{"id":"https://openalex.org/W1963534497","doi":"https://doi.org/10.1097/00000421-198812000-00014","title":"Peripheral Neuropathy and Low Dose Cisplatin","display_name":"Peripheral Neuropathy and Low Dose Cisplatin","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W1963534497","doi":"https://doi.org/10.1097/00000421-198812000-00014","mag":"1963534497","pmid":"https://pubmed.ncbi.nlm.nih.gov/2847525"},"language":"en","primary_location":{"id":"doi:10.1097/00000421-198812000-00014","doi":"https://doi.org/10.1097/00000421-198812000-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000421-198812000-00014","pdf_url":null,"source":{"id":"https://openalex.org/S130927242","display_name":"American Journal of Clinical Oncology","issn_l":"0277-3732","issn":["0277-3732","1537-453X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109071976","display_name":"Andrew Greenspan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Greenspan","raw_affiliation_strings":["Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C. 20007","From the Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C. 20007","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"From the Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061100035","display_name":"Joseph Treat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Treat","raw_affiliation_strings":["the Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C","From the Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C","institution_ids":["https://openalex.org/I2799903593"]},{"raw_affiliation_string":"From the Division of Medical Oncology, Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2816,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59628329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"6","first_page":"660","last_page":"662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sensory-neuropathy","display_name":"sensory neuropathy","score":0.796999990940094},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/low-dose-chemotherapy","display_name":"low-dose chemotherapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cumulative-dose","display_name":"cumulative dose","score":0.6010000109672546},{"id":"https://openalex.org/keywords/metastatic-carcinoma","display_name":"metastatic carcinoma","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9754613041877747},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.8850014209747314},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8056463599205017},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7695451974868774},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6104686260223389},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5190404057502747},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.512796938419342},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.49875330924987793},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4936924874782562},{"id":"https://openalex.org/C2908603061","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Sensory neuropathy","level":2,"score":0.4534164071083069},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4332008361816406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3197535276412964},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000421-198812000-00014","doi":"https://doi.org/10.1097/00000421-198812000-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000421-198812000-00014","pdf_url":null,"source":{"id":"https://openalex.org/S130927242","display_name":"American Journal of Clinical Oncology","issn_l":"0277-3732","issn":["0277-3732","1537-453X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:2847525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2847525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051661023","https://openalex.org/W2163965772","https://openalex.org/W2085967834","https://openalex.org/W2088435772","https://openalex.org/W2167817128","https://openalex.org/W1986171910","https://openalex.org/W2123512791","https://openalex.org/W1975659607","https://openalex.org/W1971192992","https://openalex.org/W2084092457"],"abstract_inverted_index":{"Five":[0],"of":[1,21,31,58,66,73],"55":[2],"patients":[3],"with":[4,15],"metastatic":[5],"carcinomas":[6,10],"or":[7],"unresectable":[8],"primary":[9],"developed":[11,47],"a":[12,37],"peripheral":[13],"neuropathy":[14,26,46],"\"low":[16],"dose\"":[17],"cisplatin":[18],"therapy,":[19],"consisting":[20,30],"20":[22],"mg/m2":[23],"weekly.":[24],"The":[25,41,54],"was":[27],"primarily":[28],"sensory,":[29],"painful":[32],"parasthesias":[33],"and":[34,56],"numbness":[35],"in":[36],"\"stocking":[38],"glove\"":[39],"distribution.":[40],"cumulative":[42],"dose":[43,71],"at":[44],"which":[45],"varied":[48],"from":[49],"100":[50],"to":[51],"640":[52],"mg/m2.":[53],"symptoms":[55],"signs":[57],"neurologic":[59,77],"dysfunction":[60],"were":[61],"minimally":[62],"reversible":[63],"despite":[64],"discontinuation":[65],"the":[67],"drug.":[68],"Despite":[69],"lower":[70],"delivery":[72],"cisplatin,":[74],"significant":[75],"debilitating":[76],"toxicity":[78],"may":[79],"occur.":[80]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}