{"id":"https://openalex.org/W1963533732","doi":"https://doi.org/10.1074/jbc.m405979200","title":"Differential Modulation of Human Melanoma Cell Metalloproteinase Expression by \u03b12\u03b21 Integrin and CD44 Triple-helical Ligands Derived from Type IV Collagen","display_name":"Differential Modulation of Human Melanoma Cell Metalloproteinase Expression by \u03b12\u03b21 Integrin and CD44 Triple-helical Ligands Derived from Type IV Collagen","publication_year":2004,"publication_date":"2004-08-04","ids":{"openalex":"https://openalex.org/W1963533732","doi":"https://doi.org/10.1074/jbc.m405979200","mag":"1963533732","pmid":"https://pubmed.ncbi.nlm.nih.gov/15292257"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m405979200","doi":"https://doi.org/10.1074/jbc.m405979200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m405979200","pdf_url":"http://www.jbc.org/article/S0021925820680164/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820680164/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022103833","display_name":"Diane M. Baronas-Lowell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Baronas-Lowell","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton 33431-0991, USA","Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431\u20100991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton 33431-0991, USA","institution_ids":["https://openalex.org/I63772739"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431\u20100991","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054779535","display_name":"Janelle L. Lauer\u2010Fields","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janelle L. Lauer-Fields","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032871452","display_name":"Jeffrey Allen Borgia","orcid":"https://orcid.org/0000-0002-1520-7966","observed_orcids":["https://orcid.org/0000-0002-1520-7966"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Borgia","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018632927","display_name":"Gian Franco Sferrazza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gian Franco Sferrazza","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012694038","display_name":"Mohammad Al-Ghoul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Al-Ghoul","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017741352","display_name":"Dmitriy Minond","orcid":"https://orcid.org/0000-0003-2473-5944","observed_orcids":["https://orcid.org/0000-0003-2473-5944"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitriy Minond","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991","institution_ids":["https://openalex.org/I63772739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068707393","display_name":"Gregg B. Fields","orcid":"https://orcid.org/0000-0001-7126-1601","observed_orcids":["https://orcid.org/0000-0001-7126-1601"]},"institutions":[{"id":"https://openalex.org/I63772739","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387","country_code":"US","type":"education","lineage":["https://openalex.org/I63772739"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregg B. Fields","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991","institution_ids":["https://openalex.org/I63772739"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068707393"],"corresponding_institution_ids":["https://openalex.org/I63772739"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6635,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.81740209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"279","issue":"42","first_page":"43503","last_page":"43513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0722000002861023,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8999999761581421},{"id":"https://openalex.org/keywords/integrin-alpha2beta1","display_name":"alpha2beta1 integrin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chondroitin-sulfate-proteoglycans","display_name":"chondroitin sulfate proteoglycans","score":0.9520000219345093},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.9580000042915344},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.9610000252723694},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mmp-8","display_name":"MMP-8","score":0.828000009059906},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.996999979019165},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.9990000128746033},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6163665652275085},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.5914709568023682},{"id":"https://openalex.org/C2775895372","wikidata":"https://www.wikidata.org/wiki/Q5104536","display_name":"Chondroitin sulfate proteoglycan","level":4,"score":0.5913141965866089},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5870519280433655},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.5153176784515381},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44316548109054565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.442755788564682},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.43988198041915894},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.4110053777694702},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4084007143974304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3735278844833374},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.356507271528244},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3530077338218689},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33219659328460693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25755298137664795}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024141","descriptor_name":"Collagen Type IV","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024141","descriptor_name":"Collagen Type IV","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m405979200","doi":"https://doi.org/10.1074/jbc.m405979200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m405979200","pdf_url":"http://www.jbc.org/article/S0021925820680164/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15292257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15292257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m405979200","doi":"https://doi.org/10.1074/jbc.m405979200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m405979200","pdf_url":"http://www.jbc.org/article/S0021925820680164/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1909711857","display_name":null,"funder_award_id":"CA77402","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G460905305","display_name":null,"funder_award_id":"CA 98799","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6087503714","display_name":"Mechanism and Inhibition of Collagenolytic Activity","funder_award_id":"R01CA098799","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6553059775","display_name":"COLLAGEN STRUCTURAL MODULATION OF TUMOR BEHAVIORS","funder_award_id":"R01CA077402","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310801","display_name":"Florida Atlantic University","ror":"https://ror.org/05p8w6387"},{"id":"https://openalex.org/F4320317380","display_name":"Universidad del Atl\u00e1ntico","ror":"https://ror.org/05mm1w714"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963533732.pdf","grobid_xml":"https://content.openalex.org/works/W1963533732.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W11813027","https://openalex.org/W134683353","https://openalex.org/W595095674","https://openalex.org/W1482879694","https://openalex.org/W1492817730","https://openalex.org/W1494791538","https://openalex.org/W1498888463","https://openalex.org/W1554199252","https://openalex.org/W1561226826","https://openalex.org/W1576773659","https://openalex.org/W1587801474","https://openalex.org/W1599237496","https://openalex.org/W1924064381","https://openalex.org/W1964433907","https://openalex.org/W1965049968","https://openalex.org/W1965073779","https://openalex.org/W1965813817","https://openalex.org/W1969834700","https://openalex.org/W1970294293","https://openalex.org/W1971915817","https://openalex.org/W1976772770","https://openalex.org/W1978515475","https://openalex.org/W1981492773","https://openalex.org/W1982768448","https://openalex.org/W1983767497","https://openalex.org/W1983769138","https://openalex.org/W1983921365","https://openalex.org/W1986356056","https://openalex.org/W1987044254","https://openalex.org/W1987399488","https://openalex.org/W1987514824","https://openalex.org/W1988717603","https://openalex.org/W1989247542","https://openalex.org/W1990593113","https://openalex.org/W1991396579","https://openalex.org/W2003111769","https://openalex.org/W2006551247","https://openalex.org/W2006874648","https://openalex.org/W2008545225","https://openalex.org/W2012701739","https://openalex.org/W2014407412","https://openalex.org/W2021562312","https://openalex.org/W2021598069","https://openalex.org/W2025035446","https://openalex.org/W2035536358","https://openalex.org/W2038310113","https://openalex.org/W2038660465","https://openalex.org/W2044828823","https://openalex.org/W2048741686","https://openalex.org/W2050314447","https://openalex.org/W2050359791","https://openalex.org/W2052821405","https://openalex.org/W2052973016","https://openalex.org/W2053768042","https://openalex.org/W2055628427","https://openalex.org/W2056208534","https://openalex.org/W2056802402","https://openalex.org/W2059225346","https://openalex.org/W2063330553","https://openalex.org/W2065442216","https://openalex.org/W2065621361","https://openalex.org/W2067617639","https://openalex.org/W2069649792","https://openalex.org/W2072674959","https://openalex.org/W2078689066","https://openalex.org/W2080135127","https://openalex.org/W2084664594","https://openalex.org/W2084867085","https://openalex.org/W2087774979","https://openalex.org/W2088400996","https://openalex.org/W2094112385","https://openalex.org/W2095309845","https://openalex.org/W2096372265","https://openalex.org/W2103047157","https://openalex.org/W2106333878","https://openalex.org/W2106929134","https://openalex.org/W2110067017","https://openalex.org/W2111618967","https://openalex.org/W2115044953","https://openalex.org/W2116549174","https://openalex.org/W2119372661","https://openalex.org/W2125932935","https://openalex.org/W2134898309","https://openalex.org/W2137618168","https://openalex.org/W2139082708","https://openalex.org/W2146785334","https://openalex.org/W2150550500","https://openalex.org/W2156085478","https://openalex.org/W2166699632","https://openalex.org/W2168918180","https://openalex.org/W2169910516","https://openalex.org/W2337420828","https://openalex.org/W2406825328","https://openalex.org/W2415002006","https://openalex.org/W2803499602","https://openalex.org/W4236631361"],"related_works":["https://openalex.org/W1990593113","https://openalex.org/W2052821405","https://openalex.org/W2087774979","https://openalex.org/W1991396579","https://openalex.org/W2084797437","https://openalex.org/W2117596244","https://openalex.org/W1568679764","https://openalex.org/W2345652614","https://openalex.org/W6902869436","https://openalex.org/W2077504823"],"abstract_inverted_index":{"Tumor":[0],"cell":[1,61,83,147],"binding":[2,79,173],"to":[3,12,43,174],"components":[4],"of":[5,23,36,73,105,127,132,134,141,153,164,177,197],"the":[6,21,32,37,52,94,117,121,155,183,195],"basement":[7,38,178],"membrane":[8,39,179],"is":[9,31,41],"well":[10,59],"known":[11,42],"trigger":[13],"intracellular":[14],"signaling":[15],"pathways.":[16],"Signaling":[17],"ultimately":[18],"results":[19,161],"in":[20,199],"modulation":[22,133],"gene":[24],"expression,":[25],"facilitating":[26],"metastasis.":[27],"Type":[28],"IV":[29],"collagen":[30],"major":[33],"structural":[34],"component":[35],"and":[40,55,76,96,102,112,129,138],"be":[44],"a":[45,190],"polyvalent":[46],"ligand,":[47],"possessing":[48],"sequences":[49],"bound":[50],"by":[51],"alpha1beta1,":[53],"alpha2beta1,":[54],"alpha3beta1":[56],"integrins,":[57],"as":[58,60,66],"surface":[62],"proteoglycan":[63,69],"receptors,":[64],"such":[65],"CD44/chondroitin":[67],"sulfate":[68],"(CSPG).":[70],"The":[71],"role":[72],"alpha2beta1":[74,156],"integrin":[75,157],"CD44/CSPG":[77],"receptor":[78],"on":[80,151,182],"human":[81],"melanoma":[82,146],"activation":[84,166],"has":[85],"been":[86],"evaluated":[87],"herein":[88],"using":[89],"triple-helical":[90,186],"peptide":[91,187],"ligands":[92,188],"incorporating":[93],"alpha1(IV)382-393":[95],"alpha1(IV)1263-1277":[97],"sequences,":[98],"respectively.":[99],"Gene":[100],"expression":[101],"protein":[103],"production":[104],"matrix":[106],"metalloproteinases-1":[107],"(MMP-1),":[108],"-2,":[109,136],"-3,":[110],"-13,":[111,137],"-14":[113],"were":[114],"modulated":[115],"with":[116],"alpha2beta1-specific":[118],"sequence,":[119],"whereas":[120],"CD44-specific":[122],"sequence":[123],"yielded":[124],"significant":[125],"stimulation":[126],"MMP-8":[128],"lower":[130],"levels":[131],"MMP-1,":[135],"-14.":[139],"Analysis":[140],"enzyme":[142],"activity":[143],"confirmed":[144],"different":[145],"proteolytic":[148],"potentials":[149],"based":[150],"engagement":[152],"either":[154],"or":[158],"CD44/CSPG.":[159],"These":[160],"are":[162],"indicative":[163],"specific":[165],"events":[167],"that":[168],"tumor":[169],"cells":[170],"undergo":[171],"upon":[172],"select":[175],"regions":[176],"collagen.":[180],"Based":[181],"present":[184],"study,":[185],"provide":[189],"general":[191],"approach":[192],"for":[193],"monitoring":[194],"regulation":[196],"proteolysis":[198],"cellular":[200],"systems.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}