403327600","https://openalex.org/W6651173200","https://openalex.org/W6713498034"],"related_works":["https://openalex.org/W1964170886","https://openalex.org/W2080533553","https://openalex.org/W2003463790","https://openalex.org/W2403151587","https://openalex.org/W2076147908","https://openalex.org/W4256229724","https://openalex.org/W2140723802","https://openalex.org/W4366990191","https://openalex.org/W2267202447","https://openalex.org/W2188979247"],"abstract_inverted_index":{"PURPOSE:":[0],"Although":[1],"mutations":[2],"in":[3,8,29,81,87,113,154,164,182],"the":[4,48,102,114,126,145,183,191,211,229],"TP53":[5,27,186],"gene":[6],"occur":[7],"half":[9],"of":[10,15,26,53,72,91,98,105,117,129,139,169,185,194,199,215],"all":[11],"cancers,":[12],"approximately":[13],"90%":[14],"Ewing":[16,30,55,92,118,133,165,178,216,231],"sarcomas":[17,179],"retain":[18],"a":[19,63,82,88,155,174,239],"functional":[20],"wild-type":[21,130,170],"p53.":[22],"The":[23,70,96,137],"low":[24],"frequency":[25],"alterations":[28],"sarcoma":[31,56,93,119,134,166,217,232],"makes":[32],"this":[33,43,245],"tumor":[34],"type":[35],"an":[36],"ideal":[37],"candidate":[38],"for":[39,244],"p53-targeted":[40],"therapies.":[41],"In":[42],"study,":[44],"we":[45],"have":[46],"examined":[47],"molecular":[49],"and":[50,108,152,201],"cellular":[51,213],"responses":[52],"cultured":[54],"cell":[57,78,94,135,167,218],"lines":[58,168,219],"following":[59,220],"exposure":[60,221],"to":[61,74,100,222],"Nutlin-3a,":[62],"recently":[64],"developed":[65],"MDM2":[66,200],"antagonist.":[67],"EXPERIMENTAL":[68],"DESIGN:":[69],"ability":[71],"Nutlin-3a":[73,99,225],"impart":[75],"apoptosis":[76,209],"or":[77],"cycle":[79],"arrest":[80],"p53-dependent":[83,208],"manner":[84],"was":[85,120,125,141,162],"determined":[86],"comprehensive":[89],"panel":[90],"lines.":[95,136],"capacity":[97],"augment":[101],"antitumor":[103],"activity":[104],"MDM4":[106,159],"antagonists":[107],"cytotoxic":[109],"agents":[110],"currently":[111],"used":[112],"clinical":[115],"treatment":[116],"also":[121,142],"investigated.":[122],"RESULTS:":[123],"Apoptosis":[124],"primary":[127,212],"response":[128,214],"p53":[131,171,236],"expressing":[132],"cytotoxicity":[138],"Nultin-3a":[140],"synergistic":[143],"with":[144,228],"chemotherapeutic":[146],"agents,":[147],"vincristine,":[148],"actinomycin":[149],"D,":[150],"doxorubicin,":[151],"etoposide":[153],"concentration-dependent":[156],"manner.":[157],"Significant":[158],"protein":[160],"overexpression":[161],"observed":[163],"status,":[172],"providing":[173],"mechanism":[175],"through":[176],"which":[177],"can":[180,226],"develop":[181],"absence":[184],"alterations.":[187],"This":[188],"study":[189],"provides":[190],"first":[192],"evidence":[193],"synergism":[195],"between":[196],"targeted":[197],"inhibition":[198],"MDM4.":[202],"CONCLUSION:":[203],"Our":[204],"findings":[205],"suggest":[206],"that":[207],"is":[210],"Nutlin-3a.":[223],"Furthermore,":[224],"synergize":[227],"current":[230],"chemotherapy":[233],"protocols,":[234],"suggesting":[235],"activation":[237],"as":[238],"novel":[240],"systemic":[241],"therapeutic":[242],"approach":[243],"disease.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
